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Neutron capture therapy (NCT) is a noninvasive therapeutic modality for treating locally invasive malignant tumors such as primary brain tumors, recurrent head and neck cancer, and cutaneous and extracutaneous melanomas. It is a two-step procedure: first, the patient is injected with a tumor-localizing drug containing the non-radioactive isotope boron-10 (¹⁰B), which has a high propensity to capture thermal neutrons. The cross section of the ¹⁰B (3,837 barns) is many times greater than that of the other elements present in tissues such as hydrogen, oxygen, and nitrogen. In the second step, the patient is radiated with epithermal neutrons, the source of which is either a nuclear reactor or, more recently, an accelerator. After losing energy as they penetrate tissue, the neutrons are captured by the ¹⁰B, which subsequently emits high-energy alpha particles that can selectively kill those tumor cells that have taken up sufficient quantities of ¹⁰B. All of the clinical experience to date with NCT is with the non-radioactive isotope boron-10, and this is known as boron neutron capture therapy (BNCT). At this time, the use of other non-radioactive isotopes, such as gadolinium, has been limited to experimental studies, and to date, it has not been used clinically. BNCT has been evaluated clinically as an alternative to conventional radiation therapy for the treatment of high-grade gliomas, meningiomas, and recurrent, locally advanced cancers of the head and neck region and superficial cutaneous and extracutaneous melanomas.
Beam shaper for neutron-capture therapy
The invention provides a beam shaper for neutron-capture therapy in order to improve flux and quality of a neutron source. The beam shaper comprises a target, a slowing body adjacent to the target, a reflector wrapping the slowing body, a thermal neutron absorber adjacent to the slow body, a radiation shield arranged in the beam shaper and a beam outlet. The target generates nuclear reaction with a proton beam incident from a beam inlet so as to generate neutrons, the neutrons form a neutron beam which defines a main axis, the slowing body slows down the neutrons generated from the target to an epithermal neutron energy region, the reflector guides the neutrons deviating from the main axis to the main axis so as to improve intensity of the epithermal neutron beam, a gap passage is arranged between the slowing body and the reflector so as to improve epithermal neutron flux, the thermal neutron absorber is used for absorbing the thermal neutron so as to avoid causing overmuch dosed with shallow normal tissue during therapy, and the radiation shield is used for shielding leaked neutrons and photon so as to reduce normal tissue dose in a non-radiation region.
Owner:NEUBORON MEDTECH
Beam shaping body for neutron capture therapy
In order to improve the flux and the quality of a neutron source, the invention provides a beam shaping body for neutron capture therapy. The beam shaping body comprises a beam inlet, a target, a retarding body adjacent to the target, a reflecting body surrounding the external of the retarding body, a thermal neutron absorber adjacent to the retarding body, and a radiation shield and a beam outlet formed in the beam shaping body, wherein the target has nuclear reaction with proton beam entering from the beam inlet, so as to produce a neutron; the neutron forms a neutron beam; the neutron beam defines a main axis; the retarding body slows down the neutron produced by the target to an epithermal neutron energy region; the retarding body is designed to a shape containing at least one cone; the reflecting body guides the neutron deviated from the main axis back to the main axis, so as to improve the strength of an epithermal neutron beam; the thermal neutron absorber is used for absorbing a thermal neutron, so as to prevent the thermal neutron from causing excessive dosage with a superficial normal tissue during therapy; the radiation shield is used for shielding leaked neutron and photon, so as to reduce the normal tissue dosage of a non-irradiated region.
Owner:NEUBORON MEDTECH
Neutron capture treatment system
PendingCN106975162AMeasurement with scintillation detectorsX-ray/gamma-ray/particle-irradiation therapyNuclear engineeringParticle beam
The invention provides a radiation detection system which aims to improve accuracy of neutron beam irradiation dosage of a neutron capture treatment system, and can timely discover a fault portion. The neutron capture treatment system comprises a charged particle beam, a charged particle beam inlet for pass of the charged particle beam, a neutron generation portion used for realizing nuclear reaction with the charged particle beam to generate a neutron beam, a beam shaping body used for adjusting flux and quality of the neutron beam generated by the neutron generation portion and a beam outlet adjacent to the beam shaping body, the radiation detection system comprises a radiation detection device, and the radiation detection device is used for detecting prompt Gamma rays after neutron beam irradiation in real time The invention further provides a radiation detection method which aims to improve accuracy of neutron beam irradiation dosage of the neutron capture treatment system, and can timely discover the fault portion.
