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Pharmaceutical composition with selective killing or nM level efficient killing effect on drug-resistant tumors and application of pharmaceutical composition

A composition and selective technology, applied in the field of tumor treatment, can solve the problem that the selective killing effect of drug-resistant tumor cells has not been reported.

Inactive Publication Date: 2019-03-29
INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no report on the growth inhibitory effect of the active parts of custard apple on the nM level of drug-resistant tumor cells, and there is no report on the selective killing effect of cherimoya extracts, effective parts, and monomeric compounds on drug-resistant tumor cells.

Method used

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  • Pharmaceutical composition with selective killing or nM level efficient killing effect on drug-resistant tumors and application of pharmaceutical composition
  • Pharmaceutical composition with selective killing or nM level efficient killing effect on drug-resistant tumors and application of pharmaceutical composition
  • Pharmaceutical composition with selective killing or nM level efficient killing effect on drug-resistant tumors and application of pharmaceutical composition

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preparation example Construction

[0038] The preparation method of the custard apple seed extract of the present invention preferably comprises the following steps:

[0039] (1) pulverizing the custard apple seeds to obtain granules;

[0040] (2) mixing the particulate matter with a degreasing solvent, and separating the solid and liquid after degreasing to obtain a filter residue;

[0041] (3) mixing the filter residue with the extraction solvent, separating the solid and liquid after extraction to obtain a liquid phase;

[0042] (4) removing the solvent in the liquid phase to obtain the custard apple seed extract.

[0043] In the present invention, when preparing the custard apple seed extract, the custard apple seeds are pulverized to obtain granules, and the particle diameter of the granules is preferably 2-25 meshes, more preferably 10-18 meshes. The types of custard apple seeds in the present invention include but not limited to custard apple, custard apple or soursop.

[0044] In the present inventio...

Embodiment 1

[0067] Sweet Apple, Ethanol Ultrasonic Extraction (Round-Ethanol Ultrasonic Extraction)

[0068] Take 20g of dried custard apple seeds, crush them into 10-18 mesh particles, add n-hexane to soak and degrease twice (use 200mL of n-hexane each time, shake intermittently, time 5h), filter with filter paper, add 200mL of absolute ethanol to the filter residue , 25°C and 250W ultrasonic extraction twice, each time 30min, filter paper suction filtration, combined two filtrates, 55°C heating and rotary evaporation under reduced pressure to remove the organic solvent, vacuum drying to obtain the ethanol ultrasonic extract.

Embodiment 2

[0070] Annus apple, ultrasonically extracted with ethanol (soil-alcohol ultrasonically extracted)

[0071] Take 20g of dried custard apple seeds, crush them into 10-18 mesh particles, add n-hexane to soak and degrease twice (use 200mL of n-hexane each time, shake intermittently, for 5h), filter with filter paper, add 200mL of absolute ethanol to the filter residue, Ultrasonic extraction at 25°C and 250W twice, 30min each time, suction filtration with filter paper, combined two filtrates, heating under reduced pressure at 55°C and rotary evaporation to remove the organic solvent, and vacuum drying to obtain the ethanol ultrasonic extract.

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Abstract

The invention provides pharmaceutical composition with a selective killing or nM level efficient killing effect on drug-resistant tumors and an application of the pharmaceutical composition, and relates to the technical field of tumor therapy. The pharmaceutical composition is prepared from effective component as follows: annona squamosal seed extract, and the annona squamosal seed extract form further comprises an ACGs (annonaceous acetogenins) effective part of or an ACGs monomer. The effective components in the composition have the moderate-intensity killing effect on tumor cells, but havethe selective killing or nM level efficient killing effect on the drug-resistant tumors; after nanoparticles are prepared from the pharmaceutical composition, not only are the problems of insolubilityand difficulty in administration of total lactone solved, but also a strong killing effect of ACGs on the drug-resistant tumors is retained.

Description

technical field [0001] The invention belongs to the technical field of tumor treatment, and in particular relates to a pharmaceutical composition for selectively killing drug-resistant tumors or efficiently killing at the nanometer level and an application thereof. Background technique [0002] Malignant tumor is a major disease that seriously endangers human life and health, and has become one of the main causes of death from diseases today. At present, the main treatment methods for malignant tumors include surgery, radiotherapy and chemotherapy. Chemotherapy is still the main way to deal with tumors because the recurrence and metastasis of tumors after surgery still requires chemotherapy. Clinicians can optimize the maximum curative effect and minimum toxicity by adjusting the dosage of drugs, helping patients prolong survival time and improve the prognosis of life quality. However, the generation of drug resistance of tumor cells leads to a decrease in the sensitivity ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61P35/00A61K131/00
CPCA61K36/185A61K2236/15A61K2236/333A61K2236/51A61K2236/53A61K2236/55A61P35/00
Inventor 王向涛敖惠王一安李好文付婧欣韩美华郭一飞
Owner INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI
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