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A method for preparing Liandan anti-inflammatory tablets

A technology of lotus gallbladder and andrographis paniculata, applied in the directions of medical preparations containing active ingredients, anti-inflammatory agents, digestive system, etc., can solve the problems affecting the application of lotus gallbladder anti-inflammatory tablets, low content of active ingredients, inconvenient to take, etc. Large-scale industrial production, no harmful solvent residues, significant antibacterial and anti-inflammatory effects

Inactive Publication Date: 2018-12-14
李治尧
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation method in the prior art has a rough and backward process, many impurities, and low content of active ingredients, which leads to excessive dosage for patients and is inconvenient to take, which seriously affects the clinical application of Liandan Xiaoyan Tablets

Method used

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  • A method for preparing Liandan anti-inflammatory tablets
  • A method for preparing Liandan anti-inflammatory tablets
  • A method for preparing Liandan anti-inflammatory tablets

Examples

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preparation example Construction

[0025] A kind of preparation method of Liandan anti-inflammatory tablet provided by the invention comprises the following steps:

[0026] (1) Andrographis paniculata, bitter wood are pulverized into lotus gallbladder powder raw material;

[0027] (2) the gallbladder powder raw material of step (1) gained is packed in the extraction kettle, under the condition that is lower than the critical pressure of extractant and critical temperature all the time, extractant is compressed into liquid state, and extractant flows through extraction kettle, Under the condition of extraction temperature of 50-90°C and extraction pressure of 0.5-1.8 MPa, continuous extraction for 1-5 hours, the obtained extracted substance then flows into the analysis tank for analysis, and the extract is obtained by concentration and drying;

[0028] (3) extracting the extract obtained in step (2) with a solvent, and obtaining the extract after concentration and drying;

[0029] (4) After the extract obtained...

Embodiment 1

[0055] A preparation method for the extract of Liandan Xiaoyan Tablets provided in this embodiment comprises the following steps:

[0056] (1) raw material processing: according to the mass ratio of 0.5~2:1, the dried Andrographis paniculata and the dried bitter wood are crushed into 200-mesh lotus bile powder raw materials;

[0057] (2) continuous phase change extraction: measure the mixed solution of 2~5L ethanol and water (the volumetric concentration of ethanol is 85%), as extraction agent, the lotus gallbladder powder raw material of 1Kg step (1) gained is packed in the extraction kettle , under the condition of always lower than the critical pressure and critical temperature of the extractant, compress the extractant into a liquid state, the extractant flows through the extraction kettle, and extract continuously for 2 hours at the extraction temperature of 80°C and the extraction pressure of 1.2MPa, the obtained The extracted substance then flows into the analysis kettl...

Embodiment 2

[0059] In order to further illustrate the beneficial effects of the present invention, the steps of Example 1 are repeated, and the extraction pressure in the step (2) of Example 1 is replaced with 0.5MPa, 1.0MPa, 1.5MPa, 1.8MPa, and the obtained extracts are marked respectively Product 2, Product 3, Product 4, Product 5.

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Abstract

A method for preparing Liandan anti-inflammatory tablets is disclosed. The method includes (1) raw material treatment, (2) continuous phase transition extraction, (3) extraction with a solvent, and (4) granulation, tabletting, stamping and coating. A continuous phase transition extraction technique is adopted to extract effective components of common andrographis herb and ramulus et folium picrasmae. The method is simple in process and high in operability, can effectively reduce the production cost, shorten the extraction separation time and reduce energy consumption in the process. The process is safe, environmentally friendly, free of pollution, free of residue of harmful solvents, and capable of large-scale industrial production. An extract obtained by continuous phase transition extraction and an extract obtained by further purification have significant antibacterial and anti-inflammatory effects. The prepared tablets are safe and reliable, have a total effective rate of 94% when being used for treating acute infectious diseases, and have curative effects higher than those of Liandan anti-inflammatory tablets commercially available.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a preparation method of Liandan Xiaoyan Tablets. Background technique [0002] Lian Dan Xiao Yan Tablets, heat-clearing and detoxifying. For abdominal pain and diarrhea caused by heat toxin, tenesmus, mucus pus and blood in stool and bacillary dysentery. The preparation method in the prior art has rough and backward process, many impurities, and low active ingredient content, which leads to excessive dosage for patients and is inconvenient to take, which seriously affects the clinical application of Liandan Xiaoyan Tablets. Contents of the invention [0003] The purpose of the present invention is to provide a preparation method of Liandan Xiaoyan Tablets to solve the above technical problems. [0004] In order to achieve the above object, the technical solution of the present invention is: [0005] A kind of preparation method of Liandan anti-inflammat...

Claims

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Application Information

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IPC IPC(8): A61K9/28A61K36/19A61K36/185A61P1/12A61P31/04A61P29/00
CPCA61K9/2095A61K9/2873A61K36/185A61K36/19A61K2236/37A61P1/12A61P29/00A61P31/04A61K2300/00
Inventor 李治尧
Owner 李治尧