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Pickering emulsion and drug-loaded emulsion with temperature-controlled release behavior and preparation method

An emulsion and drug-carrying technology, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, can solve problems such as high cost, damage to biological cells, and stimulation of biological tissues. Mild reaction conditions, easy particle recovery, and short reaction time

Active Publication Date: 2022-04-29
NORTHWESTERN POLYTECHNICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the use of surfactants as emulsion stabilizers is not only costly but also difficult to recover surfactants; in addition, some amphiphilic polymers can also stimulate biological tissues and even damage biological cells, which limits their application in the field of biomedicine. application

Method used

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  • Pickering emulsion and drug-loaded emulsion with temperature-controlled release behavior and preparation method
  • Pickering emulsion and drug-loaded emulsion with temperature-controlled release behavior and preparation method
  • Pickering emulsion and drug-loaded emulsion with temperature-controlled release behavior and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] Weigh 25 mg of SiO 2 @short-PNIPAm-I particles, disperse them in 5mL deionized water, place them in an ultrasonic cleaner for about 5min in an ice-water bath until the particles are evenly dispersed, then add 5mL isopropyl myristate as the oil phase, Stir with a homogeneous stirrer for 5min (18000r / min) under the condition of ice-water bath. That is, the obtained W / O type Pickering emulsion.

Embodiment 2

[0066] Weigh 25 mg of SiO 2@short-PNIPAm-II particles, disperse them in 5mL deionized water, place them in an ultrasonic cleaner for about 5min in an ice-water bath until the particles are evenly dispersed, then add 6mL isopropyl myristate as the oil phase, Stir with a homogeneous stirrer for 5min (16000r / min) under the condition of ice-water bath. That is, the obtained W / O Pickering emulsion.

Embodiment 3

[0068] Weigh 25 mg of SiO 2 @medium-PNIPAm particles, disperse them in 5mL deionized water, place them in an ultrasonic cleaner for about 5min in an ice-water bath until the particles are uniformly dispersed, add 5mL trichlorethylene as the oil phase, and use them in an ice-water bath Stir with a homogeneous mixer for 5min (18000r / min). That is, the obtained O / W type Pickering emulsion.

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Abstract

The invention relates to a Pickering emulsion and a drug-loaded emulsion with temperature-controlled release behavior and a preparation method, utilizing SiO with different grafting ratios 2 @PNIPAm particles are particle stabilizers, W / O or O / W type Pickering emulsions are prepared respectively, and O / W type emulsions with different temperature responses are used as drug carriers to construct a series of Pickering emulsions with different temperature release behaviors . Raw materials such as monomers and solvents used in the present invention can be produced industrially, the experimental reaction time is short, the reaction conditions are mild, and the change of the chemical composition is not affected while taking into account the operability, and it is suitable for a system with multiple repeated cycles, particle recovery easy. In addition to the field of biomedicine, it also has important application value in fields that require demulsification under specific conditions, such as crude oil extraction, cosmetics, microreactors, etc.

Description

technical field [0001] The invention belongs to the field of responsive emulsion and drug sustained release, relates to a Pickering emulsion and a drug-loaded emulsion with temperature-controlled release behavior and a preparation method, in particular to the use of SiO with different grafting ratios 2 @PNIPAm particles are particle stabilizers, W / O or O / W type Pickering emulsions are prepared respectively, and O / W type emulsions with different temperature responses are used as drug carriers to construct a series of Pickering emulsions with different temperature release behaviors . Background technique [0002] Emulsions play an important role in many industrial processes and commercial products where mutually immiscible liquids coexist. Traditional emulsions generally use surfactants and amphiphilic polymers as emulsion stabilizers. Surfactants and amphiphilic polymers can Adsorbed at the oil / water interface, relying on electrostatic interaction and steric repulsion to hin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/107A61K47/04A61K47/18A61K9/51A61K31/616A61K31/07A61K31/192
CPCA61K47/02A61K47/18A61K9/1075A61K9/5115A61K9/5123A61K31/07A61K31/192A61K31/616
Inventor 陈芳殷玮达董晨翟薇马晓燕
Owner NORTHWESTERN POLYTECHNICAL UNIV
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