Method for removing peptidoglycan from starch hydrolysate

Abstract

The invention provides a method for removing peptidoglycan from a starch hydrolysate. The method is characterized by comprising the following steps: (1) activated carbon is dispersed in 5 times or above of water, hydrochloric acid is added to adjust the pH of a solution to be 1.0-3.0, heating is conducted to 60 DEG C or above, stirring is conducted for 0.5-2 h, and filtering is conducted till thesolution is dried; (2) the treated activated carbon is put into the starch hydrolysate and heated to 90 DEG C or above, and stirring heat preservation is conducted for 0.5-1 h; and then (3) a starch hydrolysate aqueous solution is obtained through filtration, and the starch hydrolysate is subjected to spray drying to obtain a solid product. The content of the solid peptidoglycan detected by a silkworm plasma reagent is lower than 2 ng / g. According to the method, the cost is extremely low, the small amount of activated carbon and the small amount of hydrochloric acid are used, the adsorption efficiency of the activated carbon can be greatly improved, and compared with other methods, the cost is minimal.

Description

technical field [0001] The invention belongs to the field of synthesis of chemical raw materials, in particular to a method for removing peptidoglycan from starch hydrolyzate. Background technique [0002] Peritoneal dialysis (PD) uses the patient's peritoneum as a semipermeable membrane, injects peritoneal fluid into the peritoneal cavity, and uses the solute concentration gradient and osmotic gradient between the plasma and the peritoneal fluid to remove nitrogen metabolism and renal excretion under normal circumstances. Toxic substances in the body, and help to regulate body fluids, electrolytes and acid-base balance, as a method for treating patients with end stage renal disease (ESRD), due to its home treatment, easy to operate, reduce It has been widely used in recent years because of its special advantages such as the transmission of blood-borne diseases and the protection of residual renal function. [0003] Using glucose as the osmotic agent, glucose as the osmotic...

AI Technical Summary

Problems solved by technology

However, the amount of peptidoglycan adsorbed by this method is limited, and even if the amount of ion exchange resin is greatly increased, it cannot meet the requirements at all.

This is mainly due to the fact that although peptidoglycan is negatively charged, it cannot be completely adsorbed due to the large molecule and weak electrical property.

[0010] The conventional method of physical adsorption is activated carbon adsorption. Activated carbon adsorption is generally used at the end of raw materials and preparations to control product endotoxins. Since the issue of peptidoglycan has not been paid attention to in China, research on the decolorization of peptidoglycan is seldom carried out.