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Method for separating L-ribose

A separation method and ribose technology, applied in the field of sugar engineering, can solve problems such as low product yield and complex process, and achieve the effects of increasing separation efficiency and purity, solving low purity and simplifying production process methods.

Active Publication Date: 2019-01-18
FUTASTE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main process is isomerization reaction - decolorization filtration - anion and cation resin exchange - evaporation concentration - simulated moving bed chromatography separation and purification - concentration evaporation - crystallization and centrifugation to obtain L-ribose, the process is complex and the product yield is low

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] A method for separating L-ribose, the method steps are as follows:

[0018] Step 1) Isomerization reaction: Add 300g of L-arabinose, 0.5g of ammonium molybdate and 500g of pure water into the reactor, mix well, adjust the pH value between 3.0 and the temperature of 110°C, and react in the reactor for 2.5 hours. The conversion rate of isomerization reaction is 25%;

[0019] Step 2) One-time vacuum distillation: send the materials in the reactor to the distillation and concentration equipment, and use a vacuum pump to carry out one-time vacuum distillation. At this time, the main component of the distillate is water;

[0020] Step 3) Secondary vacuum distillation: adjust vacuum pump pressure -0.08Mpa; temperature 120°C, carry out secondary vacuum distillation until almost no distillate is distilled out. At this time, the main component of the distillate is L-ribose with a purity of 95% , the main residual component in the reactor is L-arabinose.

Embodiment 2

[0022] A method for separating L-ribose, the method steps are as follows:

[0023] Step 1) Isomerization reaction: Add 450g of L-arabinose, 1.5g of ammonium molybdate and 600g of pure water into the reactor, after mixing evenly, adjust the pH value between 4.0 and the temperature of 120°C, and react in the reactor for 2 hours. The conversion rate of isomerization reaction is 30%;

[0024] Step 2) One-time vacuum distillation: send the materials in the reactor to the distillation and concentration equipment, and use a vacuum pump to carry out one-time vacuum distillation. At this time, the main component of the distillate is water;

[0025] Step 3) Secondary vacuum distillation: adjust vacuum pump pressure -0.09Mpa; temperature 115°C, carry out secondary vacuum distillation until almost no distillate is distilled out. At this time, the main component of the distillate is L-ribose with a purity of 97% , the main residual component in the reactor is L-arabinose.

Embodiment 3

[0027] A method for separating L-ribose, the method steps are as follows:

[0028] Step 1) Isomerization reaction: Add 500g of L-arabinose, 2g of ammonium molybdate and 900g of pure water into the reactor, mix well, adjust the pH value between 5.0 and 100°C, react in the reactor for 4 hours, iso Constructive reaction conversion rate of 35%;

[0029] Step 2) One-time vacuum distillation: send the materials in the reactor to the distillation and concentration equipment, and use a vacuum pump to carry out one-time vacuum distillation. At this time, the main component of the distillate is water;

[0030] Step 3) Secondary vacuum distillation: adjust vacuum pump pressure -0.07Mpa; temperature 130°C, carry out secondary vacuum distillation until almost no distillate is evaporated. At this time, the main component of the distillate is L-ribose with a purity of 96% , the main residual component in the reactor is L-arabinose.

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PUM

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Abstract

The invention discloses a method for separating L-ribose. The method comprises the following steps: 1) adding L-arabinose, a catalyst and pure water into a reaction vessel, carrying out uniform mixing, then, adjusting a pH value to 3.0 to 5.0, adjusting the temperature to 100 DEG C to 120 DEG C, and carrying out a reaction for 2 to 5 hours in the reaction vessel, wherein the conversion ratio of isomerization is 25% to 35%; 2) feeding materials in the reaction vessel into distilling concentration equipment, and carrying out primary reduced-pressure distillation by adopting a vacuum pump until distillate is hardly distilled off and a main ingredient of the distillate is water; 3) regulating the pressure of the vacuum pump, carrying out secondary reduced-pressure distillation until distillateis hardly distilled off and a main ingredient of the distillate is water L-ribose, wherein the purity of the L-ribose is 92% to 98%, and a major residual ingredient in the reaction vessel is L-arabinose. According to the method, the separation of L-ribose from L-arabinose is carried out by adopting a reduced-pressure distillation method according to difference of boiling points of L-ribose and L-arabinose, the separating efficiency and purity of L-ribose are increased, and a production process method is simplified.

Description

technical field [0001] The invention relates to the technical field of sugar engineering, in particular to a method for separating L-ribose. Background technique [0002] L-ribose is an important sugar related to biological genetics. It plays a very important role in physiology. It is the constituent sugar of various ribonucleic acids and various nucleotide coenzymes. L-ribose is not found in nature and in organisms. It does not exist and is an extremely expensive rare sugar. L-ribose has good anti-tumor and anti-virus capabilities and has little toxic side effects on normal cells. L-ribose is also an important pharmaceutical synthesis intermediate. As L-ribose has shown strong potential as an intermediate of anti-AIDS and antiviral drugs, the global demand for L-ribose is increasing year by year with the continuous expansion of the application of L-ribose. [0003] Now the industrial preparation of L-ribose mainly adopts the chemical synthesis method, and L-arabinose is u...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H3/02C07H1/00C07H1/06
CPCC07H1/00C07H1/06C07H3/02
Inventor 孙鲁董铭邱学良黄伟红
Owner FUTASTE PHARM CO LTD