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Method for removing endotoxin in starch hydrolysate

A starch hydrolyzate and endotoxin technology, applied in water pollutants, chemical instruments and methods, water/sewage treatment, etc., to achieve the effects of easy popularization and application, simple operation, and improved adsorption activity

Inactive Publication Date: 2019-01-25
HUAREN PHARMACEUTICAL CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

None of the aforementioned methods for removing endotoxins can make the endotoxins in the product reach an acceptable level

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach

[0027] An embodiment of the method for removing endotoxin in starch hydrolyzate of the present invention comprises the following steps:

[0028] (1) Activated carbon is dispersed in more than 5 times of water, adding hydrochloric acid to adjust the pH of the solution between 1.0 and 3.0, heating to above 60°C, stirring for 0.5 to 2 hours, filtering, washing with water, and drying;

[0029] (2) Put the treated activated carbon into the starch hydrolyzate solution, heat it to above 90°C, stir and keep it warm for 0.5~1h, release the hydrogen chloride adsorbed during the treatment through the activated carbon, and make the pH of the solution reach 3.0~4.0, under this condition , can enhance the adsorption capacity of activated carbon, and will not cause the secondary hydrolysis of starch hydrolyzate due to the reduction of acidity, and keep the molecular weight of the product unchanged.

[0030] (3) Then, by filtering, an aqueous starch hydrolyzate solution is obtained, and the a...

Embodiment 1

[0034] Add 30L of purified water and 3kg of activated carbon to the 50L reaction kettle, add hydrochloric acid to adjust the pH to 1.5, turn on the heating, heat to 60°C, and keep stirring for 1h. Filter under reduced pressure to obtain pretreated activated carbon.

[0035] Add the pretreated activated carbon into the icodextrin feed liquid (about 1200L feed liquid contains 200kg icodextrin), heat to above 90°C, keep warm for 0.5h and then filter, the filtrate is detected by gel method, and the endotoxin content is lower than 0.06Eu / ml.

Embodiment 2

[0037] Add 30L of purified water and 3kg of activated carbon to the 50L reaction kettle, add hydrochloric acid to adjust the pH to 1.0, turn on the heating, heat to 60°C, and keep stirring for 1h. Filter under reduced pressure to obtain pretreated activated carbon.

[0038] Add the pretreated activated carbon into the icodextrin feed liquid (about 1200L feed liquid contains 200kg icodextrin), heat to 90°C, keep warm for 0.5h and then filter, the filtrate is detected by gel method, and the endotoxin content is lower than 0.06 Eu / ml.

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Abstract

The invention provides a method for removing endotoxin in starch hydrolysate. The method is characterized by comprising the following steps that (1) activated carbon is dispersed in water of 5 times or more, hydrochloric acid is added to adjust the pH of a solution to be 1.0-3.0, and the solution is heated to 60 DEG or above, stirred for 0.5-2 h, filtered, washed with water and filter-dried; (2) treated activated carbon is put into a starch hydrolysate solution, the mixed solution is heated to 90 DEG C or above, stirred and subjected to heat preservation for 0.5-1 h, and hydrogen chloride adsorbed in the treatment process is released by the activated carbon to make the pH of the solution reach 3.0-4.0; (3) the solution is filtered to obtain an aqueous starch hydrolysate solution, and the aqueous starch hydrolysate solution is spray-dried to obtain a starch hydrolysate solid. By means of the method, the content of endotoxin in starch hydrolysate can reach the level required by the pharmacopoeia.

Description

technical field [0001] The invention belongs to the field of synthesis of chemical raw materials, in particular to a method for removing endotoxin in starch hydrolyzate. Background technique [0002] Peritoneal dialysis (PD) uses the patient's peritoneum as a semipermeable membrane, injects peritoneal fluid into the peritoneal cavity, and uses the solute concentration gradient and osmotic gradient between the plasma and the peritoneal fluid to remove nitrogen metabolism and renal excretion under normal circumstances. Toxic substances in the body, and help to regulate body fluids, electrolytes and acid-base balance, as a method for treating patients with end stage renal disease (ESRD), due to its home treatment, easy to operate, reduce It has been widely used in recent years because of its special advantages such as the transmission of blood-borne diseases and the protection of residual renal function. [0003] Using glucose as the osmotic agent, glucose as the osmotic agent...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C02F1/28B01J20/30B01J20/20C08B30/18C02F101/20
CPCB01J20/20C02F1/281C02F2101/20C08B30/18
Inventor 袁博冯新光卞常鑫叶芳
Owner HUAREN PHARMACEUTICAL CO LTD
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