Mesoporous silica microsphere and rhizoma bletillae polysaccharide composite hemostatic material and preparation method thereof

A technology of mesoporous silica and Bletilla striata polysaccharide, applied in pharmaceutical formulations, surgical adhesives, applications, etc., can solve the problem of shortening the thromboplastin time and prothrombin time, the effect of red blood cell and platelet aggregation is not obvious, the pain of the wounded, etc. problems, to achieve good hemostasis, promote platelet aggregation, and high water absorption.

Inactive Publication Date: 2018-12-25
宁夏悦丰生态农业科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, zeolite hemostatic agent has a big disadvantage. While absorbing water, it will release a lot of heat, which will cause the temperature of the wound site to rise sharply, causing the wounded to feel pain and cause burns.
[0004] Wang Liqun et al proposed that the composite hemostatic adjuvant prepared by mesoporous silica microspheres and starch has strong water abs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Weigh the pore form as mesopore, and the specific surface area is concentrated at 200m 2 Add 2 grams of silicon dioxide microspheres with an average particle size of 1-4 μm or more per gram and 2 grams of Bletilla striata polysaccharide into 100 mL of deionized water, mix evenly with a vortex mixer for 5 minutes, and freeze-dry to obtain 4 grams of composite hemostatic material.

[0017] After testing, the APTT of the composite hemostatic material prepared above was 15.21 s, and the PT was 64.7±2.32 s, and the above time unit was second.

Embodiment 2—5

[0019] On the basis of Example 1, the proportioning relationship between silica microspheres and Bletilla striata polysaccharide was changed, and other conditions remained unchanged.

[0020] Example

The weight ratio of mesoporous silica microspheres to Bletilla striata polysaccharide

APTT

PT

Example 2

1:2

18.46s

84.8±2.12 s

Example 3

1:3

20.69s

86.7±2.49s

Example 4

1:4

22.12s

88.1±2.10s

[0021] The aforementioned APTT is the partial thromboplastin time, and the smaller the index, the better the coagulation effect of the material.

[0022] The above PT is the prothrombin time, and the smaller the index, the better the hemostatic effect of the material.

[0023] On the basis of the remaining conditions of the above examples remaining unchanged, when using non-mesoporous silica microspheres for experiments, APTT is 32.31s and PT is 168.5±2.15s. It can be seen that the use of mesoporous silica microspheres...

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Abstract

The invention relates to a hemostatic material and preparation thereof, in particular to a mesoporous silica microsphere and rhizoma bletillae polysaccharide composite hemostatic material and a preparation method thereof. The composite hemostatic material is characterized by being prepared from mesoporous silica microspheres and rhizoma bletillae polysaccharides according to a weight ratio of 1:1-4. The technical scheme includes that by taking the advantage of large specific surface area and porous structure of the mesoporous silica microspheres and taking advantages of astringency, hemostasisand platelet aggregation promotion of rhizoma bletillae polysaccharides, the rhizoma bletillae polysaccharides are positioned in the mesoporous silica microspheres, so that the mesoporous silica microspheres serve as carriers while making use of the characteristics of the rhizoma bletillae polysaccharides is realized. Therefore, the composite hemostatic powder has advantages of high water absorption rate, great hemostatic effects, convenience in use, freeness of wound surface and wound size limitations and the like, can be used for wound hemostasis and surgical nursing and is an excellent visceral wound hemostatic material.

Description

Technical field [0001] The invention relates to a hemostatic material and its preparation, in particular to a composite hemostatic material of mesoporous silicon dioxide microspheres and bletilla striata polysaccharide and its preparation method. Background technique [0002] In various emergencies, bleeding from human trauma is very common. Whether bleeding wounds can be quickly and effectively stopped bleeding in a short period of time is a current research hotspot. Traditional methods of hemostasis, such as pressurization, dressing packing, and tourniquet, all use pressure to stop bleeding, and tourniquet hemostasis can also cause remote tissue ischemia and metabolic abnormalities, leading to serious complications. In recent years, medical hemostatic materials have attracted great attention from the medical and industrial circles, and many large pharmaceutical companies are committed to developing new hemostatic materials. [0003] The reason why the inorganic oxide zeol...

Claims

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Application Information

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IPC IPC(8): A61L24/08A61L24/00A61L24/02
CPCA61L24/0015A61L24/0036A61L24/02A61L24/08A61L2300/232A61L2300/418A61L2400/04C08L5/00
Inventor 杨玉明段斌胡奇林
Owner 宁夏悦丰生态农业科技股份有限公司
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