Preparation method for high-transparency bionic blood vessel model for hydrodynamics observation experiment

Abstract

The invention discloses a preparation method for a high-transparency bionic blood vessel model for a hydrodynamics observation experiment, and belongs to the technical field of medical models. The preparation method comprises the following steps that a bionic blood vessel three-dimensional computer model is created by using a medical imaging system software; a male die of the bionic blood vessel model is manufactured by using an FDM 3D printing technology; a mixed liquor of PDMS and curing agent is proportioned; layered casting is carried out on the male die of the blood vessel model by usinga PDMS solution; after the PDMS is cured, a reserved inlet and outlet of the model is cut open to dissolve the male die of the blood vessel model; a completed PDMS mold is post-processed, thereby improving the surface precision, that is, the high-transparency bionic blood vessel model can be obtained. The preparation method for the high-transparency bionic blood vessel model for the hydrodynamicsobservation experiment has the advantages that the bionic blood vessel model has high transparency, high surface precision, high bionic performance and good wall surface elasticity, the preparation method is simple, forming is easy, and the development of the hydrodynamics observation experiment and medical teaching demonstration is facilitated.

Description

technical field [0001] The invention relates to a method for preparing a highly transparent bionic blood vessel model used in fluid mechanics observation experiments, and belongs to the technical field of medical models. Background technique [0002] Cardiovascular diseases are the leading cause of morbidity and mortality worldwide. Hemodynamics has been an important part of the study of the cardiovascular system and cardiovascular diseases for the past three decades. A large number of studies are limited to the use of computational fluid dynamics (Computational fluiddynamic) modeling for blood flow simulation, while the in vitro flow observation experiments of the cardiovascular system often use particle image velocimetry (Particle Image Velocimetry), which requires the experimental model to have a high Transparency and high surface precision. [0003] At present, the experimental model of personalized bionic blood vessels in vitro is mainly three-dimensionally reconstruc...

AI Technical Summary

Problems solved by technology

For example, printing with materials such as ABS / PLA requires organic solvents (acetone, dichloromethane, etc.) to dissolve, and the dissolution rate is slow, and the process is chemically polluted and toxic; low-temperature materials such as Wood’s metal and paraffin are used for printing, which is easy to leave On the surface of commonly used silicone molds (Polydimethylsiloxane, Polydimethylsiloxane), resulting in insufficient transparency, which is not conducive to experimental observation of internal blood flow

Therefore, how to make a highly transparent bionic blood vessel model is a major problem in the in vitro experimental measurement of biofluids, which greatly limits the development and application of biofluids technology.

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