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Biological dosimeter and neutron capture treatment system including same

A biological dose and treatment system technology, applied in dosimeter, treatment, biological material analysis, etc., can solve the problems of personal safety threats to patients or medical staff, long radiation time of patients, complicated operation procedures, etc., and improve the sensitivity of dose measurement , high sensitivity and accuracy, the effect of high sensitivity

Active Publication Date: 2019-03-01
NEUBORON MEDTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the process of using BNCT technology for disease treatment, the neutron dose is too low to make the boron-containing compound in the lesion fully react with neutrons, and the patient needs to receive radiation for a long time; the neutron dose is too high often accompanied by gamma rays or The pollution of other radiation sources poses a threat to the personal safety of patients or medical staff. Therefore, it is necessary to pre-evaluate the radiation dose received by the patient before neutron irradiation, so as to complete the treatment on the premise that the patient suffers the least radiation damage. patient treatment
[0006] Currently known biological dosimeters mainly use the effect of radiation on RNA transcription or protein expression to measure the dose received by biomolecules, but these techniques usually require a series of complicated steps such as cell culture, protein separation, and calculation. Complicated, prone to errors

Method used

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  • Biological dosimeter and neutron capture treatment system including same
  • Biological dosimeter and neutron capture treatment system including same
  • Biological dosimeter and neutron capture treatment system including same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] The drawing of biological dosimeter standard curve

[0051] The standard curve drawn by the biological dosimeter provided by the present invention can be drawn according to the degree of degradation of the protein in any kind of radiation field, and the present embodiment draws the standard curve with the degree of degradation of bovine serum albumin in the gamma radiation field as an example Describe how to draw a standard curve.

[0052] Different concentrations of proteins have different degrees of degradation in the radiation field, and protein concentration is a factor that affects the degree of degradation in the radiation field. The following is a standard curve drawn with the degradation degrees of different concentrations of proteins in the gamma radiation field to further illustrate .

[0053] Concentration is the drawing of the standard curve of the bovine serum albumin solution in the gamma radiation field of 0.3g / L:

[0054] Dissolve 0.03g of BSA in 100g...

Embodiment 2

[0074] biological dosimeter measures neutron and the method for gamma mixed radiation field actual radiation dose

[0075] When measuring the radiation field intensity with a biological dosimeter, a standard curve between the degree of protein degradation and radiation dose can be made in advance based on the type of radiation field to be measured, or a standard curve made by a non-radiation field to be measured can be used and the radiation field to be measured and the radiation dose can be used. The conversion coefficient of the radiation field used by the standard curve is used to measure the actual radiation dose of the radiation field to be measured.

[0076] The conversion coefficient between radiation fields needs to be further confirmed through experiments. This embodiment uses the calculation method of conversion coefficient between gamma radiation field and neutron radiation field as an example to illustrate the calculation method of conversion coefficient between di...

Embodiment 3

[0086] The neutron capture therapy system comprising a biological dosimeter

[0087] The biological dosimeter provided by the embodiment of the present invention is used to detect radiation dose, not only can be used to detect radiation pollution in the environment, but also can be used in neutron capture therapy system to estimate the intensity or dose of neutron beam to guide Healing.

[0088] The application of neutron capture therapy as an effective means of treating cancer has gradually increased in recent years, among which boron neutron capture therapy is the most common, and neutrons supplying boron neutron capture therapy can be supplied by nuclear reactors or accelerators. The embodiment of the present invention takes the accelerator boron neutron capture therapy as an example, and the basic components of the accelerator boron neutron capture therapy generally include an accelerator for accelerating charged particles (such as protons, deuterons, etc.), targets and h...

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Abstract

A biological dosimeter, a method of using the same, and a neutron capture treatment system including the biological dosimeter are provided. The biological dosimeter measures a dose received by a protein in a radiation field based on the degree of degradation of the protein in the radiation field. The biological dosimeter has simple operation, few steps and a small error, and can measure the radiation dose of various radiation fields and even a mixed radiation field. The use of the biological dosimeter in the neutron capture treatment system can evaluate not only the radiation pollution in an irradiation chamber, but also a neutron dose.

Description

technical field [0001] One aspect of the present invention relates to the field of radiation dosimetry, in particular to a biological dosimeter and its use method; another aspect of the present invention relates to the field of radiation exposure, in particular to a neutron capture therapy system with a biological dosimeter. Background technique [0002] With the development of science and technology, nuclear technology has been widely used in various fields such as medicine, industry, agriculture, etc. While benefiting mankind, nuclear technology also has a certain risk of nuclear leakage, endangering public health and polluting the surrounding environment. Therefore, it is necessary to determine the radiation dose in the environment to further evaluate the impact of radiation dose on humans or the environment, and to take certain control measures for the radiation dose in the environment. [0003] The application of neutron capture therapy as an effective means of treating...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01T1/02A61N5/10
CPCA61N5/10A61N5/1048G01T1/02A61N2005/109G01N33/6803A61N5/1075A61N5/1071G01N2333/765
Inventor 刘渊豪陈瑞芬何静萧明城
Owner NEUBORON MEDTECH
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