Owner:NEUBORON MEDTECH
Beam diagnosis system for neutron capture therapy system
ActiveCN106552322AEasy to determineMeasurement with scintillation detectorsX-ray/gamma-ray/particle-irradiation therapyNuclear reactionIrradiation
One technical scheme of the invention provides a beam diagnosis system for a neutron capture therapy system. On one hand, the accuracy of the neutron beam irradiation dose of the neutron capture therapy system is improved, and on the other hand, the beam diagnosis system is provided for being used in the neutron capture therapy system for fault diagnosis. The neutron capture therapy system comprises a charged particle beam, a neutron generating part for generating a neutron beam through a nuclear reaction with the charged particle beam through a charged particle beam inlet of the charged particle beam, a beam shaping body for adjusting the neutron beam flux and the quality generated by the neutron generating part and a beam outlet adjacent to the beam shaping body, wherein the charged particle beam inlet is accommodated in the beam shaping body; and the neutron generating part is accommodated in the beam shaping body. The beam diagnosis system comprises a charged particle beam diagnosis device and a neutron beam diagnosis device. The beam diagnosis system is used for simultaneously diagnosing whether fault happens to the neutron capture therapy system and/or the beam diagnosis system.
Owner:NEUBORON MEDTECH
Radiant ray detection system and radiant ray detection method for neutron capture treatment system
The invention provides a radiant ray detection system capable of improving the accuracy of a neutron beam irradiation dosage in a neutron capture treatment system on one hand; the neutron capture treatment system comprises a charged particle beam, a charged particle beam inlet allowing the charged particle beam to pass, a neutron forming portion nuclearly reacting with the charged particle beam so as to form a neutron beam, a beam shaping body used for adjusting the flux and quality of the neutron beam formed by the neutron forming portion, and a beam outlet adjacent to the beam shaping body; the neutron forming portion is contained in the beam shaping body; the radiant ray detection system comprises a radiant ray detector arranged in the beam shaping body or outside the beam shaping body; the radiant ray detector is used for real time detecting an overflowing neutron beam or gamma ray formed by the neutron forming portion after nuclear reaction between the charged particle beam and the neutron forming portion. The invention also provides a radiant ray detection method capable of improving the accuracy of the neutron beam irradiation dosage in the neutron capture treatment system on the other hand.
Owner:NEUBORON MEDTECH
Beam shaping body for neutron capture therapy
The invention provides a beam shaping body for the neutron capture therapy. The beam shaping body comprises a beam inlet, a target material, a speed-retarding body adjacent to the target material, a reflector arranged to surround the outside of the speed-retarding body, a thermal neutron absorber adjacent to the speed-retarding body, a radiation shield arranged inside the beam shaping body, and a beam outlet. The nuclear reaction occurs between the target material and a proton beam that shoots into the beam inlet to generate neutrons, and the neutrons form a neutron beam which defines a main axis. The speed-retarding body slows down the neutrons generated from the target material to an epithermal neutron energy region. The speed-retarding body comprises the following materials of MgF2 and 6LiF, wherein the weight percentage of 6LiF to MgF2 is 0.1-5%. The above materials, in the form of powders or powder-pressed blanks, are subjected to powder sintering treatment by powder sintering equipment to turn into blocks. The reflector guides the neutrons deviating from the main axis back to the main axis so as to improve the intensity of an epithermal neutron beam. The thermal neutron absorber is used for absorbing thermal neutrons so as to avoid the excessive dose of the neutrons during the treatment on shallow normal tissues. The radiation shield is used for shielding leaky neutrons and photons so as to reduce the dose thereof on normal tissues in non-irradiated regions.
