A kind of micronano bioactive glass microsphere with high calcium phosphorus content and preparation method thereof

A technology of bioactive glass and phosphorus content, applied in the field of biomedical materials, can solve the problems of destroying the silicon-oxygen network, unable to obtain dispersive micro-nano bioactive glass, etc., achieving uniform particle size, excellent biomineralization activity, and solving calcium low content effect

Active Publication Date: 2021-10-26
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, too high calcium and phosphorus addition will destroy the silicon-oxygen network of the micro-nano bioactive glass, and the micro-nano bioactive glass with regular shape and good dispersion cannot be obtained, and reducing the addition of calcium and phosphorus will affect its biomineralization. function, limiting its application

Method used

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  • A kind of micronano bioactive glass microsphere with high calcium phosphorus content and preparation method thereof
  • A kind of micronano bioactive glass microsphere with high calcium phosphorus content and preparation method thereof
  • A kind of micronano bioactive glass microsphere with high calcium phosphorus content and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] A method for increasing the content of calcium and phosphorus in bioactive glass, the operation steps are as follows:

[0039] (1) Add 12g of cetyltrimethylammonium bromide and 0.36mL of triethanolamine to 108mL of deionized water in sequence, and stir at 60°C for 1 hour to completely dissolve them to form an aqueous phase solution.

[0040] (2) Add 12mL tetraethyl orthosilicate to 48mL cyclohexane, mix well to form an oil phase solution.

[0041] (3) Add the oil phase solution to the water phase solution dropwise to form a two-phase separation system with upper and lower layers. Stir the lower water phase at a stirring rate of 100 rpm at 60°C. After reacting for 3 hours, add 0.921 mL of triethyl phosphate, The reaction was continued for 9h to obtain a gel solution.

[0042] (4) Centrifuge the gel solution obtained in step (3), wash to obtain a wet gel precipitate, and then place the wet gel in a lyophilizer to freeze-dry for 2 days to obtain a gel powder.

[0043] (5...

Embodiment 2

[0046] A method for increasing the content of calcium and phosphorus in bioactive glass, the operation steps are as follows:

[0047] (1) Add 12g of cetyltrimethylammonium bromide and 0.36mL of triethanolamine to 108mL of deionized water in sequence, and stir at 60°C for 1 hour to completely dissolve them to form an aqueous phase solution.

[0048] (2) Add 12mL tetraethyl orthosilicate to 48mL cyclohexane, mix well to form an oil phase solution.

[0049] (3) Add the oil phase solution to the water phase solution dropwise to form a two-phase separation system with upper and lower layers. Stir the lower water phase at a stirring rate of 150 rpm at 65°C. After reacting for 2.5 hours, add 0.921 mL of triethyl phosphate , and continued to react for 9.5h to obtain a gel solution.

[0050] (4) Centrifuge the gel solution obtained in step (3), wash to obtain a wet gel precipitate, and then place the wet gel in a lyophilizer to freeze-dry for 2 days to obtain a gel powder.

[0051] (...

Embodiment 3

[0054] A method for increasing the content of calcium and phosphorus in bioactive glass, the operation steps are as follows:

[0055] (1) Add 12g of cetyltrimethylammonium bromide and 0.36mL of triethanolamine to 108mL of deionized water in sequence, and stir at 60°C for 1 hour to completely dissolve them to form an aqueous phase solution.

[0056] (2) Add 12mL tetraethyl orthosilicate to 48mL cyclohexane, mix well to form an oil phase solution.

[0057] (3) Add the oil phase solution to the water phase solution dropwise to form a two-phase separation system with upper and lower layers. Stir the lower water phase at a stirring rate of 150 rpm at 60°C. After reacting for 3 hours, add 1.223 mL of triethyl phosphate, The reaction was continued for 9h to obtain a gel solution.

[0058] (4) Centrifuge the gel solution obtained in step (3), wash to obtain a wet gel precipitate, and then place the wet gel in a lyophilizer to freeze-dry for 2 days to obtain a gel powder.

[0059] (5) ...

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Abstract

The invention discloses a micronano bioactive glass microsphere with high calcium and phosphorus content and a preparation method thereof. The method comprises the following steps: (1) adding a surfactant and a catalyst into water to obtain a water phase solution; mixing tetraethyl orthosilicate and an organic solvent to form an oil phase solution; (2) adding the oil phase solution dropwise to the water phase solution , then stir the lower aqueous phase solution, add triethyl phosphate after heating and reacting, continue heating and reacting to obtain a gel solution; (3) centrifuge the gel solution, wash and dry to obtain a gel powder; (4) Calcium nitrate tetrahydrate is added to absolute ethanol, then the dried gel powder is added to the ethanol solution of calcium nitrate, and mixed evenly; (5) The ethanol is volatilized to obtain bioactive glass gel powder, and then heat-treated to obtain micro Nano bioactive glass microspheres. The micronano biologically active glass microspheres prepared by the method have good dispersibility and high calcium and phosphorus content, and are a new type of bone and tooth restoration material.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to a micronano bioactive glass microsphere with high calcium and phosphorus content and a preparation method thereof. Background technique [0002] Bioactive glass (BG) is a kind of calcium phosphosilicate biomedical material prepared by Professor Hench through the melting method in the early 1970s. Due to its good biocompatibility and biomineralization function, it can be applied in orthopedics and dentistry. However, the energy consumption required for the preparation by the melting method is high, and the high-temperature reaction at 1400 °C will easily lead to doping of the material with impurity ions, and the material is relatively dense and has a small specific surface area, which is not conducive to the release of ions and the degradation of the material. [0003] Micro-nano bioactive glass (MNBG) is a new type of bioactive glass material prepared by sol-gel method combin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C03C12/00
CPCC03C12/00
Inventor 陈晓峰陈雪颖田婷莫云飞
Owner SOUTH CHINA UNIV OF TECH
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