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Biomarker combination for early diagnosis and prediction for Alzheimer's disease or mild cognitive impairement for the old, and application and measuring method thereof

An Alzheimer's disease, biomarker technology, applied in the biological field, can solve the problems of time-consuming, expensive, invasive, etc., achieve high sensitivity, high specificity, improve clinical efficacy and quality of life.

Inactive Publication Date: 2019-05-03
马红华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Considerable progress has been made in recent years using neuroimaging, genetic testing, and testing of body fluid neurochemistry, however these methods are either invasive, time-consuming, and expensive

Method used

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  • Biomarker combination for early diagnosis and prediction for Alzheimer's disease or mild cognitive impairement for the old, and application and measuring method thereof
  • Biomarker combination for early diagnosis and prediction for Alzheimer's disease or mild cognitive impairement for the old, and application and measuring method thereof
  • Biomarker combination for early diagnosis and prediction for Alzheimer's disease or mild cognitive impairement for the old, and application and measuring method thereof

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Embodiment Construction

[0029] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Generally, the nomenclature used in the present invention and the following experimental methods are well known or commonly used in the art.

[0030] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0031] It should be noted that, in the case of no conflict, the embodiments of the present invention and the features in the em...

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Abstract

The invention discloses a biomarker combination for early diagnosis and prediction for Alzheimer's disease or mild cognitive impairement for the old, and application and measuring method thereof. Thebiomarker combination comprises one or combination of arachidonic acid, thymine, linoleic acid, palmitic acid, palmitoleic acid, myristic acid, petroselinic acid, GLCA, CA, and DCA and the like. According to the invention, the serum or plasma of an old patient with the Alzheimer's disease or mild cognitive impairement is processed by a liquid / gas chromatography mass spectrometry analysis method. The diagnosis marker can be used for preparing a kit; the detection method has characteristics of high sensitivity and high specificity and has the high sensitivity and specificity in mild cognitive impairement diagnosis for the old.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to the early diagnosis of Alzheimer's disease or mild senile cognitive impairment, a biomarker combination for diagnosis and prediction, an application and a determination method thereof. Background technique [0002] Alzheimer's disease (Alzheimer's disease, AD) is a progressive neurodegenerative disease, which constitutes the main cause of senile dementia, accounting for about 60-70% of senile dementia patients. According to the 2018 World Alzheimer's Disease Report, there are approximately 46.8 million AD patients worldwide, and the number of patients is expected to double every 20 years, reaching 74.7 million by 2030. The number of AD patients in my country has exceeded 10 million, ranking first in the world. [0003] The etiology of Alzheimer's disease (AD) is unclear, but it is generally believed that the main pathogenesis includes altered metabolism of amyloid precursor protein,...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/72G01N30/06G01N30/88G01N33/50
Inventor 马红华
Owner 马红华
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