Owner:NEUBORON MEDTECH
Radiation detection system and method for neutron capture treatment system
PendingCN106980136AMeasurement with scintillation detectorsX-ray/gamma-ray/particle-irradiation therapyNuclear engineeringParticle beam
The invention provides a radiation detection system which aims to improve accuracy of neutron beam irradiation dosage of a neutron capture treatment system, and can timely discover a fault portion. The neutron capture treatment system comprises a charged particle beam, a charged particle beam inlet for pass of the charged particle beam, a neutron generation portion used for realizing nuclear reaction with the charged particle beam to generate a neutron beam, a beam shaping body used for adjusting flux and quality of the neutron beam generated by the neutron generation portion and a beam outlet adjacent to the beam shaping body, the radiation detection system comprises a radiation detection device, and the radiation detection device is used for detecting prompt Gamma rays after neutron beam irradiation in real time. The invention further provides a radiation detection method which aims to improve accuracy of neutron beam irradiation dosage of the neutron capture treatment system, and can timely discover the fault portion.
Owner:NEUBORON MEDTECH
Neutron capture therapy system and target material for particle line generation apparatus
PendingCN109381802AExtend your lifeIncrease beam intensityDirect voltage acceleratorsNuclear targetsCooling channelNeutron capture therapy of cancer
The invention provides a neutron capture therapy system and a target material for the neutron capture therapy system, which can enhance the heat radiation performance of the target material, reduce bubbling, and prolong the lifetime of the target material. The neutron capture therapy system comprises a neutron generation apparatus and a beam shaping body, the neutron generation apparatus comprisesan accelerator and the target material, charged particle lines generated by acceleration of the accelerator and the target material produce an effect to generate neutron lines, the target material comprises an action layer, a base layer and a heat dissipation layer, the action layer acts with the charged particle lines to generate neutron lines, the base layer supports the action layer, and the heat dissipation layer comprises a zigzag cooling channel.
Owner:NEUBORON MEDTECH
Beam shaping body used for boron neutron capture therapy
ActiveCN106955427ASimple structureEasy to assembleX-ray/gamma-ray/particle-irradiation therapyProtonRadiation shield
The invention provides a beam shaping body used for boron neutron capture therapy. The boron neutron capture therapy comprises an acceleration tube used for accelerating a proton beam. The beam shaping body comprises a beam inlet, a target material disposed in the acceleration tube, a retarder body adjacent to the target material, a reflection body disposed on the outer part of the retarder body in an encircled manner, a thermal neutron absorption body adjacent to the retarder body, a radiation shielding disposed in the beam shaping body, and a beam outlet. The beam shaping body is also provided with a cooling device. The cooling device comprises a first cooling part used for cooling the target material; a second cooling part and a third cooling part, which are extended along the axial direction of the acceleration tube, and are communicated with the first cooling part. The first cooling part is in a plane contact with the target material, and the second cooling part is used to input a cooling medium in the first cooling part, and the third cooling part is used to output the cooling medium in the first cooling part. The beam shaping body used for the boron neutron capture therapy is advantageous in that the cooling device is used for cooling the target material, and a structure is simple, and assembly is easy.
Owner:NEUBORON MEDTECH
Radiation detection system for neutron capture therapy system and detection method thereof
ActiveUS20180326225A1Improve accuracyMeasurement with scintillation detectorsNeutron sourcesNuclear reactionNeutron capture therapy of cancer
A radiation detection system and method for a neutron capture therapy system, which may increase the accuracy of neutron beam irradiation dose of the neutron capture therapy system and find out a fault position in time. The neutron capture therapy system includes a charged particle beam, a charged particle beam inlet allowing the charged particle beam to pass through, a neutron beam generating unit which may generate a neutron beam after a nuclear reaction occurs between the neutron beam generating unit and the charged particle beam, a beam shaping assembly for adjusting the flux and the quality of the neutron beam generated by the neutron beam generating unit, and a beam outlet adjacent to the beam shaping assembly, the radiation detection system includes a radiation detection device for real-time detection of γ rays instantly emitted under neutron beam irradiation.
