Herba clerodendranthi extract slow-release tablets and production method thereof

A production method and technology for sustained-release tablets, which can be applied to pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc. Increase the number of patients and other problems to achieve the effect of high effectiveness, less gastrointestinal irritation, and improved curative effect

Inactive Publication Date: 2018-12-21
HAINAN SENQI PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, although there are many medicines for the treatment of throat diseases at present, they only play an emergency treatment role, and lack long-acting Chinese medicine slow-controlled dosage forms. , compared with the corresponding common preparation, the dosing frequency is reduced by half or the dosing frequency is reduced compared with the common preparation, and the patient's compliance can be significantly increased, and the controlled-release preparation is based on the sustained-release preparation On the other hand, the blood drug concentration is more stable and can significantly increase the compliance of patients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The Sustained-release Tablets of Echinacea Extract of this Example include Echinacea Extract, Hydroxypropylmethylcellulose, Polyvinylpyrrolidone, Microcrystalline Cellulose, Magnesium Stearate and Lubricants.

[0025] The chemical constituents of the gallwood are mainly concentrated in the stem of the gallwood. The stem of the gallwood mainly contains alkaloids and alkaloid glycosides. The content of the extract of the gallwood is equal to 200 times that of the gallwood, that is, the extract of the gallwood mentioned in the present invention 1 part of the product is extracted from 200 parts of bile wood.

[0026] Hydroxypropyl methylcellulose is a rate-controlling polymer material for sustained-release preparations. As a stabilizer, it is safe and non-toxic, and can also be used as a food additive.

[0027] The polyvinylpyrrolidone involved in the present invention is pharmaceutical-grade polyvinylpyrrolidone, which is used as a binder for tablets and granules.

[0028...

Embodiment 2

[0030] In the sustained-release tablet of the extract of bile wood provided in the present embodiment, each component is respectively in proportion by weight: 120-140 parts of the bile wood extract, 60-100 parts of hydroxypropyl methylcellulose, and 8-12 parts of polyvinylpyrrolidone. parts, 60-80 parts of microcrystalline cellulose, 6-8 parts of magnesium stearate, 0.1-1 part of lubricant, and the preferred components are: 130 parts of eucalyptus extract, 130 parts of hypromellose 80 parts of base cellulose, 10 parts of polyvinylpyrrolidone, 70 parts of microcrystalline cellulose, 7 parts of magnesium stearate, and 0.5 parts of lubricant. Wherein, the content of the extract of the gallwood is equivalent to 200 times of the content of the wood of the gallwood, that is, the content of the active ingredient in one part of the extract of the gallwood is equal to the active ingredient extracted from 200 parts of the tree of the gallwood.

Embodiment 3

[0032] The present invention provides a kind of preparation method of danmu extract sustained-release tablet, and concrete operation steps are as follows:

[0033] S1: Weighing and decocting, weigh the extract of the eucalyptus, add purified water for decoction twice, add purified water 4-6 times the quality of the eucalyptus extract for the first time, decoct for 1-2h, add it for the second time Purified water with 3-5 times the quality of the extract of the eucalyptus, decocted for 1-2h; The content of gallwood extract in the liquid obtained by decocting for the first time is higher. According to the test results, this method can increase the content of gallwood extract by 3% to 5%.

[0034] S2: Concentrate by filtration and spray-dry, concentrate the decoction after filtering, use water as the reference density, concentrate to a relative density of 1.05-1.25, and then spray-dry to obtain extract powder;

[0035] S3: Mix and granulate, weigh hydroxypropyl methylcellulose, p...

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Abstract

The invention relates to herba clerodendranthi extract slow-release tablets. The herba clerodendranthi extract slow-release tablets are prepared from herba clerodendranthi extract, hydroxypropyl methylcellulose, polyvinylpyrrolidone, microcrystalline cellulose, magnesium stearate and a lubricant. At present, herba-clerodendranthi-containing drugs for treating throat diseases are more, but only have a treatment effect and a long-effect traditional Chinese medicine slow-release preparation is lacked; compared with corresponding common preparations, the herba clerodendranthi extract slow-releasetablets provided by the invention have the advantages that the dosing frequency is reduced by one half when being compared with that of the common preparations or is reduced when being compared with that of the common preparations; the preparation capable of remarkably increasing the compliance of patients can be used for remarkably increasing the compliance of the patients.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine preparations, in particular to a slow-release tablet of Danmu extract and a preparation method thereof. Background technique [0002] Gallwood, also known as mountain bear bile, bear bile tree, ebony, and medicinal ebony, is an arbor plant of the genus Ebony in the Rubiaceae family. It grows in miscellaneous forests near the top of mountains or in shaded and humid areas on the mountainside. It is distributed in Guangdong (western and Southwest), Guangxi and Hainan, etc. The stems of gallwood mainly contain alkaloids and alkaloid glycosides. As medicinal materials, the branches and bark of gallwood are collected and split into irregular pieces and blocks. The color is light yellow or brownish yellow, and the outer skin is brownish yellow. Rough, relatively loose, easy to detach, cross-section skin part brown, xylem yellow or brownish yellow, hard texture, slightly bitter smell, bright y...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K36/74A61K47/38A61K47/32A61P11/04A61P11/00
CPCA61K9/2027A61K9/2054A61K36/74A61K2236/331A61K2236/39A61P11/00A61P11/04
Inventor 曾纪锴张鹏韩法河廖锦红肖跃国
Owner HAINAN SENQI PHARMA CO LTD
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