The invention discloses a fertilizer functional additive, a muskmelon special-use formula fertilizer and a preparation method thereof. The muskmelon special-use formula fertilizer is prepared from following components, in a blending manner, diammonium phosphate granules, ammonium nitrate phosphorus granules, potassium nitrate granules, potassium sulfate granules, magnesium sulfate monohydrate granules, zinc sulfate monohydrate granules and the fertilizer functional additive granule. The fertilizer functional additive granule is prepared from following components, in a compounding, mixing and granulating manner, EDTA calcium, EDTA iron, EDTA manganese, disodium octaborate tetrahydrate, sodium molybdate, anionic polyacrylamide, citric acid and poly amino polypeptide. The muskmelon special-use formula fertilizer has the excellent effects of regulating soil, activating nutrients, scientifically supplying nutrients, enhancing resistance and increasing yield and quality. The preparation method is simple, is low in consumption, and has a popularizing and applying value. The muskmelon special-use formula fertilizer has a high fertilizer efficiency, is reduced in use amount, can improve soil and increase fertilizer utilization rate, can increase the yield and improve the quality of muskmelons, can reduce production cost and is especially suitable for the tendency of zero-increase of chemical fertilizer use amount in modern agriculture.