Establishment method for near-infrared quantitative correction model of Jingyaokang Capsule and detection method for Jingyaokang Capsule

A technology for constructing methods and calibrating models, which is applied to measuring devices, material analysis through optical means, instruments, etc., can solve the problems of high performance liquid chromatography, such as long detection time, low inspection efficiency, and complicated pretreatment, and achieve shortened The effect of testing and testing cycle, reducing testing costs, and efficient testing methods

Inactive Publication Date: 2019-02-15
JILIN MODERN TRADITIONAL CHINESE MEDICINE ENG RES CENT
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  • Summary
  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Sample pretreatment is complicated, time-consuming, labor-intensive, and costly, and the detection time of high-performance liquid chromatography is relatively long, which reduces the efficiency of inspection work

Method used

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  • Establishment method for near-infrared quantitative correction model of Jingyaokang Capsule and detection method for Jingyaokang Capsule
  • Establishment method for near-infrared quantitative correction model of Jingyaokang Capsule and detection method for Jingyaokang Capsule
  • Establishment method for near-infrared quantitative correction model of Jingyaokang Capsule and detection method for Jingyaokang Capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Embodiment 1 Determination of each index content of Jingyaokang Capsule

[0056] Determination method of strychnine content: according to the national drug standard

[0057] WS-10207(ZD-0207)-2002-2012Z detection, details are as follows:

[0058] Chromatographic conditions and system adaptability test use silica gel as filler; use n-hexane-dichloromethane-methanol-concentrated ammonia test solution (42.5:42.5:5.4:0.35) as mobile phase; detection wavelength is 254nm, and the number of theoretical plates is Strynin calculation should not be less than 6000.

[0059] Preparation of Reference Substance Solution Take an appropriate amount of strychnine reference substance, make it precise, add ethyl acetate to make a solution containing 50 μg per 1 ml, shake well, and get ready.

[0060] Preparation of the test solution Take the content of this product under the difference in loading amount, mix it evenly, take about 0.6g, make it precise, put it in a conical flask with a s...

Embodiment 2

[0075] Example 2 NIR Spectrum Collection of Contents of Jingyaokang Capsules

[0076] Take different batches of samples, pour them into the sample tank respectively, flatten and compact the sample with the matching tank cover, the thickness of the sample is 1.5cm, scan in the spectral range of 1100-2300nm, the scanning interval is 1.0nm, and the average number of scanning is 300 Second-rate. Each sample is collected 3 times, and the sample spectrum is obtained, such as Figure 5 shown.

Embodiment 3

[0077] Embodiment 3 spectral preprocessing

[0078] Before building a model, it is necessary to eliminate the influence of factors such as noise and baseline drift on spectral acquisition. Using the spectral processing program in the SNAP software, the original spectrum was preprocessed by the first-order differential 9-point smoothing method (Savitzky-Golay) to eliminate the spectral baseline shift and drift caused by factors such as color differences. Such as Figure 6 shown.

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Abstract

The invention relates to the field of drug detection, in particular to an establishment method for a near-infrared quantitative correction model of Jingyaokang Capsules and a detection method for Jingyaokang Capsules. The invention utilizes AOTF-NIR technology to establish NIR models of strychnine, hydroxysafflor yellow A, and moisture index of Jingyaokang Capsule finished products, which can simultaneously and quickly predict contents of multiple indexes in the finished products without cumbersome sample processing, and prediction results are accurate. The methods not only shorten a detectionperiod, reduce the use of consumables, and reduce detection costs, but also enable on-site analysis. And therefore, a fast and efficient detection method for the quality control of Jinguankang Capsules is provided. Compared with the traditional pharmacopoeia method, the methods greatly improve the analysis efficiency on the basis of ensuring the accuracy, and can quickly and efficiently control the product quality, thereby ensuring the safety, stability and effectiveness of the product quality.

Description

technical field [0001] The invention relates to the field of drug detection, in particular to a method for constructing a near-infrared quantitative correction model of Jingyaokang capsules and a detection method for Jingyaokang capsules. Background technique [0002] Jingyaokang Capsules are composed of 10 Chinese herbal medicines such as Nuxyma chinensis, Shenjincao, Xiangjiapi, Frankincense (stir-fried with vinegar), and safflower. It is used for fracture stasis, swelling pain, fracture recovery period, and arthralgia caused by kidney deficiency and blood stasis (hyperplastic spondylitis, lumbar disc herniation). The curative effect is definite and the market recognition is high. [0003] At present, in the existing technology of drug testing, high performance liquid chromatography is often used to detect the single index component of the sample, and determine the content of the effective component in it. Sample pretreatment is complicated, time-consuming, labor-intensi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/359G01N21/3563G01N30/02
CPCG01N21/3563G01N21/359G01N30/02
Inventor 王美慧高陆曲佳乐姜文月祁树贤徐杰边雨王雅俪李敏胡铭
Owner JILIN MODERN TRADITIONAL CHINESE MEDICINE ENG RES CENT
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