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Mixture of total tannin and epicatechin in wild buckwheat and extraction method and application thereof

A technology of epicatechin and extraction method, which is applied to the mixture of total tannins and epicatechin in golden buckwheat and its extraction field, which can solve the problem of poor stability of the mixture, limiting the curative effect of golden buckwheat extract, and the extraction of golden buckwheat extract Low rate and other issues

Inactive Publication Date: 2019-04-16
HUAYI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] However, the golden buckwheat extract prepared by the above method has the problems of low extraction rate and poor stability of the mixture obtained by extraction, which limits the curative effect of the golden buckwheat extract to a large extent

Method used

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  • Mixture of total tannin and epicatechin in wild buckwheat and extraction method and application thereof

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Experimental program
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Effect test

Embodiment 1

[0051] 1. Extraction method: take 14430g of golden buckwheat, crush it into particles with a particle size of 2mm, and extract it under reflux with 95% ethanol for four times, the quality of the extraction solvent is respectively 4, 4, 3, and 2 times of the golden buckwheat grain quality, The extraction time is 60, 30, 30, and 10 minutes in sequence, the extracts are combined, filtered, and the filtrate is concentrated under reduced pressure below 60°C to a relative density of 1.06 (55°C); ℃), suspended, and left standing overnight; the supernatant was filtered and separated by macroporous adsorption resin (D101) column chromatography, the adsorption flow rate was 200L / h; first eluted with water until the effluent was colorless, followed by 80 % ethanol until the eluate has no reaction with the ferric chloride test solution, collect the 80% ethanol eluate, concentrate under reduced pressure below 60°C to a relative density of 1.02 (55°C), and spray dry (the inlet temperature is...

Embodiment 2

[0077] 1. Extraction method: take 14430g of golden buckwheat, crush it into particles with a particle size of 3mm, and extract it under reflux with 93% ethanol for four times. The extraction time is 60, 30, 30, and 10 minutes in sequence, the extracts are combined, filtered, and the filtrate is concentrated under reduced pressure below 60°C to a relative density of 1.09 (55°C); add 20 times the amount of extract hot water (temperature is 80 ℃), suspended, and left standing overnight; the supernatant was filtered and separated by macroporous adsorption resin (AB-8) column chromatography, and the adsorption flow rate was 400L / h; first, it was eluted with water until the effluent was colorless, and then Elute with 80% ethanol until the eluate has no reaction with the ferric chloride test solution, collect the 80% ethanol eluate, concentrate under reduced pressure below 60°C to a relative density of 1.04 (55°C), spray dry (into the air) The temperature is 200° C., the air outlet t...

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Abstract

The invention provides a method for extracting a mixture of total tannin and epicatechin in wild buckwheat, and belongs to the technical field of pharmaceutical preparations. According to the method,the tannin and the epicatechin in the wild buckwheat are extracted more completely by defining the specific particle size of the wild buckwheat pulverized and the temperature of hot water in the suspension process, and the transfer rate of effective substances and the yield of spray drying products are improved. At the same time, the spray drying products are more fine in form, good in dispersibility and low in moisture by limiting the specific relative density and combining the special purification technology of macroporous adsorption resin and the spray drying technology, the obtained mixture of the total tannin and the epicatechin is good in stability, the filling capsule quality is good, and the mixture is easy to absorb by a patient.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a mixture of total tannins and epicatechin in golden buckwheat and an extraction method and application thereof. Background technique [0002] Tumor is a new organism formed by the body under the action of various carcinogenic factors, a certain cell in the local tissue loses its normal regulation of its growth at the gene level, resulting in abnormal clonal proliferation. Tumors are generally divided into benign and malignant. All malignant tumors are collectively called cancer. [0003] Golden buckwheat (Rhizoma Fagopyri Cymosi) is a Polygonaceae plant, also known as tartary buckwheat, wild bridge buckwheat, and sky buckwheat. It is cool in nature, pungent and bitter in taste, and has the effects of clearing heat and detoxifying, promoting blood circulation and removing blood stasis, strengthening the spleen and promoting dampness. The extract of the medi...

Claims

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Application Information

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IPC IPC(8): A61K36/70A61P35/00
CPCA61K36/70A61K2236/33A61K2236/39A61K2236/51A61K2236/55A61P35/00
Inventor 李昌福商国懋吴德海张宸
Owner HUAYI PHARMA
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