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Dual channel exhalation analysis system for detecting lung cancer

A technology of analysis system and detection system, applied in analysis materials, biological material analysis, measurement devices, etc., can solve the problems of not fully reflecting the development of lung cancer disease, low detection efficiency, long production time, etc., so as to reduce the detection cost and time. Energy, good sensitivity, the effect of saving detection time

Active Publication Date: 2019-02-19
XUZHOU NORMAL UNIVERSITY
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  • Summary
  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

Doctoral thesis "Research on Rapid Non-Invasive Screening Method for Lung Cancer with Nano-gold-Porphyrin Composite Sensing Array" disclosed a 6×6 sensing array to realize the rapid identification of landmark organic volatiles in lung cancer exhalation and clinical exhalation samples However, not all of the 36 sensitive materials have the ability to identify lung cancer breath markers and clinical samples, and the production time is long, the detection cost is high, and the detection efficiency is low
In addition, there are trace amounts of disease-related components in clinical lung cancer breath samples, and conventional detection methods cannot fully reflect the development of lung cancer.

Method used

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  • Dual channel exhalation analysis system for detecting lung cancer
  • Dual channel exhalation analysis system for detecting lung cancer
  • Dual channel exhalation analysis system for detecting lung cancer

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Embodiment

[0021] The specific embodiments of the present invention will be briefly described below in conjunction with the accompanying drawings. Apparently, the described embodiments are only some of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other implementations obtained by those skilled in the art without creative work Examples, all belong to the protection scope of the present invention.

[0022] The preparation steps of the sensor array are as follows: 1) Basement membrane cutting: At room temperature (26°C), cut the hydrophobic PVDF membrane into a membrane with a size of 8 × 16mm, gently put it into the spotting mold with tweezers, and cover it. Mold cover with holes; 2) Chip spotting: In a nitrogen atmosphere, use a quartz capillary (inner diameter d≈0.3mm) to dip a saturated solution of ten sensitive substances (about 0.1uL) and apply it on the PVDF membrane. The technology allows sensitive substances to a...

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Abstract

The invention discloses a dual channel exhalation analysis system for detecting lung cancer. The invention comprises a gas filtration enrichment system, a secondary thermal desorption system and a sensing detection system. The sensing detection system comprises an air pump, a reaction chamber, an image capturing and processing system and a control system. The reaction chamber has two air passagesand two sensor chips. The two air passages are aligned with two columns of sensing materials. The sensing array is a 2x5 sensing array. Each sensing array has a image capturing and processing system on the top. The image capturing and processing system is connected to the control system. The sensor chip comprises a base film on which 10 kinds of sensitive substances are loaded. The dual channel exhalation analysis system for detecting lung cancer of the invention has better sensitivity, accuracy and repeatability, shortens detection time and reduces cost, and can be used for extensive screening and prognosis monitoring of lung cancer diseases.

Description

technical field [0001] The invention relates to a disease detection device, in particular to a dual-channel breath analysis system for detecting lung cancer. Background technique [0002] Lung cancer is one of the most common malignant tumors, and its high morbidity and mortality seriously threaten human health. In view of the fact that lung cancer has no obvious symptoms in the early stage and is easily ignored by patients and doctors, most of the diagnosed patients are already in the middle and advanced stages and have a short survival time. Although traditional lung cancer diagnostic methods such as imaging detection, pathological detection, and microscopic examination have certain effects, they still have limitations such as invasiveness, high false negative / positive, and high cost. When the human body breeds lung cancer, cancer cells will produce certain marker substances, these chemical components are discharged into the blood, and then exchanged through the lungs, re...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/574
CPCG01N33/574G01N33/57423G01N2800/12
Inventor 徐永红李荣鹏蒋继宏任建国
Owner XUZHOU NORMAL UNIVERSITY