Owner:NEUBORON MEDTECH
Neutron capture therapy system
PendingCN109464749AEfficient use ofReduce lossX-ray/gamma-ray/particle-irradiation therapyBeam directionNeutron capture therapy of cancer
The invention provides a neutron capture therapy system. The neutron capture therapy system can effectively utilize space and conduct therapy on multiple patients at the same time, does not elongate the beam transmission path excessively and thus has low loss. The neutron capture therapy system comprises an accelerator, a beam transmission assembly and neutron beam generation parts, wherein the accelerator accelerates charged particles to generate charged particle beams, the beam transmission assembly transmits the charged particle beams generated by the accelerator to the neutron beam generation part, and the neutron beam generation parts generate neuron beams for therapy and comprise a first neuron beam generation part, a second neutron beam generation part and a third neutron beam generation part; the beam transmission assembly comprises a first transmission part, a beam direction converter, a second transmission part, a third transmission part and a fourth transmission part, wherein the first transmission part is connected with the accelerator, the beam direction converter switches the heading direction of the charged particle beams, and the second transmission part, the thirdtransmission part and the fourth transmission part transmit the charged particle beams from the beam direction converter to the first neutron beam generation part, the second neutron beam generation part and the third neutron beam generation part respectively, two of the first transmission part, the third transmission part and the fourth transmission part define a first plane, the first transmission part and the second transmission part define a second plane, and the first plane is different from the second plane.
Owner:NEUBORON MEDTECH
Beam shaping body for neutron capture therapy
ActiveCN106798969ANuclear energy generationX-ray/gamma-ray/particle-irradiation therapyProtonEpithermal neutron
The invention, on one hand, provides a beam shaping body for neutron capture therapy, so as to improve the flux and the quality of a neutron source. The beam shaping body comprises a beam inlet, a target material, a retarding body adjacent to the target material, a reflector surrounding the retarding body, a thermal neutron absorber adjacent to the retarding body, a radiation shield arranged inside the beam shaping body and a beam outlet, wherein the target material and a proton beam incident from the beam inlet are subjected to a nuclear reaction to produce neutrons; the neutrons form a neutron beam; the neutron beam limits a spindle; the retarding body retards the neutrons generated from the target material to an epithermal neutron energy region; the retarding body is set to be in a shape containing at least one cone; the retarding body comprises a main body part and a supplementary part surrounding the periphery of the main body part; the material of the supplementary part is different from that of the main body part; the reflector guides neutrons deviating from the spindle back to the spindle to improve the epithermal neutron beam intensity; the thermal neutron absorber is used for absorbing thermal neutrons to avoid over dose with superficial normal tissues in the case of therapy; and the radiation shield is used for shielding leaked neutrons and photons to reduce the normal tissue dose in a non-radiation area.
Owner:NEUBORON MEDTECH
Boron neutron capture therapy system
The invention discloses a boron neutron capture therapy system, which comprises a boron neutron capture therapy device and a like [alpha]-amino acid boron trifluoride compound, wherein the structure of the like [alpha]-amino acid boron trifluoride compound is shown as formula (I) (as shown in the Description), wherein R represents hydrogen, methyl, isopropyl, 1-methyl propyl, 2-methyl propyl, hydroxymethyl, 1-hydroxyethyl, benzyl or hydroxybenzyl, and M is either H or a metal atom; and energy, which is generated after a neutron beam generated from the boron neutron capture therapy device acts on the like [alpha]-amino acid boron trifluoride compound, can damage tumor cell DNA.
Owner:NEUBORON MEDTECH
Neutron capture treatment system and target material used for particle line generating device
PendingCN108926784AImprove cooling effectExtend your lifeDirect voltage acceleratorsNuclear targetsNeutron capture therapy of cancerTreatment system
The invention provides a neutron capture treatment system and a target material used for a particle line generating device, which have the advantages that the heat dissipation property of the target material can be promoted, bubbling can be reduced, and the life of the target material is prolonged. The neutron capture treatment system provided by the invention comprises a neutron generating deviceand a beam shaping body, wherein the neutron generating device comprises an accelerator and the target material, charged particle lines generated by acceleration of the accelerator act with the target material, then neutron lines are generated, the target material comprises an action layer, a base layer and a heat dissipation layer, the action layer acts with the charged particle lines to generate neutron lines, the base layer supports the action layer, and the heat dissipation layer comprises a pipe-shaped part formed by a plurality of pipes distributed side by side.
