Mesoporous silica microsphere and rhizoma bletillae polysaccharide composite hemostatic material and preparation method thereof

Abstract

The invention relates to a hemostatic material and preparation thereof, in particular to a mesoporous silica microsphere and rhizoma bletillae polysaccharide composite hemostatic material and a preparation method thereof. The composite hemostatic material is characterized by being prepared from mesoporous silica microspheres and rhizoma bletillae polysaccharides according to a weight ratio of 1:1-4. The technical scheme includes that by taking the advantage of large specific surface area and porous structure of the mesoporous silica microspheres and taking advantages of astringency, hemostasisand platelet aggregation promotion of rhizoma bletillae polysaccharides, the rhizoma bletillae polysaccharides are positioned in the mesoporous silica microspheres, so that the mesoporous silica microspheres serve as carriers while making use of the characteristics of the rhizoma bletillae polysaccharides is realized. Therefore, the composite hemostatic powder has advantages of high water absorption rate, great hemostatic effects, convenience in use, freeness of wound surface and wound size limitations and the like, can be used for wound hemostasis and surgical nursing and is an excellent visceral wound hemostatic material.

Description

Technical field [0001] The invention relates to a hemostatic material and its preparation, in particular to a composite hemostatic material of mesoporous silicon dioxide microspheres and bletilla striata polysaccharide and its preparation method. Background technique [0002] In various emergencies, bleeding from human trauma is very common. Whether bleeding wounds can be quickly and effectively stopped bleeding in a short period of time is a current research hotspot. Traditional methods of hemostasis, such as pressurization, dressing packing, and tourniquet, all use pressure to stop bleeding, and tourniquet hemostasis can also cause remote tissue ischemia and metabolic abnormalities, leading to serious complications. In recent years, medical hemostatic materials have attracted great attention from the medical and industrial circles, and many large pharmaceutical companies are committed to developing new hemostatic materials. [0003] The reason why the inorganic oxide zeol...

AI Technical Summary

Problems solved by technology

However, zeolite hemostatic agent has a big disadvantage. While absorbing water, it will release a lot of heat, which will cause the temperature of the wound site to rise sharply, causing the wounded to feel pain and cause burns.

[0004] Wang Liqun et al proposed that the composite hemostatic adjuvant prepared by mesoporous silica microspheres and starch has strong water absorption performance and obvious in vitro coagulation performance, which can significantly shorten the partial thromboplastin time and prothrombin time, and can prevent Bleeding and shortening the bleeding time of the rabbit's back skin and liver wounds have obvious hemostatic effect, but it has no obvious effect on promoting the aggregation of red blood cells and platelets