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Method for preparing fructus corni or cornus formula granule by using continuous dynamic countercurrent extraction technology

A technology of dynamic countercurrent and formula granules, which is applied in countercurrent extraction, separation methods, pharmaceutical formulas, etc., can solve the problems that have not yet been seen in cornus or wine cornus formula granules, so as to improve the physical dissolution transfer rate, reduce degradation damage, Reduce the effect of chemical degradation

Inactive Publication Date: 2019-04-05
GUANGDONG YIFANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the preparation of cornus or wine cornus formula granules by continuous dynamic countercurrent extraction process

Method used

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  • Method for preparing fructus corni or cornus formula granule by using continuous dynamic countercurrent extraction technology
  • Method for preparing fructus corni or cornus formula granule by using continuous dynamic countercurrent extraction technology
  • Method for preparing fructus corni or cornus formula granule by using continuous dynamic countercurrent extraction technology

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] A method for preparing cornus formula granules by using a continuous dynamic countercurrent extraction process, comprising the steps of:

[0047] a. Selecting and vibrating the cornus medicinal materials to remove impurities and residual fruit cores to obtain cornus decoction pieces;

[0048] b. Moisten the cornus decoction pieces with 2 times of water, and continuously input the extraction tube of the spiral continuous countercurrent extraction machine (two-stage 10-section tube structure) from the feed port, and pass through a set of spiral structures in the extraction tube. The material is continuously pushed forward to the slag discharge outlet of the extraction tube, and 14 times the amount of hot water at 95°C is continuously added to the end of the extraction tubes at each level for continuous countercurrent extraction for 1 hour. The hot water and the material flow in reverse to each level of extraction tube. The front end of the lifting tube discharges the liqu...

Embodiment 2

[0053] A method for preparing cornus formula granules by using a continuous dynamic countercurrent extraction process, comprising the steps of:

[0054] a. Selecting and vibrating the cornus medicinal materials to remove impurities and residual fruit cores to obtain cornus decoction pieces;

[0055] b. Moisten the cornus decoction pieces with 2 times of water, and continuously input the extraction tube of the spiral continuous countercurrent extraction machine (two-stage 10-section tube structure) from the feed port, and pass through a set of spiral structures in the extraction tube. The material is continuously pushed forward to the slag discharge outlet of the extraction tube, and 14 times the amount of hot water at 95°C is continuously added to the end of the extraction tubes at each level for continuous countercurrent extraction for 1 hour. The hot water and the material flow in reverse to each level of extraction tube. The front end of the lifting tube discharges the liqu...

Embodiment 3

[0060] A method for preparing cornus formula granules by using a continuous dynamic countercurrent extraction process, comprising the steps of:

[0061] a. Selecting and vibrating the cornus medicinal materials to remove impurities and residual fruit cores to obtain cornus decoction pieces;

[0062] b. Moisten the cornus decoction pieces with 2 times of water, and continuously input the extraction tube of the spiral continuous countercurrent extraction machine (two-stage 10-section tube structure) from the feed port, and pass through a set of spiral structures in the extraction tube. The material is continuously pushed forward to the slag discharge outlet of the extraction tube, and 14 times the amount of hot water at 80°C is continuously added to the end of the extraction tubes at each level for continuous countercurrent extraction for 1 hour. The front end of the lifting tube discharges the liquid, collects the extract, and discharges the cornus medicinal residue after squee...

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Abstract

The invention discloses a method for preparing a fructus corni or cornus formula granule by using a continuous dynamic countercurrent extraction technology. The method comprises the following steps: a) removing impurities and residual kernels from fructus corni or cornus; b) continuously putting fructus corni or cornus pieces into extraction pipes of a continuous countercurrent extraction device,continuously reverse adding hot water into the tail ends of all-level extraction pipes, continuously dynamic countercurrent extracting, collecting an extracting solution and discharging drug residue;c) cooling and filtering the extracting solution, reducing pressure for concentrating filtrate into a clear paste; d) spray-drying the clear paste, thereby acquiring dry extract powder; e) dryly granulating the dry extract powder, thereby acquiring the end product. According to the invention, the production processes of continuous countercurrent extraction, high-temperature instant sterilization,vacuum concentration, spray drying and dry granulation are adopted, and various technological parameters are researched, so that content of active ingredients in the formula granule can continuously and stably reach a higher level and the product quality of the fructus corni or cornus formula granule can be promoted.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine formula granules, and in particular relates to a method for preparing cornus cornus or wine cornus formula granules by using a continuous dynamic countercurrent extraction process. Background technique [0002] Cornus officinalis is the dried and mature pulp of Cornus officinalis Sieb.et Zucc., a plant of the family Cornaceae. It has the effects of nourishing the liver and kidney, and astringent and solidifying. It is used for dizziness, tinnitus, waist and knee pain, impotence and seminal emission, enuresis Sweating prostration, internal heat and quenching thirst. The main components of cornus and wine cornus are iridoids, triterpenes, tannins, flavonoids, organic acids, polysaccharides, volatile components, etc. Among them, iridoids are one of the main active components, and most of them are related to Sugars link to form iridoid glycosides. Among the iridoid glycosides, l...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/40A61K9/16B01D11/02A61K131/00
CPCA61K9/1652A61K36/40A61K2236/331A61K2236/39A61K2236/51A61K2236/53B01D11/02B01D2011/002
Inventor 魏梅程学仁刘燎原孙冬梅林伟雄梁志毅张志鹏黄瑶蔡盛康
Owner GUANGDONG YIFANG PHARMA
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