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Composition for regulating body immunologic balance of cancerous persons and preparation method of composition

A technology for immune and balance regulation of the body, applied in the directions of drug combinations, medical preparations containing active ingredients, applications, etc., can solve the problems of immune system imbalance, inability to effectively identify and kill tumor cells, low, etc., and achieve the preparation method. Simple and convenient effects

Inactive Publication Date: 2018-12-25
单风平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0018] The current problem is: Doctors and cancer patients know little about complete immunotherapy and immune recovery
However, for patients with cancer cells, the immune system is generally dysregulated or low, and cannot effectively identify and kill tumor cells; on the other hand, the massive proliferation of tumor cells will further inhibit the immune function of patients. To escape the recognition and killing of immune cells, the immunotherapy of tumors is to improve the immunogenicity of tumors with the help of molecular biology technology and cell engineering technology, to supplement the body with a sufficient number of normally functioning immune cells and related molecules, to stimulate and enhance tumor immunity. The body's anti-tumor immune response, improve the sensitivity of the tumor to the body's anti-tumor immune effect, induce tumor-specific and non-specific effector cells and molecules in vivo and in vitro, and achieve the ultimate goal of tumor removal

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Chris Perce, male, 66, 80kg, American, was diagnosed with rectal cancer two years ago. After surgery, liver metastases and severe imbalance of immune indicators. The immune parameters returned to normal after being adjusted for three months with the comprehensive adjustment method of immune balance.

[0042] Pre-regulatory immune system indicators

[0043] CD3+CD4+CD8-: 0.28 (34.0%-70.0%);

[0044] CD3+CD4-CD8+: 0.70 (25.0%-54.0%);

[0045] CD4+ / CD8+: 0.68 (1.5-2.5)

[0046] NKCD3- / CD16+56+: 24% (5-15%)

[0047] Adjusted immune system indicators

[0048] CD3+CD4+CD8-: 0.38 (34.0%~70.0%);

[0049] CD3+CD4-CD8+: 0.51 (25.0%-54.0%);

[0050] CD4+ / CD8+: 1.3 (0.7~2.5)

[0051] NKCD3- / CD16+56+: 12%.

[0052] The immunomodulatory drug of the immunomodulatory component includes BCG nucleic acid polysaccharide, thymosin, immune peptide, transfer factor, pidotimod, interferon and interleukin, with the same mass, the total mass is 0.01*0.6*80=0.48 micrograms; Foods includ...

Embodiment 2

[0059] Ms. Zhang, 53 years old, 50kg, cervical cancer surgery three years ago, ascites metastasis. Lymph nodes throughout the body infected with cancer cells. Immune indicators are seriously out of balance. After two to three months of adjustment using the immune balance comprehensive adjustment method, the immune parameters returned to normal.

[0060] Pre-regulatory immune system indicators

[0061] CD3+CD4+CD8-: 0.24 (34.0%-70.0%);

[0062] CD3+CD4-CD8+: 0.77 (25.0%-54.0%);

[0063] CD4+ / CD8+: 0.51 (0.7-2.5)

[0064] NKCD3- / CD16+56+: 21% (5-15%)

[0065] Adjusted immune system indicators

[0066] CD3+CD4+CD8-: 0.40 (34.0%~70.0%);

[0067] CD3+CD4-CD8+: 0.51 (25.0%-54.0%);

[0068] CD4+ / CD8+: 1.24 (0.7-2.5)

[0069] NKCD3- / CD16+56+: 13% (5-15%).

[0070] The immunomodulatory components of the immunomodulatory drug include BCG nucleic acid polysaccharide, thymosin, immune peptide, transfer factor, pidotimod, interferon and interleukin, with the same mass and a total...

Embodiment 3

[0077] Mr. Xiao, 66 years old, 120kg, suffered from gastrointestinal cancer in 2016. Digestive tract blockage. Clinical has been abandoned. After two months of adjustment using the comprehensive adjustment method of immune balance, the immune parameters returned to normal.

[0078] Pre-regulatory immune system indicators

[0079] CD3+CD4+CD8-: 0.31 (34.0%-70.0%);

[0080] CD3+CD4-CD8+: 0.65 (25.0%-54.0%);

[0081] CD4+ / CD8+: 0.66 (1.5-2.5)

[0082] NKCD3- / CD16+56+: 31% (5-15%)

[0083] Adjusted immune system indicators

[0084] CD3+CD4+CD8-: 0.45 (34.0%~70.0%);

[0085] CD3+CD4-CD8+: 0.52 (25.0%-54.0%);

[0086] CD4+ / CD8+: 1.56 (0.7-2.5)

[0087] NKCD3- / CD16+56+: 11%. (5-15%).

[0088] The immunomodulatory drugs of the immunomodulatory component include BCG nucleic acid polysaccharide, thymosin, immune peptide, transfer factor, pidotimod, interferon and interleukin, with the same mass and a total mass of 0.06 g; the immunomodulatory food includes astragalus polysacc...

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PUM

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Abstract

The invention relates to a composition for regulating body immunologic balance of cancerous persons. The composition is characterized by comprising an immunologic regulation component, an inflammationregulation component, a micro-environment regulation component and an intestinal regulation component; the preparation method includes sequentially covering the intestinal regulation component, the immunologic regulation component (which refers to BCG-PSN preserved in an injector independently), the micro-environment regulation component and the inflammation regulation component (which refers tocamptothecin and anti-tumor RNA respectively preserved in different injectors) sequentially from inside to outside with capsules to separate the four components mutually; the application is to take the composition on an empty stomach. As BCG-PSN, camptothecin and anti-tumor RNA are administrated by injecting, regulation results can be balanced integrally and immunity index of lymphocyte subpopulation can return to normal.

Description

technical field [0001] The invention is in the field of medicines for the human immune system and tumor microenvironment, and in particular relates to a composition and a preparation method for adjusting the immune balance of cancer patients. Background technique [0002] The immune system has the functions of immune surveillance, defense and regulation. This system consists of immune organs (bone marrow, spleen, lymph nodes, tonsils, Peyer's lymph nodes, appendix, thymus, etc.), immune cells (lymphocytes, mononuclear phagocytes, neutrophils, basophils, eosinophils, Mast cells, platelets (because there are IgG in platelets, etc.), and immune active substances (antibodies, lysozyme, complement, immunoglobulin, interferon, interleukin, tumor necrosis factor and other cytokines). The immune system is divided into innate immunity (also known as non-specific immunity) and adaptive immunity (also known as specific immunity), of which adaptive immunity is further divided into humo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61K31/427A61K38/21A61K38/20A61K38/08A61K31/7088A61K31/167A61K31/616A61K31/192A61K31/375A61K31/355A61K31/4745A61P35/00A61P37/02A23L33/10A23L33/18A23L33/125
CPCA23L33/10A23L33/125A23L33/18A23V2002/00A61K31/167A61K31/192A61K31/355A61K31/375A61K31/427A61K31/4745A61K31/616A61K31/7088A61K38/08A61K38/20A61K38/21A61K45/06A61P35/00A61P37/02A61K2300/00A23V2200/324A23V2250/55
Inventor 单风平
Owner 单风平
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