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A green method for preparing calcium hydroxyphosphate nanorods

A technology of calcium hydroxyphosphate and nanorods, applied in the preparation of calcium hydroxyphosphate nanorods, in the field of preparation of calcium hydroxyphosphate nanorods, can solve the problems of low biocompatibility, too large crystal grains, complicated operation, etc., and achieve easy operation , large aspect ratio and short process

Active Publication Date: 2021-11-19
NANCHANG HANGKONG UNIVERSITY
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0005] The present invention aims at the disadvantages of low environmental protection, low biocompatibility, complicated operation, large crystal grains, high cost and the like in the existing method for preparing calcium hydroxyphosphate nanorods, and proposes a method that is environmentally friendly, easy to operate, short in process and stable in process. Green method for calcium hydroxyphosphate nanorods with high stability, thin diameter, large aspect ratio, high yield and low cost

Method used

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  • A green method for preparing calcium hydroxyphosphate nanorods

Examples

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Embodiment 1

[0012] In a 100 L hydrothermal reactor, add 3.27 kg of calcium sulfate dihydrate, 6.54 kg of sodium phosphate dodecahydrate and 73.5 kg of distilled water in sequence, mix well and heat. From room temperature to 170°C, keep the reaction for 6 h. After the reaction was completed, it was cooled to room temperature, the product was filtered, washed with distilled water three times, and dried at 105 °C for 1 h to obtain calcium hydroxyphosphate nanorods. The diameter of calcium hydroxyphosphate nanorods is 40 nm to 70 nm, the length is 160 nm to 240 nm, the aspect ratio is 2.3 to 6.0, and the yield is 98%.

Embodiment 2

[0014] In a 100 L hydrothermal reactor, add 3.27 kg of calcium sulfate dihydrate, 6.23 kg of sodium phosphate dodecahydrate and 70.0 kg of distilled water in sequence, mix well and heat. From room temperature to 180°C, keep the reaction for 5 h. After the reaction was completed, it was cooled to room temperature, the product was filtered, washed with distilled water three times, and dried at 105 °C for 1 h to obtain calcium hydroxyphosphate nanorods. The diameter of calcium hydroxyphosphate nanorods is 40 nm to 70 nm, the length is 160 nm to 240 nm, the aspect ratio is 2.3 to 6.0, and the yield is 97%.

Embodiment 3

[0016] In a 100 L hydrothermal reaction kettle, add 3.27 kg of calcium sulfate dihydrate, 6.85 kg of sodium phosphate dodecahydrate and 77.0 kg of distilled water in sequence, mix well and heat. From room temperature to 160°C, keep the reaction for 7 h. After the reaction was completed, it was cooled to room temperature, the product was filtered, washed with distilled water three times, and dried at 105 °C for 1 h to obtain calcium hydroxyphosphate nanorods. The calcium hydroxyphosphate nanorods have a diameter of 40 nm to 70 nm, a length of 160 nm to 240 nm, an aspect ratio of 2.3 to 6.0, and a yield of 99%.

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Abstract

The invention discloses a green method for preparing calcium hydroxyphosphate nanorods. Calcium sulfate dihydrate is used as a raw material, sodium phosphate dodecahydrate is used as a hydrothermal conversion agent, and distilled water is used as a reaction medium to prepare calcium hydroxyphosphate nanorods. In the hydrothermal reaction kettle, add calcium sulfate dihydrate, sodium phosphate dodecahydrate and distilled water in sequence, and mix well. From room temperature to the target control temperature, heat preservation reaction for 5 h to 7 h. Cool to room temperature, filter the product, wash with distilled water, and dry at 105°C to obtain calcium hydroxyphosphate nanorods. The diameter of calcium hydroxyphosphate nanorods is 40 nm to 70 nm, the length is 160 nm to 240 nm, and the aspect ratio is 2.3 to 6.0, the yield is 97% to 99%. The invention has the characteristics of environmental protection, simple and convenient operation, short process, high process stability, large aspect ratio, high yield and the like.

Description

technical field [0001] The invention relates to a green method for preparing calcium hydroxyphosphate nanorods, in particular to a method for preparing calcium hydroxyphosphate nanorods using calcium sulfate dihydrate as a raw material, sodium phosphate dodecahydrate as a hydrothermal conversion agent, and distilled water as a reaction medium method. The specific technical field of the invention is the preparation of calcium hydroxyphosphate nanorods. Background technique [0002] Calcium hydroxyphosphate is the main inorganic component of human bones and teeth. It has good biocompatibility, biodegradability and osteoconductivity, and has good application prospects in clinical medicine, drug carriers, fluorescent probes and other fields. The morphology of calcium hydroxyphosphate crystals in human bones is mostly nanorods of 50 nm × 25 nm, so the research on calcium hydroxyphosphate nanorods has far-reaching significance. [0003] Nowadays, in the existing methods for prep...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C01B25/32B82Y40/00
CPCB82Y40/00C01B25/325C01P2004/03C01P2004/16
Inventor 李艳容钟学明刘俊辰徐玉娜刘涛
Owner NANCHANG HANGKONG UNIVERSITY
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