Supercharge Your Innovation With Domain-Expert AI Agents!

Liposome-stabilized oil-in-water pickering emulsion and preparation method thereof

A liposome, oil-in-water technology, applied in liposome delivery, emulsion delivery, preparations for skin care, etc., can solve the problem of inability to maximize the use of resources, single embedded material, uneven particle size distribution, etc. problems, to achieve good practical use value, improve stability, and improve the effect of taste

Active Publication Date: 2021-03-02
ZHEJIANG GONGSHANG UNIVERSITY
View PDF8 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, the traditional oil-in-water Pickering emulsion has problems such as uneven particle size distribution and emulsion layering caused by particle aggregation. At the same time, inorganic substances or low-toxicity substances are often used as ultra-fine particle emulsifiers, and the embedding is single, so it is impossible to achieve resource recovery. maximize the use of

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Liposome-stabilized oil-in-water pickering emulsion and preparation method thereof
  • Liposome-stabilized oil-in-water pickering emulsion and preparation method thereof
  • Liposome-stabilized oil-in-water pickering emulsion and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0046] Such as figure 1 Shown, be the preparation method flowchart of the oil-in-water Pickering emulsion that liposome is stable of the present invention, mainly comprise the following steps:

[0047] (1) Preparation of polyethylene glycol aqueous solution: mix a certain quality of polyethylene glycol with ultrapure water, stir until fully dissolved, and remove insoluble matter by centrifugal force of 5000g;

[0048] (2) Preparation of sunflower oil solution: dissolve DPPC in ethanol, remove ethanol by rotary evaporation and form a lipid film in the rotary steamer, add sunflower oil, and slowly stir until DPPC is completely dissolved;

[0049] (3) Preparation of emulsion: take the polyethylene glycol aqueous solution in step (1) and the sunflower oil solution in (2), mix evenly, then shear with a high-speed shear, and homogenize twice with a high-pressure homogenizer form an emulsion;

[0050] (4) Preparation of freeze-dried powder: After freezing the emulsion obtained in s...

Embodiment 1

[0056] (1) Preparation of polyethylene glycol aqueous solution: mix 10 g of polyethylene glycol with 90 mL of ultrapure water, stir until fully dissolved, and remove insoluble matter by centrifugation at a centrifugal force of 5000 g;

[0057] (2) Preparation of sunflower oil solution: Dissolve 25mg DPPC in ethanol, remove ethanol by rotary evaporation and form a lipid film in the rotary evaporation bottle, add 9.975g sunflower oil and stir slowly at 50°C for 2h until DPPC is completely dissolved ;

[0058] (3) Preparation of emulsion: 90 mL of polyethylene glycol aqueous solution in the above (1) and 10 g of the sunflower oil solution obtained in (2) are mixed uniformly, then sheared at 13500 rpm for 90 s with a high-speed shearing machine, and homogenized by a high-pressure homogenizer Twice, the first homogenization pressure is 35MPa, and the second homogenization pressure is 10MPa to form an emulsion;

[0059] (4) Preparation of freeze-dried powder: After freezing the emu...

Embodiment 2

[0064] (1) Preparation of polyethylene glycol aqueous solution: mix 15g polyethylene glycol with 85mL ultrapure water, stir until fully dissolved, and remove insoluble matter by centrifugation at a centrifugal force of 5000g;

[0065] (2) Preparation of sunflower oil solution: Dissolve 30mg DPPC in ethanol, remove the ethanol by rotary evaporation and form a lipid film in the rotary evaporation bottle, add 9.970g sunflower oil and stir slowly at 50°C for 2h until DPPC is completely dissolved ;

[0066] (3) Preparation of emulsion: 85 mL of polyethylene glycol aqueous solution in the above (1) and 15 g of the sunflower oil solution obtained in (2) are mixed evenly, then sheared at 15000 rpm for 90 seconds with a high-speed shearing machine, and homogenized by a high-pressure homogenizer Twice, the homogeneous pressure for the first time is 30MPa, and the homogeneous pressure for the second time is 15MPa to form an emulsion;

[0067] (4) Preparation of freeze-dried powder: Afte...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a preparation method of liposome-stabilized oil-in-water Pickering emulsion, which mainly includes the following steps: preparing polyethylene glycol aqueous solution, preparing sunflower oil solution, preparing emulsion, preparing freeze-dried powder, and preparing liposome Suspension and reconstitution steps. The oil-in-water Pickering emulsion prepared according to the method can improve the stability of the embedded sunflower oil, reduce its oxidation, and improve mouthfeel; meanwhile, the liposomes adsorbed on the surface of the oil-in-water Pickering emulsion oil droplets can also be used for Embedding other active ingredients, this emulsion is suitable for the combined utilization of various food functional factors, and is also suitable for use as a carrier of active substances in pharmaceuticals, cosmetics and agricultural supplies, and has good practical use value.

Description

technical field [0001] The invention belongs to the technical field of food, in particular to a liposome-stabilized oil-in-water Pickering emulsion and a preparation method thereof. Background technique [0002] Liposome is an artificial membrane. When amphiphilic molecules such as phospholipids and sphingolipids are dispersed in the aqueous phase, the hydrophobic tails of the molecules tend to gather together and avoid the aqueous phase, while the hydrophilic heads are exposed to the aqueous phase, forming closed vesicles with a bilayer structure, Known as liposomes, the diameter ranges from 25 to 1000nm. Liposomes can be used to transgene, or to prepare drugs, and use the characteristics of liposomes that can fuse with cell membranes to deliver drugs into cells. [0003] Oil-in-water Pickering emulsion (oil-in-water emulsion) usually has one phase in the emulsion that is water or other polar liquid, referred to as water phase, and the other phase is a non-polar liquid im...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/107A61K9/127A61K47/44A61K47/10A61K47/24A61K47/28A61K8/06A61K8/14A61K8/92A61K8/86A61K8/55A61K8/63A61Q19/00A23D7/005A23D7/04
Inventor 刘玮琳许贤康韩剑众沈萍姚怡心李可暄吴昆蓉董露
Owner ZHEJIANG GONGSHANG UNIVERSITY
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com