Owner:NEUBORON MEDTECH
Beam Shapers for Neutron Capture Therapy
In order to improve the flux and the quality of a neutron source, the invention provides a beam shaping body for neutron capture therapy. The beam shaping body comprises a beam inlet, a target, a retarding body adjacent to the target, a reflecting body surrounding the external of the retarding body, a thermal neutron absorber adjacent to the retarding body, and a radiation shield and a beam outlet formed in the beam shaping body, wherein the target has nuclear reaction with proton beam entering from the beam inlet, so as to produce a neutron; the neutron forms a neutron beam; the neutron beam defines a main axis; the retarding body slows down the neutron produced by the target to an epithermal neutron energy region; the retarding body is designed to a shape containing at least one cone; the reflecting body guides the neutron deviated from the main axis back to the main axis, so as to improve the strength of an epithermal neutron beam; the thermal neutron absorber is used for absorbing a thermal neutron, so as to prevent the thermal neutron from causing excessive dosage with a superficial normal tissue during therapy; the radiation shield is used for shielding leaked neutron and photon, so as to reduce the normal tissue dosage of a non-irradiated region.
Owner:NEUBORON MEDTECH
Neutron capture therapy system
PendingCN109464750AReduced responseExempt from irradiationX-ray/gamma-ray/particle-irradiation therapyBiological activationNeutron capture therapy of cancer
The invention relates to a neutron capture therapy system. The neutron capture therapy system comprises an accelerator, a beam transmission assembly and neutron beam generation parts; the acceleratoraccelerates charged particles to generate charged particle beams, the beam transmission assembly transmits the charged particle beams generated by the accelerator to the neutron beam generation parts,the neutron beam generation parts generate neutron beams for therapy, shielding walls are arranged between the neutron beam generation parts and the accelerator so that the problems can be solved that an operation personnel is radiated by neutrons and other rays which leak from the neutron beam generation parts during maintenance of the accelerator, and the activation reaction of the acceleratoris reduced.
Owner:NEUBORON MEDTECH
Neutron capture therapy system
PendingCN109925612AAccurate irradiationX-ray/gamma-ray/particle-irradiation therapyLaser transmitterIrradiation
The present application provides a neutron capture therapy system, which includes a neutron generating unit, an irradiation chamber, a preparation chamber, and an auxiliary positioner disposed in theillumination chamber and the preparation chamber. The neutron beam generating unit includes an accelerator for accelerating the charged particle beam, a neutron beam forming portion that generates that neutron beam by reacting with the charged particle beam, and the charged particle beam between the accelerator and the neutron beam forming portion and used for transmission of the charged particlebeam, the illumination chamber is a room for irradiating an irradiated body with a neutron beam, and the preparation chamber is a room for performing preparation work required to irradiate the irradiated person with the neutron beam, the auxiliary positioner is provided with a laser emitter that emits the laser beam to position the illuminated person, and the position of the laser emitter is selectable, and the irradiated body can be positioned in any case to achieve precise illumination.
Owner:NEUBORON MEDTECH
Application of 10B-containing compound in preparation of medicine specifically combined with beta amyloid protein
InactiveCN107303299AImprove blood-brain barrier permeabilityHigh specific bindingNervous disorderEnergy modified materialsDiseaseMedicine
The invention provides application of a 10B-containing compound in preparation of a medicine specifically combined with a beta amyloid protein, wherein the medicine specifically combined with the beta amyloid protein can reduce or eliminate the beta amyloid protein in an irradiation process of a neutron beam transmitted by a neutron capture treatment device after the beta amyloid protein is combined, so that Alzheimer's disease is further treated. The invention provides a new method for treatment of the Alzheimer's disease.
