Unlock instant, AI-driven research and patent intelligence for your innovation.

Florfenicol solution and preparation method thereof

A technology of florfenicol solution, which is applied in the field of florfenicol solution and its preparation, can solve the problems of inconvenient clinical application and low water solubility of florfenicol, and achieve improved bioavailability, good therapeutic effect, and preparation good stability effect

Inactive Publication Date: 2019-04-12
FOSHAN STANDARD BIO TECH
View PDF3 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a florfenicol solution and preparation method thereof, aiming to solve the problem of extremely low water solubility of florfenicol and inconvenient clinical application

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Florfenicol solution and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A florfenicol solution, in every 100g solution, 10g of florfenicol, 15g of dimethylformamide, 20g of propylene glycol, 0.02g of butylated hydroxyanisole, 0.01g of disodium edetate, polyethylene glycol Alcohol-400 1g, the balance being ethanol.

[0024] The preparation method of above-mentioned Florfenicol solution, concrete steps are as follows:

[0025] (1), take Florfenicol accurately by formula quantity, add dimethylformamide, stir until dissolving;

[0026] (2), accurately weigh butylated hydroxyanisole according to the formula quantity, and dissolve with an appropriate amount of propylene glycol;

[0027] (3), accurately weigh disodium ethylenediaminetetraacetate according to the formula quantity, add a small amount of water (not exceeding 0.2% of the total amount) to dissolve it;

[0028] (4), add the materials dissolved in steps (1), (2), (3) and the remaining components weighed according to the weight parts into the liquid mixing tank in turn, stir evenly, use...

Embodiment 2

[0030] A florfenicol solution, in every 100g solution, 5g of florfenicol, 20g of dimethylformamide, 22g of propylene glycol, 0.02g of butylated hydroxyanisole, 0.02g of disodium ethylenediaminetetraacetic acid, polyethylene glycol Alcohol-400 3g, the balance being ethanol.

[0031] The preparation method of above-mentioned Florfenicol solution, concrete steps are as follows:

[0032] (1), take Florfenicol accurately by formula quantity, add dimethylformamide, stir until dissolving;

[0033] (2), accurately weigh butylated hydroxyanisole according to the formula quantity, and dissolve with an appropriate amount of propylene glycol;

[0034] (3), accurately weigh disodium ethylenediaminetetraacetate according to the formula quantity, add a small amount of water (not exceeding 0.2% of the total amount) to dissolve it;

[0035] (4), add the materials dissolved in steps (1), (2), (3) and the remaining components weighed according to the weight parts into the liquid mixing tank in...

Embodiment 3

[0037] A florfenicol solution, in every 100g solution, 15g of florfenicol, 18g of dimethylformamide, 15g of propylene glycol, 0.01g of butylated hydroxyanisole, 0.02g of disodium edetate, polyethylene glycol Alcohol-400 2g, the balance being ethanol.

[0038] The preparation method of above-mentioned Florfenicol solution, concrete steps are as follows:

[0039] (1), take Florfenicol accurately by formula quantity, add dimethylformamide, stir until dissolving;

[0040] (2), accurately weigh butylated hydroxyanisole according to the formula quantity, and dissolve with an appropriate amount of propylene glycol;

[0041] (3), accurately weigh disodium ethylenediaminetetraacetate according to the formula quantity, add a small amount of water (not exceeding 0.2% of the total amount) to dissolve it;

[0042] (4), add the materials dissolved in steps (1), (2), (3) and the remaining components weighed according to the weight parts into the liquid mixing tank in turn, stir evenly, use...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention discloses a florfenicol solution. The florfenicol solution is characterized by comprising the following preparation raw materials: florfenicol, dimethylformamide, propylene glycol, an antioxidant, a chelating agent, a dispersing agent ethanol and water. The florfenicol solution conducts targeting positioning to exert excellent medicinal effects on organisms, is less in use amount, rapid in effects, long in a half-life period, and prolonged in effective blood drug concentration maintaining in body; a preparation is good in stability, also effectively improves bioavailability of the florfenicol, and particularly solves a problem that poorly soluble drugs are unsuitable for drinking water to treat animal diseases; and the provided florfenicol solution is simple in a preparation method, simple in production technology, excellent in therapeutic effects and easy to achieve industrialization.

Description

technical field [0001] The invention relates to a florfenicol solution and a preparation method thereof. Background technique [0002] Florfenicol (Florfenicol, FFC), also known as fluprofen and fluthiamphenicol, is a new generation of amide alcohol chemically synthesized broad-spectrum antibacterial drugs, which inhibit the synthesis of bacterial proteins by binding to the ribosomal 50S subunit. It has strong antibacterial activity against a variety of Gram-positive bacteria and Gram-negative bacteria. It is an excellent broad-spectrum antibiotic for animals. It has the characteristics of broad antibacterial spectrum, good absorption, wide distribution in the body, safety and high efficiency, etc. , especially eliminates the disadvantage of chloramphenicol destroying the hematopoietic function of bone marrow, and has no potential aplastic anemia, teratogenic, carcinogenic and mutagenic effects. In veterinary medicine, it is widely used in the treatment of livestock and pou...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/08A61K47/10A61K47/18A61K31/165A61P31/04
CPCA61K9/08A61K31/165A61K47/10A61K47/18A61K47/183A61P31/04
Inventor 邓婵开刘肖娟袁增辉谭志坚陈艺青黎剑坤符德文
Owner FOSHAN STANDARD BIO TECH