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Method for determination of methamphetamine and ecstasy in human hair by flash evaporation-gas chromatography-mass spectrometry

A gas chromatography mass spectrometry and ecstasy technology, which is applied in the field of determination of methamphetamine and ecstasy in human hair, can solve problems such as time-consuming, large hair consumption, organic solvent consumption, etc., so as to reduce the difficulty of sampling, simplify experimental steps, and save analysis time. Effect

Active Publication Date: 2021-02-02
ZHEJIANG UNIV OF TECH
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  • Application Information

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Problems solved by technology

The sample pretreatment steps of this method are complex, time-consuming, and consume a large amount of organic solvents. At the same time, a large amount of hair is consumed for one treatment.
It is reported in the literature that ultra-high performance liquid chromatography-tandem mass spectrometry is used to analyze MAMP in hair, but sample pretreatment methods such as extraction, concentration, and derivatization are still required. At the same time, the equipment used is relatively expensive, which is not conducive to the popularization of the method and to promote

Method used

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  • Method for determination of methamphetamine and ecstasy in human hair by flash evaporation-gas chromatography-mass spectrometry
  • Method for determination of methamphetamine and ecstasy in human hair by flash evaporation-gas chromatography-mass spectrometry
  • Method for determination of methamphetamine and ecstasy in human hair by flash evaporation-gas chromatography-mass spectrometry

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Experimental program
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Effect test

Embodiment 1

[0031] The investigation of embodiment 1 MAMP and MDMA thermostability

[0032] The chromatographic responses of MAMP and MDMA standard solutions were investigated at 250°C, 300°C, 350°C, 400°C and 450°C in the cracking furnace respectively. The chromatographic response gradually decreases.

Embodiment 2

[0033] The selection of embodiment 2 cracking furnace temperature

[0034] The chromatographic response of MAMP in positive hair samples was investigated at 250°C, 300°C, 350°C, 400°C and 450°C in the pyrolysis furnace, and it was found that the chromatographic response of MAMP was the highest at 350°C. Therefore, the temperature of the pyrolysis furnace was chosen to be 350°C for analysis.

Embodiment 3

[0035] Qualitative and quantitative ion selection of embodiment 3 MAMP and MDMA

[0036] Take 1 μL of the standard solution with a concentration of 150 mg / L of MAMP and MDMA, and put it in a sample cup. Put the sample cup containing the sample into the cracker, place the cracker at the inlet of the gas chromatograph mass spectrometer, inject the sample when the temperature of the cracking furnace reaches 350°C, and use the gas chromatograph mass spectrometer for online detection to obtain MAMP and MDMA mass spectrum. MAMP selects m / z 58, 65 and 91 with the highest response as qualitative ions, among which m / z 58 is used as quantitative ion; MDMA selects m / z 58, 77 and 135 with the highest response as qualitative ions, among which m / z 58 is Quantitative ions.

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Abstract

The invention provides a method for determining the content of methamphetamine and ecstasy in human hair by using flash-gas chromatography mass spectrometry. Compared with the prior art, the present invention does not need complicated sample pretreatment process, and the developed flash gas chromatography mass spectrometry The method is easy to operate and environmentally friendly, and can effectively save analysis time and simplify experimental steps. The amount of sample consumed by the present invention is small, and only one hair (0.3 mg) is needed for one treatment, which can greatly reduce the difficulty of sampling. The method developed by the present invention is applicable It is used to analyze the content of MAMP and MDMA in human hair, and has far-reaching significance for the monitoring of drug abuse and drug abuse.

Description

technical field [0001] The invention relates to a method for determining the content of methamphetamine and ecstasy in human hair, in particular to a method for determining the content of methamphetamine and ecstasy in human hair by flash evaporation-gas chromatography mass spectrometry. Background technique [0002] Methamphetamine, a new type of drug, is mainly composed of methamphetamine (MAMP), also known as methamphetamine and methamphetamine. It is an odorless or slightly bitter transparent crystal. The pure product is very similar to rock sugar. Shaped like ice, it is commonly known as methamphetamine. Smokers and drug dealers also call it "ice". Ecstasy, a kind of synthetic drug, in which 3,4-methylenedioxymethamphetamine (MDMA) is one of the main active ingredients. After drug addicts take ecstasy, the cerebral cortex is excited. When there is no music, the head will shake slightly, and there will be a feeling of fatigue and drowsiness. But when the users are sti...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/88G01N30/12
CPCG01N30/12G01N30/88G01N2030/126G01N2030/8813
Inventor 黄忠平刘颜姝娴王丽丽刘会君范一雷
Owner ZHEJIANG UNIV OF TECH
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