Owner:NEUBORON MEDTECH
Neutron retarding material
ActiveCN106938124ARadiation/particle handlingX-ray/gamma-ray/particle-irradiation therapyLithiumTherapeutic Devices
The invention discloses a neutron retarding material composed of a lithium-containing substance and a material with a large fast neutron effect cross section and a small epithermal neutron effect cross section. The neutron retarding material is used in the beam shaper of a neutron capture therapeutic device as a retarder. The lithium-containing substance is added to a conventional neutron retarding material to improve the quality of the prosthetic beam of a neutron beam retarded by the neutron retarding material.
Owner:NEUBORON MEDTECH
Beam diagnostic systems for neutron capture therapy systems
ActiveCN106552322BEasy to determineMeasurement with scintillation detectorsX-ray/gamma-ray/particle-irradiation therapyNuclear reactionIrradiation
One technical scheme of the invention provides a beam diagnosis system for a neutron capture therapy system. On one hand, the accuracy of the neutron beam irradiation dose of the neutron capture therapy system is improved, and on the other hand, the beam diagnosis system is provided for being used in the neutron capture therapy system for fault diagnosis. The neutron capture therapy system comprises a charged particle beam, a neutron generating part for generating a neutron beam through a nuclear reaction with the charged particle beam through a charged particle beam inlet of the charged particle beam, a beam shaping body for adjusting the neutron beam flux and the quality generated by the neutron generating part and a beam outlet adjacent to the beam shaping body, wherein the charged particle beam inlet is accommodated in the beam shaping body; and the neutron generating part is accommodated in the beam shaping body. The beam diagnosis system comprises a charged particle beam diagnosis device and a neutron beam diagnosis device. The beam diagnosis system is used for simultaneously diagnosing whether fault happens to the neutron capture therapy system and / or the beam diagnosis system.
Owner:NEUBORON MEDTECH
Photon emission detection device and boron neutron capture and treatment system provided with same
PendingCN108853751AImprove detection accuracyX-ray/gamma-ray/particle-irradiation therapyPhoton emissionBoron containing
The present invention provides a boron neutron capture and treatment system. The system includes a neutron capture and treatment device, a photon emission detection device, and a treatment bed; afterneutrons are irradiated by a boron-containing (10B) drug, gamma rays can be generated; the photon emission detection device comprises a detection portion which surrounds the periphery of the treatmentbed and detects the gamma rays generated after the neutrons are irradiated by the boron-containing (10B) drug; the detection portion includes a first detecting portion and a second detecting portion;the first detecting portion and the second detecting portion can move away from or approach each other such that the detection portion forms a ring of which the radius can be increased or decreased;and the ring surrounds the treatment bed. According to the photon emission detection device of the boron neutron capture and treatment system of the invention, the radius of the ring of the detectionportion which surrounds an object to be irradiated can be changed according to an actual situation in boron neutron capture and treatment, and therefore, the detection accuracy of the photon emissiondetecting device can be improved.
Owner:NEUBORON MEDTECH
Biological dosimeter and neutron capture treatment system including same
ActiveCN109407133AHigh sensitivityGood linear relationshipDosimetersBiological material analysisMedicineNeutron capture therapy of cancer
A biological dosimeter, a method of using the same, and a neutron capture treatment system including the biological dosimeter are provided. The biological dosimeter measures a dose received by a protein in a radiation field based on the degree of degradation of the protein in the radiation field. The biological dosimeter has simple operation, few steps and a small error, and can measure the radiation dose of various radiation fields and even a mixed radiation field. The use of the biological dosimeter in the neutron capture treatment system can evaluate not only the radiation pollution in an irradiation chamber, but also a neutron dose.
