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Substituted pyridazinone compound

A compound, solvent compound technology, applied in the field of medicine, can solve problems such as poor absorption, distribution, metabolism and/or excretion, rise, cost of side effects treatment, etc.

Active Publication Date: 2019-04-05
SHENZHEN TARGETRX INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Poor absorption, distribution, metabolism and / or excretion (ADME) properties are known to be a major reason for failure of many drug candidates in clinical trials
Many currently marketed drugs also limit their application range due to poor ADME properties
The rapid metabolism of drugs will cause many drugs that can treat diseases with high efficiency to be eliminated from the body too quickly, making it difficult to become a drug
Although frequent or high-dose medication may solve the problem of rapid drug clearance, this method will bring problems such as poor patient compliance, side effects caused by high-dose medication, and increased treatment costs
In addition, rapidly metabolizing drugs may also expose patients to undesirable toxic or reactive metabolites
[0008] Although MGL-3196 as a THR-β agonist can effectively treat a variety of diseases, it is still challenging to find new compounds that have the beneficial effects of thyroid hormones while avoiding adverse effects, have good oral bioavailability and are druggable sex work

Method used

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  • Substituted pyridazinone compound
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Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment approach

[0047] compound

[0048] The present invention provides a compound of formula (I), or a pharmaceutically acceptable salt, prodrug, hydrate or solvate, crystal form, stereoisomer or isotopic variant thereof:

[0049]

[0050] in,

[0051] R 1 , R 2 , R 3 and R 4 each independently selected from hydrogen or deuterium;

[0052] x 1 and x 2 each independently selected from CH 3 、CD 3 、CHD 2 or CH 2 D;

[0053] The condition is that if X 1 and x 2 Both are CH 3 , then R 1 , R 2 , R 3 and R 4 At least one of is deuterium.

[0054] As a preferred embodiment of the present invention, the compound in formula (I) contains at least one deuterium atom, more preferably one deuterium atom, more preferably two deuterium atoms, more preferably three deuterium atoms, more preferably four deuterium atoms , more preferably five deuterium atoms, more preferably six deuterium atoms, more preferably seven deuterium atoms, more preferably eight deuterium atoms, more preferably...

Embodiment 1

[0138] Example 1 2-(3,5-dichloro-4-((6-oxo-5-(propan-2-yl-1,1,1-d 3 )-1,6-dihydropyridazine-3- Preparation of (yl)oxy)phenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile (compound M-1).

[0139]

[0140] Synthesize using the following route:

[0141]

[0142]

[0143] Synthesis of Step 1 Compound 2

[0144] Compound 1 (5.5g, 31.6mmol) and sodium ethoxide (2.6g, 37.9mmol) were added to ethanol (30ml) in turn, and the solution was stirred at 70°C for 0.5h, cooled to room temperature, and deuterated iodomethane ( 5.0g, 34.7mmol) was slowly added dropwise to the above solution, the reaction solution was stirred at room temperature for 20h, most of the solvent was removed, the residual solution was extracted with dichloromethane (40ml×2), the organic phases were combined, anhydrous sodium sulfate After drying, the solvent was removed to obtain 5.1 g of a brownish-red oil, with a yield of 85%.

[0145] Synthesis of Step 2 Compound 3

[0146] Potassium ...

Embodiment 2

[0159] Example 2 2-(3,5-dichloro-4-((6-oxo-5-(propan-2-yl-1,1,1,3,3,3-d 6 )-1,6-dihydro Pyridazin-3-yl)oxy)phenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile (compound M-2 ) system prepare.

[0160]

[0161] Synthesize using the following route:

[0162]

[0163] Synthesis of step 1 compound 13

[0164] Compound 12 (4.0g, 25.0mmol) and sodium ethoxide (4.0g, 57.5mmol) were added to ethanol (30ml) in sequence, the solution was stirred at 70°C for 0.5h, cooled to room temperature, and deuterated iodomethane ( 8.0g, 55.0mmol) was slowly added dropwise to the above solution, the reaction solution was stirred at room temperature for 20h, most of the solvent was removed, the residual solution was extracted with dichloromethane (50ml×2), the organic phases were combined, anhydrous sulfuric acid Dry over sodium, and remove the solvent to obtain 3.8 g of brown-red oily substance, yield 78%.

[0165] Synthesis of Step 2 Compound 14

[0166] Potassium hyd...

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Abstract

The invention provides a pharmaceutical composition of a substituted pyridazinone compound, and application thereof. The substituted pyridazinone compound is a compound as shown in formula (I), or a pharmaceutically acceptable salt, prodrug, hydrate or solvent compound, crystalline form, stereoisomer or isotopic variant thereof. The compound, namely a THR-beta agonist, can be used for treating and / or preventing diseases regulated by thyroid hormone analogs.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a substituted pyridazinone compound, a composition containing the compound and its application. More specifically, the present invention relates to certain deuterium substituted 2-(3,5-dichloro-4-((5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl )oxy)phenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile, these deuterium-substituted compounds can be used as THR-β agonists, and can be used to treat and / or prevent diseases regulated by thyroid hormone analogs, and these deuterium-substituted compounds have better pharmacokinetic properties. Background technique [0002] Thyroid hormone (TH) is produced by the thyroid gland and is secreted into the circulatory system (hypothalamus / pituitary / thyroid system) in two different forms: 3,5,3',5'-tetraiodo-L-thyroid orthyronine (T4) and 3,5,3'-triiodo-L-thyronine (T3). Although T4 is the predominant form secreted by...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D403/10A61K31/53A61P3/06A61P3/04A61P3/10A61P1/16A61P9/10A61P9/00A61P5/16A61P35/00
CPCA61P1/16A61P3/04A61P3/06A61P3/10A61P9/00A61P9/10A61P35/00C07D403/12A61P5/14C07B59/002C07B2200/05C07D403/10
Inventor 王义汉刘志强
Owner SHENZHEN TARGETRX INC
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