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Highly adaptable, lightweight and efficient dressing

An applicable and lightweight technology, applied in medical science, absorbent pads, bandages, etc., can solve the problems of high production cost, poor applicability, limited effect of wound hemostasis and wound healing, etc., to protect the wound surface, prevent excessive water evaporation, Accelerate the effect of wound hemostasis and wound healing

Inactive Publication Date: 2019-04-19
江西高大生物医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the deficiencies of the prior art, the purpose of the present invention is to provide a dressing with strong applicability, lightness and high efficiency. Limited technical problems; the dressing is simple, practical, stable in performance, lightweight, non-toxic and side effects, and has a wide range of applications. At the same time, it effectively integrates the performance characteristics of carboxymethyl chitosan, polyhexamethylene biguanide and silicone rubber. It has a strong effect of promoting wound repair. In addition, the dressing is cost-effective and suitable for industrialization

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A kind of preparation of the silicone rubber film dressing that joins carboxymethyl chitosan sponge, concrete steps are:

[0023] Step 1. Weigh a certain amount of carboxymethyl chitosan, polyhexamethylene biguanide, and mannitol, mix and dissolve them in purified water, and prepare them into concentrations of 0.5%, 0.05%, and 1.0%, respectively, to obtain a dispersion .

[0024] Step 2: Ultrasonic defoaming of the obtained dispersion liquid for 20 minutes.

[0025] Step 3: Put the dispersion liquid after ultrasonic defoaming into the template, put it into the template, and place it at -35°C for freeze-drying for 48 hours to obtain a sponge layer. The thickness of the sponge layer is controlled to be 3mm.

[0026] Step 4. Mix the addition-type liquid silicone rubber A / B evenly in a mass ratio of 1:1.

[0027] Step 5. Place the uniformly mixed addition-type liquid silicone rubber on the surface of the prepared sponge layer in the template, and place it at a temperature...

Embodiment 2

[0029] A kind of preparation of the silicone rubber film dressing that joins carboxymethyl chitosan sponge, concrete steps are:

[0030] Step 1. Weigh a certain amount of carboxymethyl chitosan, polyhexamethylene biguanide, and glycine, mix and dissolve them in purified water, and prepare them to concentrations of 0.6%, 0.1%, and 0.5%, respectively, to obtain a dispersion.

[0031] Step 2: Ultrasonic defoaming of the obtained dispersion liquid for 25 minutes.

[0032] Step 3: Put the dispersion liquid after ultrasonic defoaming into the template, put it into the template, and place it at -40°C for 36 hours to freeze-dry to obtain a sponge layer, and control the thickness of the sponge layer to 2mm.

[0033] Step 4. Mix the addition-type liquid silicone rubber A / B evenly in a mass ratio of 1:1.

[0034] Step 5. Place the uniformly mixed addition-type liquid silicone rubber on the surface of the prepared sponge layer in the template, and place it at a temperature of 90° C. for ...

Embodiment 3

[0036] A kind of preparation of the silicone rubber film dressing that joins carboxymethyl chitosan sponge, concrete steps are:

[0037] Step 1. Weigh a certain amount of carboxymethyl chitosan, polyhexamethylene biguanide, and polyvinylpyrrolidone, mix and dissolve them in purified water, and prepare them into concentrations of 0.8%, 0.15%, and 0.1%, respectively, to obtain dispersed liquid.

[0038] Step 2: Ultrasonic defoaming of the obtained dispersion liquid for 30 minutes.

[0039]Step 3. Put the dispersion liquid after ultrasonic defoaming into the template, put it into the template, and place it at -45°C for freeze-drying for 24 hours to obtain a sponge layer. The thickness of the sponge layer is controlled to be 1.5mm.

[0040] Step 4. Mix the addition-type liquid silicone rubber A / B evenly in a mass ratio of 1:1.

[0041] Step 5. Place the uniformly mixed addition-type liquid silicone rubber on the surface of the prepared sponge layer in the template, and place it ...

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PUM

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Abstract

The invention discloses a highly adaptable, lightweight and efficient dressing. The dressing is intended to solve the technical problem that an existing dressing has high manufacturing cost and poor applicability, and has limited effects on promoting wound hemostasis and wound surface healing; the dressing is of a double layer composite structure, one layer is a sponge layer, the sponge layer component comprises carboxymethyl chitosan, polyhexamethylene biguanide and a lyophilized protective agent; the other layer is an additive formed silicone rubber film. The dressing is simple and practical, stable in performance, light in weight, non-toxic and side-effect and wide in application range, effectively integrates the performance characteristics of the carboxymethyl chitosan, the polyhexamethylene biguanide and a silicone rubber, has a strong promotion effect on wound repair, in addition, has high cost performance, and is suitable for industrial promotion.

Description

technical field [0001] The invention belongs to the application field of medical materials, and in particular relates to a dressing with strong applicability, portability and high efficiency. Background technique [0002] The skin is a barrier to protect the body, but it is often subjected to various traumas in life, such as contusions, cuts, scalds, burns and chemical corrosion, etc. At the same time, skin wounds are likely to cause microbial invasion, which threatens human health. Therefore, the ideal treatment mode for various skin wounds is to control wound infection and promote rapid wound healing through dressings, and make it leave no scars as much as possible. Among them, dressings are medical materials used to wrap and cover wounds. Studies on wound healing have shown that the purpose of using dressings is not only to cover wounds, but also to promote wound healing. Therefore, as the pathophysiology of wound healing process With in-depth research, people's understa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/26A61L15/28A61L15/42A61L15/46
CPCA61L15/26A61L15/28A61L15/425A61L15/46A61L2300/206A61L2300/232A61L2300/404C08L83/04C08L79/00C08L5/08
Inventor 李雪波何显文吴联勇
Owner 江西高大生物医疗科技有限公司