Owner:NEUBORON MEDTECH
Neutron capture therapy system
The neutron capture therapy system provided by the present application includes an accelerator for generating a charged particle beam, a neutron generating portion that reacts with the charged particle beam to generate a neutron beam, and a beam shaping body. The beam shaping body includes a receiving portion, a retarding body, a reflector, a shielding device and a beam outlet, the receiving portion is provided with a vacuum tube connected with the accelerator, the vacuum tube transmits the charged particles accelerated by the accelerator to the neutron generating portion to cause the neutrongenerating portion to react with the charged particle beam to form the neutron, the neutron generating portion moves between a first position and a second position, in the first position, the neutrongenerating portion reacts with the charged particle beam to generate the neutrons, in the second position, the neutron generating portion is detached from the beam shaping body, disassembling a portion of the vacuum tube having the neutron generating portion causes the neutron generating portion to fall off from the beam shaping body, direct contact between workers and the neutron generating portion after a nuclear reaction is reduced, and the radiation safety hazards of workers is reduced.
Owner:NEUBORON MEDTECH
Neutron capture therapy system
PendingCN111686376AReduce activationReduce entryX-ray/gamma-ray/particle-irradiation therapyNuclear engineeringParticle beam
The invention provides a neutron capture therapy system. The invention aims to achieve reduction of neutrons which overflow from an irradiation chamber into an accelerator chamber. The neutron capturetreatment system comprises an accelerator, a beam shaping body, a charged particle transmission part and a shield body, wherein the accelerator is arranged in the accelerator chamber, and is used forgenerating charged particle beams, the beam shaping body is arranged in the irradiation chamber, and an accommodating part is arranged on the shielding wall of the accelerator chamber; an embedding part for embedding at least a part of the beam shaping body is arranged on the shielding wall of the irradiation chamber, neutron beams for treatment is generated through interaction of a neutron generation part in the beam shaping body with the charged particle beam, and the charged particle beam transmission part is used for transmitting the charged particle beams which are formed by the accelerator to the beam shaping body; and the charged particle beam transmission part is connected to the accelerator through the accommodating part, the charged particle beam transmission part is connected to the beam shaping body through the embedding part, and is used for transmitting the charged particle beams to the neutron generation part, and the shield body is located between the accelerator chamber and the irradiation chamber so as to reduce neutrons which are generated through interaction of the charged particle beams with the neutron generation part from entering the accelerator chamber through the accommodating part after the neutrons overflow from the embedding part.
Owner:NEUBORON THERAPY SYST LTD
Neutron capture therapy system
The neutron capture therapy system provided by the present application includes an accelerator for generating a charged particle beam, a neutron generating portion that reacts with the charged particle beam to generate a neutron beam, and a beam shaping body. The beam shaping body includes a receiving portion, a retarding body, a reflector, a shielding device and a beam outlet, the receiving portion is provided with a vacuum tube connected to the accelerator, and the neutron generating portion is disposed at an end of the vacuum tube, the vacuum tube transmits the charged particles acceleratedby the accelerator to the neutron generating portion to cause the neutron generating portion to react with the charged particle beam to form the neutron beam, the neutron generating portion moves between a first position and a second position, in the first position, the neutron generating portion reacts with the charged particle beam to generate neutrons, in the second position, the neutron generating portion is detached from the beam shaping body, and the beam shaping body and the shielding device keep the neutron generating portion in the shielding through movement from the first position to the second position to prevent that the radiation leaked from the neutron generating portion is exposed to the worker.
Owner:NEUBORON MEDTECH
Beam shaping body for neutron capturing treatment
The invention provides a beam shaping body which can be used in a neutron capturing system to change the irradiation range of neutron beams. The beam shaping body comprises a beam inlet, a target material, a deceleration body adjacent to the material body, a reflector surrounding the outside of the deceleration body, a thermal neutron absorber adjacent to the deceleration body, a radiation shieldarranged in the beam shaping body and a beam outlet. The target material makes nuclear reaction with a proton beam input via the beam inlet to generate neutrons, the neutrons form a neutron beam, theneutron beam limits one main axis, the deceleration body decelerates the neutrons generated from the target material to an epithermal neutron energy zone, the reflector guides neutrons deviated from the main axis back to the main axis to gather epithermal neutrons, the thermal neutron absorber absorbs thermal neutrons to avoid excessive dosage in normal superficial tissues during treatment, the radiation shield shields leaked neutrons and photons to reduce the normal tissue dosage in a non-irradiation area, and the beam shaping body further comprises a replacement member which can be mounted or dismounted in/from the shaping body to change the irradiation range of the neutron beam.
