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Pharmaceutical composition containing tribulus terrestris fruit total saponin and preparation method thereof

A technology of Tribulus terrestris and total saponins, which is applied in the field of pharmaceutical compositions containing Tribulus terrestris total saponins and its preparation, can solve the problems of no application of Tribulus terrestris total saponins, insufficient safe utilization of total saponins bioactivity, difficulty in using Tribulus terrestris saponins, etc. Achieve the effect of cost reduction, large packing loss and low yield

Inactive Publication Date: 2019-01-11
李梓嘉
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In summary, due to the current technology to obtain the monomer of Tribulus terrestris saponins, the biological activity and safe utilization of its total saponins are insufficient
[0006] The prior art does not apply total saponins of Tribulus terrestris to medicine, but the present invention provides an effective separation and purification method for obtaining total saponins of Tribulus terrestris (Saponin K of Tribulus terrestris, saponin of Tribulus terrestris D)

Method used

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  • Pharmaceutical composition containing tribulus terrestris fruit total saponin and preparation method thereof
  • Pharmaceutical composition containing tribulus terrestris fruit total saponin and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0030] Take 5000g of dried fruit thorns of Tribulus terrestris, add 6 times the weight concentration of 70% (W / W) ethanol to heat and reflux to extract 5 times after crushing, combine the extracts, concentrate under reduced pressure until there is no alcohol smell, and let stand at room temperature. Extract with ethyl acetate, and concentrate the aqueous phase under reduced pressure until there is no ethyl acetate; 1500ml of concentrated liquid is obtained, and after standing at room temperature; the obtained concentrated liquid is enriched on the AB-8 column, and then washed with 10 column volumes of water ; Wash with 10 column volumes of 40% ethanol; finally analyze with 90% ethanol. The analytical solution of 90% ethanol, after concentrating under reduced pressure to no alcohol, mixes the sample with 1 times of the mass of the concentrate, and the obtained silica gel mixed sample is subjected to normal phase silica gel column chromatography, with 10 to 20 times of the silica...

Embodiment 2

[0032]Take 5000g of dried fruit thorns of Tribulus terrestris, add 10 times the weight concentration of 70% (W / W) ethanol to heat and reflux to extract 5 times after crushing, combine the extracts, concentrate under reduced pressure until there is no alcohol smell, and let stand at room temperature. Extract with ethyl acetate, and concentrate the aqueous phase under reduced pressure until there is no ethyl acetate; get 2000ml of concentrated liquid, and let it stand at room temperature; enrich the obtained concentrated liquid on AB-8 column, wash it with 10 column volumes of water first ; Wash with 10 column volumes of 40% ethanol; finally analyze with 90% ethanol. The analytical solution of 90% ethanol, after concentrating under reduced pressure to no alcohol, mixes the sample with 1 times of the mass of the concentrate, and the obtained silica gel mixed sample is subjected to normal phase silica gel column chromatography, with 10 to 20 times of the silica gel as a filler, Pa...

Embodiment 3

[0034] Take 5000 g of dried fruit thorns of Tribulus terrestris, add 12 times the weight concentration of 70% (W / W) ethanol to heat and reflux to extract 5 times after crushing, combine the extracts, concentrate under reduced pressure until there is no alcohol smell, and let stand at room temperature. Extract with ethyl acetate, and concentrate the aqueous phase under reduced pressure until there is no ethyl acetate; get 2800ml of concentrated liquid, and let it stand at room temperature; enrich the obtained concentrated liquid on the AB-8 column, wash it with 10 column volumes of water first ; Wash with 10 column volumes of 40% ethanol; finally analyze with 90% ethanol. The analytical solution of 90% ethanol, after concentrating under reduced pressure to no alcohol, mixes the sample with 1 times of the mass of the concentrate, and the obtained silica gel mixed sample is subjected to normal phase silica gel column chromatography, with 10 to 20 times of the silica gel as a fille...

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Abstract

The invention belongs to the technical field of drug preparation, and discloses a pharmaceutical composition containing tribulus terrestris fruit total saponin and a preparation method thereof. The harmaceutical composition containing tribulus terrestris fruit total saponin takes tribulus terrestris fruit total saponin as basic active ingredient; the basic active ingredient of the tribulus terrestris fruit total saponin is formed by tribulus terrestris saponin D and tribulus terrestris saponin K; and the preparation method of the pharmaceutical composition containing tribulus terrestris fruittotal saponin is to mix tribulus terrestris fruit total saponin with one or multiple pharmaceutically acceptable carriers and excipients.

Description

technical field [0001] The invention belongs to the technical field of medicine preparation, and in particular relates to a medicine composition containing total saponins of Tribulus terrestris and a preparation method thereof. Background technique [0002] At present, ethanol extraction is commonly used in the industry, and the concentrated solution is sequentially extracted with petroleum squint, chloroform, ethyl acetate and n-butanol to obtain total saponins; (ion exchange chromatography) gel chromatography (gelchromatography), etc.; purification to obtain various saponin components. At the same time, studies have shown that Tribulus terrestris has good pharmacological activity on the cardiovascular and cerebrovascular systems, and the total saponins contained in it are proven active components on the cardiovascular and cerebrovascular systems. [0003] Tribulus terrestris L. belongs to the genus Tribulus terrestris in plant taxonomy. Tribulus terrestris fruit and stem...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J71/00A61K36/185
CPCA61K36/185C07J71/0005
Inventor 李彦群
Owner 李梓嘉
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