Anticancer drug composition and preparation method and application thereof

A technology of anti-tumor drug and composition, applied in the field of anti-tumor drug composition and its preparation

Inactive Publication Date: 2019-04-19
HUAYI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The extract of the drug has the ability to reduce the side effects of tumor radiotherapy and chemotherapy and has synergistic effect on tumo...

Method used

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  • Anticancer drug composition and preparation method and application thereof

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preparation example Construction

[0043] The present invention also provides a preparation method of the antitumor pharmaceutical composition described in the above technical scheme, comprising the following steps:

[0044] The antitumor drug composition is obtained by mixing the total tannins extracted from golden buckwheat and the mixture of epicatechin, microcrystalline cellulose, sodium carboxymethyl starch and starch. In the present invention, there is no special limitation on the specific mixing method, and a mixing method well known to those skilled in the art can be used.

[0045] After the mixing is completed, the present invention preferably dry-granulates the obtained mixture and fills it into capsules to obtain the capsule preparation of the tumor drug composition.

[0046] The present invention also provides the application of the antitumor pharmaceutical composition described in the above technical scheme or the antitumor pharmaceutical composition prepared by the preparation method described in ...

Embodiment 1

[0051] 1. Extraction method: take 14430g of golden buckwheat, crush it into particles with a particle size of 2mm, and extract it under reflux with 95% ethanol for four times, the quality of the extraction solvent is respectively 4, 4, 3, and 2 times of the golden buckwheat grain quality, The extraction time is 60, 30, 30, and 10 minutes in sequence, the extracts are combined, filtered, and the filtrate is concentrated under reduced pressure below 60°C to a relative density of 1.06 (55°C); ℃), suspended, and left standing overnight; the supernatant was filtered and separated by macroporous adsorption resin (D101) column chromatography, the adsorption flow rate was 200L / h; first eluted with water until the effluent was colorless, followed by 80 % ethanol until the eluate has no reaction with the ferric chloride test solution, collect the 80% ethanol eluate, concentrate under reduced pressure below 60°C to a relative density of 1.02 (55°C), and spray dry (the inlet temperature ...

Embodiment 2

[0094] 1. Extraction method: take 14430g of golden buckwheat, crush it into particles with a particle size of 3mm, and extract it under reflux with 93% ethanol for four times. The extraction time is 60, 30, 30, and 10 minutes in sequence, the extracts are combined, filtered, and the filtrate is concentrated under reduced pressure below 60°C to a relative density of 1.09 (55°C); add 20 times the amount of extract hot water (temperature is 80 ℃), suspended, and left standing overnight; the supernatant was filtered and separated by macroporous adsorption resin (AB-8) column chromatography, and the adsorption flow rate was 400L / h; first, it was eluted with water until the effluent was colorless, and Elute with 80% ethanol until the eluate has no reaction with the ferric chloride test solution, collect the 80% ethanol eluate, concentrate under reduced pressure below 60°C to a relative density of 1.04 (55°C), spray dry (into the air) The temperature is 200° C., the air outlet temp...

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Abstract

The invention provides an anticancer drug composition and a preparation method and application thereof, and belongs to the technical field of pharmaceutical preparations. By limiting a specific particle size of smashed fagopyri dibotryis rhizoma and the temperature of hot water in a suspension process, tannin and epicatechin in fagopyri dibotryis rhizoma are more completely extracted, and the extraction rate is increased; by limiting specific relative density, in combination with a purification technology, a spray drying technology and a dry extrusion granulation technology which are exclusivefor microporous adsorption resin, products obtained after spray drying are finer in appearance, good in dispersing and low in moisture content, completely fluffy powder obtained after spray drying easily fills capsule shells and can be made into capsules, and drug specifications are met; the obtained mixture of total tannin and epicatechin is good in stability and high in transfer rate, and the filled capsules are good in quality and easily absorbed by patients; the prepared anticancer drug composition has the effects of promoting blood circulation, removing blood stasis, clearing away heat and toxic materials, eliminating pathogen and strengthening vital energy. In combination with radiotherapy and chemotherapy, the prepared anticancer drug composition has synergistic and attenuation effects; when in single use, the anticancer drug composition can be used for treating patients who suffer from lung cancer and are not suitable for radiotherapy and chemotherapy.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to an antitumor pharmaceutical composition and its preparation method and application. Background technique [0002] Tumor is a new organism formed by the body under the action of various carcinogenic factors, a certain cell in the local tissue loses its normal regulation of its growth at the gene level, resulting in abnormal clonal proliferation. Tumors are generally divided into benign and malignant. All malignant tumors are collectively called cancer. [0003] Golden buckwheat (Rhizoma Fagopyri Cymosi) is a Polygonaceae plant, also known as tartary buckwheat, wild bridge buckwheat, and sky buckwheat. It is cool in nature, pungent and bitter in taste, and has the effects of clearing heat and detoxifying, promoting blood circulation and removing blood stasis, strengthening the spleen and promoting dampness. The extract of the medicine can reduce the toxic and...

Claims

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Application Information

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IPC IPC(8): A61K36/70A61K9/48A61P35/00
CPCA61K36/70A61K9/4866A61K2236/15A61K2236/333A61K2236/39A61K2236/51A61K2236/55A61P35/00
Inventor 李昌福商国懋吴德海董建华
Owner HUAYI PHARMA
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