Micro-nano bioactive glass micro-sphere with high calcium and phosphorus content and preparation method of micro-sphere

A technology of bioactive glass and phosphorus content, applied in the field of biomedical materials, can solve the problems of destroying the silicon-oxygen network, unable to obtain dispersive micro-nano bioactive glass, etc., and achieve uniform particle size, excellent biomineralization activity, and good dispersion. sexual effect

Active Publication Date: 2019-03-08
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, too high calcium and phosphorus addition will destroy the silicon-oxygen network of the micro-nano bioactive glass, and the micro-nano bioactive glass with regular shape and good dispersion cannot be obtained, and reducing the addition of calcium and phosphorus will affect its biomineralization. function, limiting its application

Method used

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  • Micro-nano bioactive glass micro-sphere with high calcium and phosphorus content and preparation method of micro-sphere
  • Micro-nano bioactive glass micro-sphere with high calcium and phosphorus content and preparation method of micro-sphere
  • Micro-nano bioactive glass micro-sphere with high calcium and phosphorus content and preparation method of micro-sphere

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] A method for increasing the content of calcium and phosphorus in bioactive glass, the operation steps are as follows:

[0039] (1) Add 12g of cetyltrimethylammonium bromide and 0.36mL of triethanolamine to 108mL of deionized water in sequence, and stir at 60°C for 1 hour to completely dissolve them to form an aqueous phase solution.

[0040] (2) Add 12mL tetraethyl orthosilicate to 48mL cyclohexane, mix well to form an oil phase solution.

[0041] (3) Add the oil phase solution to the water phase solution dropwise to form a two-phase separation system with upper and lower layers. Stir the lower water phase at a stirring rate of 100 rpm at 60°C. After reacting for 3 hours, add 0.921 mL of triethyl phosphate, The reaction was continued for 9h to obtain a gel solution.

[0042] (4) Centrifuge the gel solution obtained in step (3), wash to obtain a wet gel precipitate, and then place the wet gel in a lyophilizer to freeze-dry for 2 days to obtain a gel powder.

[0043] (5...

Embodiment 2

[0046] A method for increasing the content of calcium and phosphorus in bioactive glass, the operation steps are as follows:

[0047] (1) Add 12g of cetyltrimethylammonium bromide and 0.36mL of triethanolamine to 108mL of deionized water in sequence, and stir at 60°C for 1 hour to completely dissolve them to form an aqueous phase solution.

[0048] (2) Add 12mL tetraethyl orthosilicate to 48mL cyclohexane, mix well to form an oil phase solution.

[0049] (3) Add the oil phase solution to the water phase solution dropwise to form a two-phase separation system with upper and lower layers. Stir the lower water phase at a stirring rate of 150 rpm at 65°C. After reacting for 2.5 hours, add 0.921 mL of triethyl phosphate , and continued to react for 9.5h to obtain a gel solution.

[0050] (4) Centrifuge the gel solution obtained in step (3), wash to obtain a wet gel precipitate, and then place the wet gel in a lyophilizer to freeze-dry for 2 days to obtain a gel powder.

[0051] (...

Embodiment 3

[0054] A method for increasing the content of calcium and phosphorus in bioactive glass, the operation steps are as follows:

[0055] (1) Add 12g of cetyltrimethylammonium bromide and 0.36mL of triethanolamine to 108mL of deionized water in sequence, and stir at 60°C for 1 hour to completely dissolve them to form an aqueous phase solution.

[0056] (2) Add 12mL tetraethyl orthosilicate to 48mL cyclohexane, mix well to form an oil phase solution.

[0057] (3) Add the oil phase solution to the water phase solution dropwise to form a two-phase separation system with upper and lower layers. Stir the lower water phase at a stirring rate of 150 rpm at 60°C. After reacting for 3 hours, add 1.223 mL of triethyl phosphate, The reaction was continued for 9h to obtain a gel solution.

[0058] (4) Centrifuge the gel solution obtained in step (3), wash to obtain a wet gel precipitate, and then place the wet gel in a lyophilizer to freeze-dry for 2 days to obtain a gel powder.

[0059] (5) ...

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Abstract

The invention discloses a micro-nano bioactive glass micro-sphere with high calcium and phosphorus content and a preparation method of the micro-sphere. The method includes the steps: (1) adding surfactants and catalysts into water to obtain water solution, and mixing ethyl orthosilicate and organic solvents into oil solution; (2) dropping the oil solution into the water solution, stirring lower water solution, adding triethyl phosphate after heating reaction and continuing heating reaction to obtain gel solution; (3) centrifugally separating the gel solution, and cleaning and then drying thegel solution to obtain gel powder; (4) adding calcium nitrate tetrahydrate into absolute ethyl alcohol, adding the dried gel powder into calcium nitrate ethanol solution and uniformly mixing the gel powder and the ethanol solution; (5) volatilizing ethanol to obtain bioactive glass gel powder and then performing heat treatment to obtain the micro-nano bioactive glass micro-sphere. The micro-nano bioactive glass micro-sphere prepared by the method has good dispersity and high calcium and phosphorus content, and is a novel bone and tooth repair material.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to a micronano bioactive glass microsphere with high calcium and phosphorus content and a preparation method thereof. Background technique [0002] Bioactive glass (BG) is a kind of calcium phosphosilicate biomedical material prepared by Professor Hench through the melting method in the early 1970s. Due to its good biocompatibility and biomineralization function, it can be applied in orthopedics and dentistry. However, the energy consumption required for the preparation by the melting method is high, and the high-temperature reaction at 1400 °C will easily lead to doping of the material with impurity ions, and the material is relatively dense and has a small specific surface area, which is not conducive to the release of ions and the degradation of the material. [0003] Micro-nano bioactive glass (MNBG) is a new type of bioactive glass material prepared by sol-gel method combin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C03C12/00
CPCC03C12/00
Inventor 陈晓峰陈雪颖田婷莫云飞
Owner SOUTH CHINA UNIV OF TECH
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