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Composition and preparation process for improving body functions of pregnant women, breastfeeding mothers and fetuses

A technology of composition and breastfeeding, which is applied in the direction of drug combination, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., and can solve the problems of low absorption of hemin chloride and high iron loss

Active Publication Date: 2020-08-14
江西天元药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

3. Excessive iron loss: chronic long-term iron loss without correction can cause IDA
However, the effectiveness of existing hemin preparations is still somewhat improved, especially since the absorption amount of hemin is still low

Method used

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  • Composition and preparation process for improving body functions of pregnant women, breastfeeding mothers and fetuses

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073] Embodiment 1: preparation composition

[0074] Prescription: hemin: 100 parts by weight,

[0075] Thinner (starch): 300 parts by weight,

[0076] Phospholipid (soybean): 7.5 parts by weight.

[0077] Preparation method: crush hemin in advance to a fine powder that can pass through a 100-mesh sieve; make phospholipids dissolved in ethanol to make a 22% solution; fluidized equipment (fluidized bed granulation) at 33°C Spray the phospholipid solution into the hemin fine powder in the fluidized state in the machine), continue to fluidize to remove ethanol; add 25 parts by weight of diluent and mix evenly, and press the material into a sheet with an extruder; The flakes were frozen at -18°C for 28 hours; the flakes were crushed, mixed with the remaining amount of diluent, and then crushed to a fine powder that could pass through a 60-mesh sieve to obtain the composition;

[0078] Further, half of the amount of the composition in fine powder form is made into a formulatio...

Embodiment 2

[0079] Embodiment 2: preparation composition

[0080] Prescription: hemin: 100 parts by weight,

[0081] Thinner (sucrose): 50 parts by weight,

[0082] Phospholipid (soybean): 25 parts by weight.

[0083] Preparation method: crush hemin in advance to fine powder that can pass through a 100-mesh sieve; make phospholipids dissolved in ethanol to make a 20% solution; fluidized equipment (fluidized bed granulation) at 35°C Spray the phospholipid solution into the hemin fine powder in a fluidized state in the machine), and continue to fluidize to remove ethanol; add 30 parts by weight of diluent and mix evenly, and press the material into a sheet with an extruder; The flakes were frozen at -20°C for 24 hours; the flakes were crushed, mixed with the remaining amount of diluent, and then crushed to a fine powder that could pass through a 60-mesh sieve to obtain the composition;

[0084] Further, half the amount of the composition in fine powder form is made into a preparation f...

Embodiment 3

[0085] Embodiment 3: preparation composition

[0086] Prescription: hemin: 100 parts by weight,

[0087] Diluent (lactose): 1200 parts by weight,

[0088] Phospholipid (soybean): 1 part by weight.

[0089] Preparation method: crush hemin in advance to a fine powder that can pass through a 100-mesh sieve; dissolve phospholipids in ethanol to make a 25% solution; fluidized equipment (fluidized bed granulation) at 30 ° C Spray the phospholipid solution into the hemin fine powder in the fluidized state in the machine), continue to fluidize to remove ethanol; add 20 parts by weight of diluent and mix evenly, and press the material into flakes with an extruder; Freeze the flakes at -15°C for 30 hours; crush the flakes, add the remaining amount of diluent, mix evenly, and continue crushing to a fine powder that can pass through a 60-mesh sieve to obtain the composition;

[0090] Further, half of the amount of the fine powder composition is made into a formulation (soft capsule)....

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PUM

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Abstract

The invention relates to a composition for improving body functions of fetuses of pregnant women, puerperae and wet nurses and a preparation process, in particular to a pharmaceutical composition which comprises chlorinated ferriheme and a diluent. The diluent is selected from starch, cane sugar, lactose, microcrystalline cellulose and calcium hydrogen phosphate. The invention also relates to thepreparation process of the composition for improving body functions of fetuses of pregnant women, puerperae and wet nurses as well as an application of the composition in preparing a drug for improving body functions of fetuses of pregnant women, puerperae and wet nurses. The composition provided by the invention shows an excellent biological effect.

Description

technical field [0001] The invention relates to a composition and a preparation process for improving body functions of pregnant women and lactating mothers and fetuses. Specifically, the present invention relates to a composition for improving body functions of pregnant women and lactating mothers and fetuses made of hemin chloride as an active ingredient. In particular, the composition of the present invention for improving body functions of pregnant women, breastfeeding mothers and fetuses exhibits excellent biological effects. Background technique [0002] When the body's iron demand and supply are out of balance, it leads to depletion of iron stores in the body (ID), followed by iron deficiency in red blood cells (IDE), and finally causes iron deficiency anemia (IDA). IDA is the final stage of iron deficiency (including ID, IDE, and IDA), manifested as microcytic hypochromic anemia and other abnormalities caused by iron deficiency. IDA is the most common anemia. Its i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/555A61K33/26A61K47/24A61P9/10A61P7/06A61P39/06A61P37/04A61P15/00
CPCA61K31/555A61K33/26A61K47/24A61P7/06A61P9/10A61P15/00A61P37/04A61P39/06
Inventor 傅金荣付金洪
Owner 江西天元药业有限公司