Composite nano micelle for multi-mode treatment of nasopharyngeal carcinoma and preparation method and application thereof

A nanomicelle, nasopharyngeal cancer technology, applied in photodynamic therapy, medical preparations containing active ingredients, drug combinations, etc., can solve the problems of limited application, difficulty in enriching target tissues, etc. Good biodegradability, good biocompatibility
CN109620801AInactive Publication Date: 2019-04-16TIANJIN UNIV
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Patent Information

Authority / Receiving Office
CN Ā· China
Current Assignee / Owner
TIANJIN UNIV
Publication Date
2019-04-16
Estimated Expiration
Not applicable Ā· inactive patent

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Abstract

The invention belongs to the field of preparation of composite micelle entrapped drugs, and particularly relates to a composite nano micelle for multi-mode treatment of nasopharyngeal carcinoma and apreparation method and application thereof. The composite nano micelle for multi-mode treatment of nasopharyngeal carcinoma is characterized by comprising Bangladesh rose red and an amphiphilic peptide nano micelle for encapsulating the Bangladesh rose red. According to the invention, the amphiphilic peptide of C18-GRRRRRRRRGDScontaining a tripeptide sequence of arginine, glycine and aspartic is self-assembled into a nano micelle, and the inside of the nano micelle is wrapped with Bangladesh red; the results show that the a combined therapy group has obvious inhibitory effect on CNE-2Z tumor during intravenous injection. During intratumor injection, a photodynamic therapy group (RBNs+Laser) with laser added alone, a sonodynamic therapy group (RBNs+US) with ultrasound added alone and a combination therapy group (RBNs+Laser+US) all have a significant inhibitory effect on tumor growth.
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Description

technical field

[0001] The invention belongs to the field of preparation of compound micelle-loaded drugs, and in particular relates to a compound nano-micelle for multi-mode treatment of nasopharyngeal carcinoma and its preparation method and application. Background technique

[0002] Nasopharyngeal carcinoma is one of the most common malignant tumors in southern my country. It mainly occurs in Guangdong Province and Guangxi Zhuang Autonomous Region, and it brings great harm to the health of the people in high-incidence areas. Radiation therapy is the first choice for the treatment of nasopharyngeal carcinoma without distant metastasis, and it has a good control efficiency for early nasopharyngeal carcinoma. For advanced nasopharyngeal carcinoma, radiotherapy combined with chemotherapy is often used clinically. However, the acute toxic side effects associated with radiation therapy and chemotherapy drugs have relatively large toxic side effects on the human body, and some ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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