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Nanometer tea oil fatty acid calcium, iron and zinc complex, method for preparing same and application of nanometer tea oil fatty acid calcium, iron and zinc complex

A fatty acid calcium and compound technology, which is applied in the field of medicine, can solve problems such as poor stability, and achieve the effects of improving stability, facilitating industrial production, and mild reaction conditions

Inactive Publication Date: 2019-02-19
刘常春 +3
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, polyunsaturated fatty acids are easily oxidized and have poor stability. Combining with metal ions can improve their stability
And the method that camellia oil fatty acid calcium-iron-zinc complex is prepared by reacting camellia oil fatty acid with calcium, iron and zinc, and its application as the supplement of organic calcium, iron, zinc has not been reported

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A nanometer camellia oil fatty acid calcium-iron-zinc compound, wherein the components are as follows: 80% camellia oil fatty acid, 18% calcium, 1% zinc, and 1% iron.

[0025] The preparation method of above-mentioned nano-tea oil fatty acid calcium-iron-zinc complex: get 1kg tea oil and add the immobilized lipase of active unit 10000U, keep warm at 40 DEG C for 3h; let stand for stratification, get the upper layer oil liquid; use 3kg of 0.1% chlorine Rinse with sodium chloride aqueous solution, let stand to separate layers, and keep the upper layer of oil; add calcium oxide, zinc sulfate and ferrous sulfate in the formula, stir at 5000 rpm, and react at 50°C for 3 hours; pass through a 0.22m filter membrane and freeze-dry , to obtain 810 g of nano-tea oil fatty acid calcium-iron-zinc complex.

[0026] The particle size of the above-mentioned nano tea oil fatty acid calcium-iron-zinc complex is 260±18nm as measured by a nanometer particle size analyzer.

Embodiment 2

[0028] A nanometer camellia oil fatty acid calcium-iron-zinc compound, wherein the components are as follows: 95% camellia oil fatty acid, 3% calcium, 1% zinc, and 1% iron.

[0029] The preparation method of the above-mentioned nano-tea oil fatty acid calcium-iron-zinc complex: get 1kg tea oil and add an immobilized lipase with an active unit of 2000U, keep it warm at 50°C for 8h; let it stand for stratification, and take the upper layer of oil; use 0.5kg of 1% lipase Rinse with sodium chloride aqueous solution, let stand to separate layers, and keep the upper layer of oil; add the formula amount of calcium chloride, zinc chloride and ferrous chloride, stir at 20000 rpm, react at 70 °C for 1 hour; filter through 0.45m film, freeze-dried to obtain 730 g of nano-tea oil fatty acid calcium-iron-zinc complex.

[0030] The particle size of the above-mentioned nano tea oil fatty acid calcium-iron-zinc complex is 470±32nm as measured by a nanometer particle size analyzer.

Embodiment 3

[0032] A nanometer camellia oil fatty acid calcium-iron-zinc compound, wherein the components are as follows: 90% camellia oil fatty acid, 9.9% calcium, 0.05% zinc, and 0.05% iron.

[0033] Take 1 kg of camellia oil and add immobilized lipase with an active unit of 5000U, keep it warm at 45°C for 5 hours; let it stand for stratification, and take the upper layer of oil; rinse with 2 kg of 0.5% sodium chloride aqueous solution, stand for stratification, and keep the upper layer of oil solution; add calcium nitrate, zinc nitrate and ferrous carbonate in the formula, stir at 10000 rpm, and react at 60°C for 2h; pass through a 0.3m filter membrane, and freeze-dry to obtain 773g of nano-tea oil fatty acid calcium-iron-zinc complex.

[0034] The particle size of the above-mentioned nano tea oil fatty acid calcium-iron-zinc complex is 353±21nm as measured by a nanometer particle size analyzer.

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PUM

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Abstract

The invention discloses a nanometer tea oil fatty acid calcium, iron and zinc complex, a method for preparing the same and application of the nanometer tea oil fatty acid calcium, iron and zinc complex. The nanometer tea oil fatty acid calcium, iron and zinc complex comprises, by weight, 80-95% of tea oil fatty acid, 3-18% of calcium, 0.05-1% of zinc and 0.05-1% of iron. The method includes stepsof adding immobilized lipase into tea oil, preserving heat for a period of time, carrying out still standing and layering and acquiring upper-layer oil; carrying out leaching by sodium chloride aqueous solution, carrying to still standing and layering and reserving upper-layer oil; adding calcium salt, zinc salt and ferrous salt and carrying out reaction under the stirring conditions; filtering reaction products by filter membranes with certain sizes and carrying out freeze drying to obtain the nanometer tea oil fatty acid calcium, iron and zinc complex. The nanometer tea oil fatty acid calcium, iron and zinc complex can be used for preparing healthcare food or medicines for supplementing calcium, iron and zinc deficiency and preventing cardiovascular and cerebrovascular diseases. The nanometer tea oil fatty acid calcium, iron and zinc complex, the method and the application have the advantages that the stability of the fatty acid can be improved, calcium, iron and zinc absorption andutilization further can be promoted, and calcium, iron and zinc can be effectively utilized without mutual influence on absorption.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a nano-tea oil fatty acid calcium-iron-zinc complex and a preparation method and application thereof. Background technique [0002] Calcium, iron and zinc are essential elements for the human body and are especially important for the development of children. Deficiencies in calcium, iron, and zinc can lead to rickets, anemia, and dwarfism. Children's partial eclipse and less food may lead to calcium, iron and zinc deficiency. At present, the most common supplements for calcium, iron and zinc are glucose acid conjugates or inorganic salts, but the direct absorption and utilization rate of inorganic salts by the human body is low, and excessive intake of glucose can lead to obesity, induce diabetes, and promote dental caries In addition, intelligence may also be affected. [0003] Camellia oil is highly unsaturated and contains polyunsaturated fatty acids, known as "Oriental ...

Claims

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Application Information

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IPC IPC(8): A61K36/82A61P3/12A61P3/14A61P9/10A61P9/00A61K33/06A61K33/30A61K33/26
CPCA23V2002/00A61K33/06A61K33/26A61K33/30A61K36/82A23L33/115A23L33/16A61K2300/00A23V2200/326A23V2200/30A23V2250/186A23V2250/1578A23V2250/1592A23V2250/1642
Inventor 叶勇彭旗刘常春张忠杰范小娜刘运华刘思思何璇鄢志嵩赵闯张艳
Owner 刘常春
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