Flexible transferable surface-enhanced Raman detection substrate as well as preparation method and application thereof

A surface-enhanced Raman, transfer technology, applied in Raman scattering, nanotechnology for materials and surface science, measurement devices, etc. Simple method, high sensitivity effect

Inactive Publication Date: 2019-01-18
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] After searching the prior art, no similar prior art in this field was found

Method used

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  • Flexible transferable surface-enhanced Raman detection substrate as well as preparation method and application thereof
  • Flexible transferable surface-enhanced Raman detection substrate as well as preparation method and application thereof
  • Flexible transferable surface-enhanced Raman detection substrate as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Au@Ag NBs with smaller particle size were used to prepare flexible and transferable SERS substrates.

[0039] (1) Mix 5.0 ml 0.2 M CTAB with 5.0 ml 0.5 mM HAuCl 4 Mix, then add 0.6 ml of 0.01 M ice-cold NaBH with vigorous stirring 4 , prepare the seed solution, the seed solution is brown; add 5.0 ml 0.2 M CTAB solution to 0.2 ml 4 mM AgNO 3 solution, then add 5.0 ml 1.0 mM HAuCl 4 and 0.08 ml 0.08 M ascorbic acid to prepare a growth solution; measure 12 μL of the seed solution and add it to the above growth solution, and grow in a water bath at 30 °C for 2 hours to obtain a nanorod solution containing CTAB-capped Au nanorods.

[0040] (2) Centrifuge the nanorod solution at 7000 rpm for 20 minutes, separate the precipitate, and then disperse it in 10 ml of 80mM CTAC solution, then centrifuge the CTAC solution at 7000 rpm for 20 minutes, collect the precipitate, and then disperse the precipitate into 10 ml of 80 mM CTAC solution, repeat the steps of centrifugation and ...

Embodiment 2

[0044] Au@Ag NBs with medium particle size were used to prepare flexible and transferable SERS substrates.

[0045] Using the same steps as in Example 1, the mixture of 0.2 ml 0.01 M AgNO3 and 0.1 ml 0.1 M ascorbic acid in step 2 was replaced with 1 ml 0.01 M AgNO3 and 0.5 ml 0.1 M ascorbic acid The mixture, other steps and material dosages were unchanged, prepared A two-dimensional noble metal nano-superlattice film with a medium particle size of Au@Ag NBs was obtained and measured by TEM. The controllable optical properties of the film and the corresponding TEM morphology pictures are as follows: figure 2 as shown in b. It can be seen from the figure that its surface plasmon resonance absorption peak is at 590nm, and it has the strongest coupling electromagnetic field enhancement and detection signal in this wavelength range.

Embodiment 3

[0047] Au@Ag NBs with larger particle size were used to prepare flexible and transferable SERS substrates.

[0048] Using the same steps as in Example 1, the mixture of 0.2 ml 0.01 M AgNO and 0.1 ml 0.1 M ascorbic acid in step 2 was replaced with 2 ml 0.01 M AgNO3 and 1 ml 0.1 M ascorbic acid The mixture, other steps and material dosages were unchanged, prepared A two-dimensional noble metal nano-superlattice film with a larger particle size of Au@Ag NBs was obtained, and it was measured by TEM. The controllable optical properties of the film and the corresponding TEM morphology pictures are as follows: figure 2 as shown in c. It can be seen from the figure that its surface plasmon resonance absorption peak blue-shifts to 560nm, and has the strongest coupling electromagnetic field enhancement and detection signal in this wavelength range.

[0049] In combination with Examples 1-3, it can be seen that the size of nanoparticles can be dynamically adjusted to adjust the absorpt...

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Abstract

The invention provides a flexible transferable surface-enhanced Raman detection substrate as well as a preparation method and application thereof. The preparation method comprises the following steps:modifying thiolated polystyrene on noble metal nanoparticles by ligand exchange; and then assembling an ordered substrate-free self-supporting two-dimensional noble metal nanometer superlattice filmon a porous substrate by a gas-liquid interface self-assembly method to obtain a flexible transferable SERS (Surface Enhanced Raman Scattering) substrate. The substrate has an adjustable micro-structure and macro-optical performance, and has the characteristics of high detection sensitivity and high signal repeatability due to uniform magnetic field enhancement hot spots generated by the couplingbetween nanoparticles on a two-dimensional plane. A transfer technology based on PDMS as an elastic transparent carrier is adopted to transfer the SERS substrate to a complex morphology surface, so that instant high-sensitivity molecular detection can be performed on the complex morphology surface in a multi-phase environment, thereby solving the problem that a traditional SERS substrate is limited to a rigid or opaque support substrate.

Description

technical field [0001] The invention relates to a flexible and transferable surface-enhanced Raman detection substrate based on precious metal nanoparticles and its preparation method and application, which can be used for real-time transfer and detection of complex-morphological surfaces in a multi-phase environment, and belongs to the preparation technology of new nano-materials field. Background technique [0002] Surface-enhanced Raman scattering (SERS) is the enhancement of Raman scattering that relies on the localized surface plasmon resonance of noble metal plasmons. This enhancement of Raman spectroscopy can provide molecular detection for specific analytes. Since the discovery of this effect by Fleischmann et al. in 1974, surface-enhanced Raman spectroscopy has been widely used as a detection method in surface research, adsorption interface surface state research, interface orientation and configuration, conformation research, and structure research of biological ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/65B22F9/24B22F1/02B82Y30/00B82Y40/00
CPCG01N21/658B82Y30/00B82Y40/00B22F9/24B22F1/17
Inventor 陈怡殷豪景刘晃顾宁
Owner SOUTHEAST UNIV
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