Application of snp site of clip3 gene

Abstract

The present invention discloses a method for screening SNP sites related to aortic dissection disease based on whole exome sequencing technology. The SNP sites include the following SNP sites for susceptibility to aortic dissection: CLIP3:NM_001199570:exon1:c.32C >T:p.P11L. Further, the present invention provides the application of the SNP site in detection products for detecting aortic dissection disease. The present invention discovers a susceptibility SNP locus of aortic dissection and studies its application prospect in the early prediction of aortic dissection. The gene loci related to aortic dissection provided by the present invention may be early biomarkers of aortic dissection , which provides a new direction for further study of the genetic and molecular mechanism of aortic dissection and the exploration of drug targets for the early prevention and treatment of aortic dissection.

Description

technical field

[0001] The invention relates to the technical field of biomedical detection, in particular to the application of the SNP site of the CLIP3 gene related to aortic dissection disease. Background technique

[0002] Aortic dissection (AD) refers to a series of external factors (such as high blood pressure, trauma, etc.), based on the presence or absence of lesions in the aortic wall itself, a breach in the aortic intima occurs. Blood in the aortic intimal breach invades the middle layer of the aortic wall, and the aortic middle layer is continuously torn and separated longitudinally, resulting in a state of coexistence of true and false aortic lumens. Aortic dissection has sudden onset, rapid development, and severe prognosis. Despite the continuous improvement of various current treatment methods, the morbidity and mortality of AD are still high, and if proper and timely treatment is not carried out, the mortality rate of AD is extremely high. It has been repo...

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