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A kind of preparation method of tetrasodium aspartic acid diacetate

A technology of tetrasodium aspartate diacetate and aspartic acid, which is applied in the preparation of organic compounds, cyanide reaction preparation, chemical instruments and methods, etc., can solve the problems of low yield and the like, and improve the reaction yield , The effect of stable product quality and short reaction period

Active Publication Date: 2021-11-12
SHANDONG TAIHE WATER TREATMENT TECH CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method requires highly toxic hydrocyanic acid as a raw material, accompanied by a large amount of by-products that are difficult to separate or produces a large amount of corrosive waste water, and the yield is low

Method used

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  • A kind of preparation method of tetrasodium aspartic acid diacetate

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Effect test

Embodiment 1

[0028] (1) Add 201.5g of L-aspartic acid, 100g of 30% aqueous sodium hydroxide solution and 75g of deionized water into the reaction kettle, stir and mix evenly, and the neutralization degree of L-aspartic acid is about 50%;

[0029] (2) Dissolve 315g of chloroacetic acid in 220g of deionized water, and put it into a constant pressure dropping funnel for later use;

[0030] (3) 655g mass percentage composition is 45% sodium hydroxide aqueous solution and is put into another constant pressure dropping funnel for subsequent use;

[0031] (4) Raise the temperature of the reactor system to 85°C, and add dropwise the aqueous solution of chloroacetic acid in step (2) and the liquid caustic soda in step (3), and control the rate of addition so that the temperature of the reaction system is at 85-90°C and pH The value is maintained at 10.5-11, and the dropwise addition is completed in 1.5 hours; while the dropwise addition reaction is started, under the negative pressure condition of ...

Embodiment 2

[0035] (1) Add 134g of L-aspartic acid, 107g of 30% sodium hydroxide aqueous solution and 50g of deionized water into the reaction kettle, stir and mix evenly, and the neutralization degree of L-aspartic acid is about 80%;

[0036] (2) Dissolve 200g of chloroacetic acid in 141g of deionized water and put it into a constant pressure dropping funnel for later use;

[0037] (3) 460g mass percentage content is 40% sodium hydroxide aqueous solution and is put into another constant pressure dropping funnel for subsequent use;

[0038] (4) Raise the temperature of the reactor system to 80°C, and at the same time add dropwise the aqueous solution of chloroacetic acid in step (2) and the liquid caustic soda in step (3), and control the rate of addition so that the temperature of the reaction system is at 80-85°C and the pH The value is maintained at 10-10.5, and the dropwise addition is completed in 1 hour; at the same time as the dropwise addition reaction is started, under the negati...

Embodiment 3

[0042] (1) Add 134g of L-aspartic acid, 80g of 30% sodium hydroxide aqueous solution and 50g of deionized water into the reaction kettle, stir and mix evenly, and the neutralization degree of L-aspartic acid is about 60%;

[0043] (2) Dissolve 219.5g of chloroacetic acid in 155g of deionized water, and put it into a constant pressure dropping funnel for later use;

[0044] (3) 445g mass percentage composition is that 45% sodium hydroxide aqueous solution is packed into another constant pressure dropping funnel for subsequent use;

[0045] (4) Raise the temperature of the reactor system to 85°C, and add dropwise the aqueous solution of chloroacetic acid in step (2) and the liquid caustic soda in step (3), and control the rate of addition so that the temperature of the reaction system is at 85-90°C and pH The value is maintained at 11-11.5, and the dropwise addition is completed in 1 hour; while the dropwise addition reaction is started, under the negative pressure condition of ...

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Abstract

The invention provides a novel preparation method of tetrasodium aspartic acid diacetate. Specifically, under certain temperature conditions, the partially neutralized natural amino acid L-aspartic acid is used as a raw material, and SN2 bimolecular nucleophilic substitution reaction occurs with chloroacetic acid under alkaline conditions to prepare tetrasodium aspartic acid diacetate. Among them, chloroacetic acid and sodium hydroxide are added dropwise into the kettle, and the pH value of the reaction system is controlled in the range of 9~12. At the same time, the reaction process is under the condition of 0~-0.005MPa negative pressure, and the water in the reaction system is removed in time to maintain Reaction material concentration, improve conversion rate and reaction rate. The method of the invention has short reaction period, simple production process, and the yield can reach 99%. The produced water can be recycled, no toxic by-products and waste water are produced, safe and environment-friendly, and easy to realize large-scale industrial production.

Description

technical field [0001] The invention belongs to the field of organic chemistry and provides a preparation method of tetrasodium aspartic acid diacetate. Background technique [0002] In recent years, due to water eutrophication, environmental changes, and global warming, green environmental protection has once again become an issue of public life. Green products and low-carbon emissions have also become a trend in the industry. Detergents, which are closely related to people's daily life, are often used to soften washing water, and their main additives are chelating agents that chelate metal ions such as calcium, magnesium, and iron in water. The use of chelating agents can reduce the hardness of water, save the amount of detergent active substances, and improve the washing effect of clothes. However, commonly used chelating agents such as phosphates, hydroxy acids, amino acids, and acrylic polymers have negatively affected people's living environment to some extent. The d...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C227/18C07C229/24
CPCC07C227/18C07C229/24
Inventor 王宁宁赵坤陆久田赵芹齐晓婧刘全华
Owner SHANDONG TAIHE WATER TREATMENT TECH CO LTD
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