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Urine protein marker for ovarian cancer and abdominal cavity transplantation tumors and diagnosis application thereof

A technology for transplanted tumors and ovarian cancer, applied in the field of clinical medicine, can solve the problems of low sensitivity and specificity

Inactive Publication Date: 2019-01-25
BEIJING NORMAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current clinical diagnostic methods include B-ultrasound examination, X-ray examination, CT and magnetic resonance examination, etc. The main screening methods are transvaginal ultrasonography, serum CA-125, etc. For a long time, although blood ovarian cancer markers, abdominal ultrasound Both ultrasonography and transvaginal ultrasonography are plagued by low sensitivity and specificity. Treatment methods such as surgery, radiotherapy, chemotherapy, and biological targeted therapy have improved, but the treatment effect and prognosis are poor. [4]
Despite the continuous development of diagnostic techniques for ovarian cancer in recent years, there are still many patients who cannot be diagnosed in the early stages of ovarian cancer with existing diagnostic techniques

Method used

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  • Urine protein marker for ovarian cancer and abdominal cavity transplantation tumors and diagnosis application thereof
  • Urine protein marker for ovarian cancer and abdominal cavity transplantation tumors and diagnosis application thereof
  • Urine protein marker for ovarian cancer and abdominal cavity transplantation tumors and diagnosis application thereof

Examples

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Embodiment 1

[0077] Example 1. Establishment of tumor animal models

[0078] 1. Nutu-19 rat ovarian cancer cells are derived from the same Fischer344 rat ovarian epithelial cancer cell line. The histological type is the most common clinical epithelial ovarian cancer serous papillary cystadenocarcinoma. The tumor growth mode and disease The progression process is also similar to that of clinical ovarian cancer, with disseminated growth in the pelvic cavity and abdominal cavity, resulting in death due to massive ascites, emaciation, and distant metastasis, which meets the clinical diagnostic criteria for epithelial ovarian cancer.

[0079] Using the animal model in which Nutu-19 rat ovarian cancer cells were intraperitoneally injected into Fischer344 rats, the process of ovarian cancer transplantation in the abdominal cavity was simulated, and the overall changes in the ovarian cancer abdominal transplantation tumors from early tumors, tumor progression and advanced tumors were observed. Cli...

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Abstract

The invention relates to a urine protein marker for ovarian cancer and abdominal cavity transplantation tumors and diagnosis application thereof, in particular to a urine protein marker obtained by using a rat ovarian cancer cell abdominal cavity transplantation tumor model and mass spectrometry, and application in diagnosis and disease course monitoring of human ovarian cancer and abdominal cavity transplantation tumors. The urine protein marker is selected from cell adhesion molecules 4, alcohol dehydrogenase 1, N(G), N(G)-dimethylarginine 1, methyl mercaptan oxidase, phosphotriesterase related protein, an Rab GDP dissociation inhibitor beta and the like. Urine differential protein obtained from the marker provides simpler, quicker and non-invasive choice for early diagnosis and diseasecourse monitoring of ovarian cancer and abdominal cavity transplantation tumors.

Description

technical field [0001] The invention relates to clinical medicine; in particular, it relates to a urine protein marker related to human ovarian cancer abdominal transplantation tumor. Specifically, the present invention relates to urine protein markers related to the diagnosis and / or monitoring of human ovarian cancer abdominal xenograft tumors obtained by using the rat disease model of epithelial ovarian cancer xenograft tumor and mass spectrometry analysis proteomics technology and its use . Background technique [0002] Disease biomarkers are measurable changes associated with pathophysiological processes, which are used to diagnose diseases, monitor disease course, predict disease prognosis, and evaluate treatment effects, etc. [0003] Urine, as the liquid excretion excreted by the body through the urinary system and urinary tract, is not regulated by the homeostasis mechanism, and can enrich the changes in the whole body, and is early and sensitive. Urine is an ideal ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68G01N30/02
CPCG01N33/68G01N30/02G01N33/6848
Inventor 高友鹤李育秋张琳珮
Owner BEIJING NORMAL UNIVERSITY
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