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Huperzine A sustained-release pellets and preparation method thereof

A technology of huperzine A and sustained-release pellets is applied in the directions of pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc., and can solve the problem of reducing single dose, taking less medicine or taking more medicine , memory function decline and other problems, to achieve good drug content uniformity, good compatibility and good formability.

Active Publication Date: 2020-11-13
GUANGZHOU ZHONGDA NANSHA TECH INNOVATION IND PARK
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For common non-sustained-release preparations, which release rapidly, in order to maintain a lower blood concentration, only a single dose can be reduced and multiple doses are required.
Commercially available huperzine A solid preparations include tablets and capsules. The content of a single tablet or a single capsule is 50 μg, which needs to be taken multiple times a day, and most of the drug users are middle-aged and elderly people with poor memory function. decreased, leading to the phenomenon of under-dosing or over-dosing, which poses certain safety hazards

Method used

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  • Huperzine A sustained-release pellets and preparation method thereof
  • Huperzine A sustained-release pellets and preparation method thereof
  • Huperzine A sustained-release pellets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] The formula of the huperzine A sustained-release pellets of the present embodiment is shown in Table 1.

[0039] Table 1

[0040]

[0041] The preparation method of the huperzine A sustained-release pellets of the present embodiment may further comprise the steps:

[0042] Dissolve binder and additives in purified water according to the formula and dosage in Table 1, and the resulting solution is used as wetting agent; then the wetting agent is mixed evenly with huperzine A, slow-release materials and pelleting auxiliary materials, and prepared into soft material; the soft material is prepared into pellets by an extrusion spheronizer, dried and sieved to obtain the product.

Embodiment 2

[0044] The formula of the huperzine A sustained-release pellets of the present embodiment is shown in Table 2.

[0045] Table 2

[0046]

[0047] The preparation method of the huperzine A sustained-release pellets of the present embodiment is the same as that in Example 1.

Embodiment 3

[0049] The formula of the huperzine A sustained-release pellets of the present embodiment is shown in Table 3.

[0050] table 3

[0051]

[0052]

[0053] The preparation method of the huperzine A sustained-release pellets of the present embodiment is the same as that in Example 1.

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Abstract

The invention relates to huperzine A sustained-release pellets and a preparation method thereof. The huperzine A sustained-release pellets are prepared from the following raw materials by weight percentage: 0.05-0.4% of huperzine A, 45-65% of a sustained-release material, 2-9% of an addictive, 2-15% of a binder, and 20-40% of a pelleting auxiliary material. The sustained-release material is composed of ethyl cellulose and stearic acid in a mass ratio of 1 to 3:1; the additive is selected from at least one of poloxamer, polyethylene glycol, and triethyl citrate; the binder is hydroxypropyl cellulose; the pelletizing auxiliary material is selected from at least one of microcrystalline cellulose, lactose, pregelatinized starch, and mannitol. The huperzine A sustained-release pellets of the invention have the slow and stable release effect, and the dissolution is relatively complete, the pellets have good content uniformity, good roundness, and concentrated particle size distribution, which is convenient for further preparation development.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a huperzine A sustained-release pellet and a preparation method thereof. Background technique [0002] Huperzine A is a multi-target natural drug with outstanding efficacy and good stability. It can be used to treat Alzheimer's disease, memory and cognitive dysfunction and other diseases. It has the characteristics of high biological activity and easy penetration of the blood-brain barrier. , the principle of action is that Huperzine A combines with acetylcholinesterase in the body, inhibits its physiological activity, reduces the degradation of acetylcholine in the brain, thereby increasing the level of acetylcholine in the brain, and achieves the effect of improving the symptoms related to Alzheimer's disease. [0003] Huperzine A has the characteristics of low dose and high efficiency, and better effect can be achieved by maintaining a low blood concentrati...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K31/4748A61K47/38A61K47/10A61K47/12A61K47/14A61P25/28
CPCA61K9/0002A61K9/1617A61K9/1641A61K9/1652A61K31/4748
Inventor 吴传斌陈航平张林杰彭婷婷黄莹
Owner GUANGZHOU ZHONGDA NANSHA TECH INNOVATION IND PARK
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