Owner:NEUBORON MEDTECH
Neutron capture therapy system and target material for particle line generation apparatus
PendingCN108926781AExtend your lifeEasy to shapeX-ray/gamma-ray/particle-irradiation therapyCooling channelAdditive layer manufacturing
The invention provides a neutron capture therapy system and a target material for a particle line generation apparatus, which can enhance the heat radiation performance of the target material, prolongthe lifetime of the target material, and facilitate molding. The neutron capture therapy system comprises a neutron generation apparatus and a beam shaping body, the neutron generation apparatus comprises an accelerator and the target material, charged particle lines generated by acceleration of the accelerator and the target material produce an effect to generate neutron lines, the target material comprises an effect layer, a pedestal layer and a heat radiation layer, the effect layer and the charged particle lines produce an effect to generate the neutron lines, the pedestal layer supportsthe effect layer, the heat radiation layer comprises a cooling channel allowing circulation of a cooling medium, and the cooling channel is formed by additive manufacturing.
Owner:NEUBORON MEDTECH
NEUTRON CAPTURE THERAPY SYSTEM FOR ELIMINATING AMYLOID Beta-PROTEIN DEPOSITION PLAQUE
InactiveUS20190022222A1Reduce or eliminate amyloid β-protein deposition plaqueAvoid excessNervous disorderEnergy modified materialsMedicineAmyloid beta
The present disclosure provides a neutron capture therapy system for eliminating amyloid β-protein deposition plaque, comprising a neutron capture therapy device and a 10B-containing compound capable of specifically binding to amyloid β-protein deposition plaque, and the energy generated when the neutron beam generated by the neutron capture therapy device irradiates on the 10B element can destroy the structure of the amyloid β-protein deposition plaque. The beneficial effects of the present disclosure are targeted and highly effective destruction of amyloid β-protein deposition plaque.
Owner:NEUBORON MEDTECH
Neutron capture therapy system
ActiveCN106474633AEasy to replaceSimple structureX-ray/gamma-ray/particle-irradiation therapyEpithermal neutronProton
The application provides a neutron capture therapy system comprising a beam shaping body. The beam shaping body comprises a beam entrance, a neutron production part arranged inside the beam shaping body, a retarding body adjacent to the neutron generation part, a reflecting body surrounding the retarding body, and a beam exit. Neutrons are produced through nuclear reaction of the neutron production part with proton beams going into the beam entrance. The retarding body retards the neutrons produced by the neutron production part. The reflecting body guides the deviated neutrons to the retarding body to improve the strength of epithermal neutron beams. The beam shaping body comprises at least one moving part capable of moving toward or away from the neutron production part. The at least one moving part has a first position and a second position, and moves between the first position and the second position. When the at least one moving part is in the first position, the neutron production part can be replaced; and when the at least one moving part is in the second position, the neutron production part cannot be replaced. The neutron production part is easy to replace. The neutron capture therapy system has a simple structure, and is flexible to use.
Owner:NEUBORON MEDTECH
Neutron capture treatment system
PendingCN111714786AMeet assembly tolerancesIncrease beam intensityShieldingNeutron sourcesNuclear engineeringNeutron capture therapy of cancer
The invention provides a neutron capture treatment system. The neutron capture treatment system comprises a neutron generation device and a beam shaping body, and further comprises a concrete wall which forms a space for accommodating the neutron generation device and the beam shaping body and shields radiation generated by the neutron generation device and the beam shaping body, wherein a supporting module is arranged in the concrete wall; the supporting module can support the beam shaping body and is used for adjusting the position of the beam shaping body; and the supporting module comprises concrete and a reinforcing part at least partially arranged in the concrete. According to the neutron capture treatment system, a locally adjustable support is designed for the beam shaping body, sothat the beam shaping body meets the precision requirement, the beam quality is improved, and the assembly tolerance of a target is met.
Owner:NEUBORON THERAPY SYST LTD
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