Huperzine A sustained-release pellets coated granules, sustained-release pellets and preparation method thereof

A technology for sustained-release pellets and huperzine A, applied to sustained-release pellets and preparation thereof, in the field of huperzine A sustained-release pellets coated granules, which can solve the problem of low friction force and uniform content in compressed tablets. Sexual influence, stratification and other issues, to achieve a good drug experience, good drug content uniformity, and reduce the number of drugs

Active Publication Date: 2019-02-26
GUANGZHOU NEWORLD PHARMA CO LTD
View PDF5 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preparation of sustained-release pellets is relatively difficult. The main difficulty is that the surface of the pellets is a more regular spherical shape, and the friction with the tableting auxiliary materials is small. In the process of mixing with the tableting auxiliary materials, it is easy Stratification occurs, which greatly affects the content uniformity of compressed tablets

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Huperzine A sustained-release pellets coated granules, sustained-release pellets and preparation method thereof
  • Huperzine A sustained-release pellets coated granules, sustained-release pellets and preparation method thereof
  • Huperzine A sustained-release pellets coated granules, sustained-release pellets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0078] Example 1 Preparation of Huperzine A sustained-release pellets

[0079] The formula of Huperzine A sustained-release pellets provided in this example is shown in Table 1.

[0080] Table 1

[0081]

[0082] The preparation method of the Huperzine A sustained-release pellets of the present embodiment comprises the following steps:

[0083] Dissolve the adhesive and additives in purified water according to the formula and dosage in Table 1, and use the resulting solution as a wetting agent; then mix the wetting agent with Huperzine A, sustained-release materials and pellet-making auxiliary materials to prepare a soft material; using an extrusion spheronizer to prepare the soft material into pellets, drying, and sieving.

Embodiment 2

[0085] 1. Preparation of Huperzine A Sustained-Release Pellets Coated Granules

[0086] The formula of Huperzine A sustained-release pellet coated granules provided in this example is shown in Table 2.

[0087] Table 2

[0088]

[0089] The preparation method of Huperzine A sustained-release pellet coated granules of the present embodiment comprises the following steps:

[0090] (1) dissolving the binder in purified water to obtain a binder solution;

[0091] (2) Mix the microcrystalline cellulose PH-302, corn starch, lactose and sodium carboxymethyl starch evenly;

[0092] (3) the huperzine A sustained-release pellets are placed in the centrifugal granulator, the rotating speed of opening the centrifugal granulator is 400 rpm, after the huperzine A sustained-release pellets are in a centrifugal state, according to 10g / min The adhesive solution was sprayed at the liquid supply speed, and the uniformly mixed coating auxiliary materials were placed in the feeding hopper at...

Embodiment 3

[0100] 1. Preparation of Huperzine A Sustained-Release Pellets Coated Granules

[0101] The formulation of Huperzine A sustained-release pellet coated granules provided in this example is shown in Table 4.

[0102] Table 4

[0103]

[0104] The preparation method of the Huperzine A sustained-release pellet coated granules in this example is the same as that in Example 2.

[0105] 2. Preparation of Huperzine A Sustained-Release Pellets

[0106] The coated granules of Huperzine A sustained-release pellets prepared in this example are further prepared into Huperzine A sustained-release pellets, and the formula and preparation method thereof are the same as those in Example 2.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Diameteraaaaaaaaaa
Login to view more

Abstract

The invention relates to huperzine A sustained-release pellets coated granules, sustained-release pellets and a preparation method thereof. The huperzine A sustained-release pellets coated granules ofthe present invention are prepared from the following raw materials in parts by weight: 100 parts of huperzine A sustained-release pellets, 5-15 parts of a binder A, and 55-75 parts of coating auxiliary materials. The binder A is hydroxypropyl cellulose; the coating auxiliary materials are composed of the following components in parts by weight: 20-30 parts of microcrystalline cellulose, 10-20 parts of corn starch, 10-20 parts of lactose, and 10 parts of carboxyl methyl starch sodium. The huperzine A sustained-release pellets coated granules of the invention have the high-roughness pellet surface, and have a slow and stable release effect. The huperzine A sustained-release pellets prepared by further preparation of the huperzine A sustained-release pellets coated granules have good drug content uniformity and have the sustained release effect similar to that of the sustained-release pellets coated granules.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a Huperzine A sustained-release pellet-coated granule, a sustained-release pellet tablet and a preparation method thereof. Background technique [0002] Huperzine A is a drug for the treatment of middle-aged and elderly benign memory disorders and various types of dementia, memory cognitive function and emotional behavior disorders. The drug has high biological activity, has high lipid solubility, easily penetrates the blood-brain barrier, and is distributed in the brain areas closely related to learning and memory after entering the central nervous system. At low doses, acetylcholinesterase ( AchE) has a strong inhibitory effect, which significantly increases the content of acetylcholine (Ach) in the synaptic space in the distribution area, thereby enhancing neuronal excitation conduction, strengthening the excitation effect of learning and memory brain areas...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K9/50A61K31/4748A61K47/38A61K9/26A61P25/28A61P25/00
CPCA61K9/1652A61K9/2077A61K9/2095A61K9/5042A61K31/4748
Inventor 陈航平李革杨思超张敏敏
Owner GUANGZHOU NEWORLD PHARMA CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap