Controlled-release pharmaceutical composition for treating thyroid dysfunction
A technology for thyroid function and controlled release of drugs, which is applied in the field of composition of new preparations, and can solve problems such as deterioration of cardiac function, induction, and unfixed T4/T3 ratio
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Embodiment 1
[0037]
[0038] In a 3000ml flask, add ethylcellulose in 500ml of water, and add a solution of liothyronine in 1000ml of water with continuous stirring, after mixing well, add sodium lauryl sulfate, disodium hydrogen phosphate and magnesium stearate , keep stirring at room temperature until the suspension is completely homogeneous. Put 750g of blank ball cores into the fluidized bed, and spray with the pre-prepared suspension under the following conditions: air flow: 200 cubic meters per hour, nozzle diameter: 1.0mm , Injection pressure: 0.85bar, injection of suspension: 35g / min, fluidized bed temperature: 50°C.
[0039] In a 3000 ml flask, prepare an aqueous homogeneous dispersion of Tween-80, triethyl citrate, natural carotene and Eudragit-L in purified water, and add sodium lauryl sulfate and talc, and keep stirring at room temperature until mixed The suspension is completely homogeneous. Put the single-layer coated drug-loaded pellets into the fluidized bed, and spray ...
Embodiment 2
[0042]
[0043]In a 3000ml flask, add ethylcellulose in 500ml of water, and add a solution of liothyronine in 1000ml of water with continuous stirring, after mixing well, add sodium lauryl sulfate, disodium hydrogen phosphate and magnesium stearate , keep stirring at room temperature until the suspension is completely homogeneous. Put 750g of blank ball cores into the fluidized bed, and spray with the pre-prepared suspension under the following conditions: air flow: 200 cubic meters per hour, nozzle diameter: 1.0mm , injection pressure: 0.85 bar, injection of suspension: 35 g / min, fluidized bed temperature: 60°C.
[0044] In a 3000 ml flask, prepare an aqueous solution of Tween-80, triethyl citrate, cochineal and Eudragit-L uniformly dispersed in purified water, and add sodium lauryl sulfate and talc, and keep stirring at room temperature until mixed. The suspension is completely homogeneous. Put the single-layer coated drug-loaded pellets into the fluidized bed, and spray...
Embodiment 3
[0047]
[0048] In a 1500 ml flask, add ethyl cellulose in 500 ml of water, and add a solution of liothyronine in 500 ml of water with continuous stirring, after mixing well, add sodium lauryl sulfate, disodium hydrogen phosphate and magnesium stearate , keep stirring at room temperature until the suspension is completely homogeneous. Put 750g of blank ball cores into the fluidized bed, and spray with the pre-prepared suspension under the following conditions: air flow: 200 cubic meters per hour, nozzle diameter: 1.0mm , injection pressure: 0.85 bar, injection of the suspension: 25 g / min, fluidized bed temperature: 50°C.
[0049] In a 1500 ml flask, prepare a 95% ethanol homogeneous dispersion of Tween-80, triethyl citrate, natural carotene, and shellac, and add sodium lauryl sulfate and talc, and keep stirring at room temperature until suspended The liquid is completely uniform. Put the single-layer coated drug-loaded pellets into the fluidized bed, and spray with the pre-...
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