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A middle ear anti-adhesion drug sustained release system and its preparation method and application

An anti-adhesion and drug technology, which is applied in the direction of drug combination, drug delivery, and pharmaceutical formulations, can solve the problems of poor pertinence and uneven sustained release of drugs, and achieve the effect of stable and long-term release

Active Publication Date: 2022-06-21
PUYI (SHANGHAI) BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The degradable and absorbable drug slow-release magnesium alloy stent involved in this invention not only has excellent mechanical properties, but also has good visibility under X-rays, and can improve and reduce the incidence of restenosis after stent implantation by selecting slow-release drugs , but it has the defects of uneven sustained drug release and poor pertinence at narrow sites

Method used

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  • A middle ear anti-adhesion drug sustained release system and its preparation method and application
  • A middle ear anti-adhesion drug sustained release system and its preparation method and application
  • A middle ear anti-adhesion drug sustained release system and its preparation method and application

Examples

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Effect test

Embodiment 1

[0063] This embodiment provides a middle ear anti-adhesion drug sustained-release system, the middle ear anti-adhesion drug sustained-release system includes a diaphragm, a coating applied on the surface of the diaphragm, and a drug, and the drug is loaded on the diaphragm and the coating layer. Its preparation method is:

[0064] Dissolve the polyglycolide copolymer with an intrinsic viscosity of 0.7dL / g in dichloromethane to make its mass concentration 7.5wt%, stir until the polyglycolide copolymer is completely dissolved, and then add furoic acid to the solution Mometasone to make its concentration 100μg / mL, stir until completely dissolved to obtain a mixed solution; add this mixed solution to a flat-bottomed container made of polytetrafluoroethylene, remove the lid of the container and place it under a fume hood, and wait for the dichloromethane to completely evaporate, The drug-containing film was obtained and placed in a vacuum environment of 37°C for 4 hours;

[0065]...

Embodiment 2

[0067] This embodiment provides a middle ear anti-adhesion drug sustained-release system, the middle ear anti-adhesion drug sustained-release system includes a diaphragm, a coating applied on the surface of the diaphragm, and a drug, and the drug is loaded on the diaphragm and the coating layer. Its preparation method is:

[0068] Dissolve L-polylactic acid with an intrinsic viscosity of 0.7dL / g in chloroform to make its mass concentration 7.5wt%, stir until L-polylactic acid is completely dissolved, and then add dexamethasone to the solution to make the concentration of 100 μg / mL, stir until completely dissolved to obtain a mixed solution; add this mixed solution to a flat-bottomed container made of polytetrafluoroethylene, remove the lid of the container and place it under a fume hood, and wait until the chloroform is completely volatilized to obtain a drug-containing film. It was placed in a vacuum environment at 37°C for 4h;

[0069] Dissolve L-polylactic acid with an in...

Embodiment 3

[0071] This embodiment provides a middle ear anti-adhesion drug sustained-release system, the middle ear anti-adhesion drug sustained-release system includes a diaphragm, a coating applied on the surface of the diaphragm, and a drug, and the drug is loaded on the diaphragm and the coating layer. The difference between the preparation method and Example 1 is only that the drug content in the prepared middle ear anti-adhesion drug sustained-release system coating is 350 μg, the drug content in the diaphragm is 350 μg, and other conditions are the same.

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Abstract

The invention relates to a middle ear anti-adhesion drug sustained release system and its preparation method and application. The middle ear anti-adhesion drug sustained release system includes a diaphragm, a coating coated on the surface of the diaphragm and a drug. The drug load on membranes and coatings. The middle ear anti-adhesion sustained-release drug system has a structure of an inner membrane and an outer coating, and both the membrane and the coating are loaded with medicine, so that the medicine can start to be released quickly and can achieve long-term release. By controlling the intrinsic viscosity of the film preparation raw materials and the coating preparation raw materials and controlling the mass ratio of the drug contained in the film and the coating, the drug release curve can be smoother and the drug release process more stable.

Description

technical field [0001] The invention belongs to the technical field of controlled drug release, and in particular relates to a middle ear anti-adhesion drug sustained-release system and a preparation method and application thereof. Background technique [0002] Otitis media is an inflammatory disease involving all or part of the structures of the middle ear (including the Eustachian tube, tympanic cavity, tympanic sinus, and mastoid air cells), and it is more common in children. Among them, the conductive hearing loss caused by adhesive otitis media is due to the formation of fibrosis and adhesion between the middle ear sound transmission structures and with the tympanic wall caused by certain factors, thereby causing the movement disorder of the middle ear sound transmission structure system. Middle ear adhesion refers to the adhesion of the fibrous connective tissue formed by the fibrous tissue and scar hyperplasia of the middle ear, which has a serious negative impact on ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/70A61K47/34A61K47/10A61K31/58A61K31/573A61P27/16
CPCA61K47/10A61K47/34A61P27/16A61K9/7007A61K31/573A61K31/58
Inventor 高下杨瑞晏伟夏佩佩魏征
Owner PUYI (SHANGHAI) BIOTECHNOLOGY CO LTD
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