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Preparation and application of a ruthenium dioxide composite ovalbumin nanomaterial

A technology of ruthenium dioxide and ovalbumin, applied to wave energy or particle radiation treatment materials, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of cancer immunotherapy that have not been reported , to achieve good photodynamic effect, inhibit remote cells, and prevent tumor recurrence

Active Publication Date: 2021-08-24
GUANGXI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In recent years, the immunotherapy of cancer has made great progress, but the cancer immunotherapy of ruthenium dioxide composite nanomaterials has not been reported

Method used

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  • Preparation and application of a ruthenium dioxide composite ovalbumin nanomaterial
  • Preparation and application of a ruthenium dioxide composite ovalbumin nanomaterial
  • Preparation and application of a ruthenium dioxide composite ovalbumin nanomaterial

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Effect test

preparation Embodiment 1

[0026] 1) Weigh 0.4g ruthenium trichloride hydrate, add 10mL distilled water, stir to dissolve completely, and obtain ruthenium trichloride hydrate solution;

[0027] 2) Add ammonia water to the hydrated ruthenium trichloride solution to adjust the pH of the solution to 9, and react for 30 minutes to obtain a solution with black precipitates;

[0028] 3) Centrifuge the solution in step 2) with a centrifuge at a speed of 10,000r / min for 10 minutes; the precipitate obtained by centrifugation is washed twice with water, and then centrifuged to obtain a black precipitate;

[0029] 4) Heating the precipitate obtained in step 3) in nitrogen gas at a heating temperature of 200°C for 2 hours to obtain nano-scale ruthenium dioxide;

[0030] 5) Take 0.1 g of the ruthenium dioxide obtained in step 4) and add 0.1 g of ovalbumin into 100 mL of water and sonicate for 30 minutes to obtain a ruthenium dioxide composite ovalbumin nanomaterial.

Embodiment 2

[0032] Preparation of ruthenium dioxide composite ovalbumin nanomaterials:

[0033] 1) Weigh 0.4g ruthenium trichloride hydrate, add 10mL distilled water, stir to dissolve completely, and obtain ruthenium trichloride hydrate solution;

[0034] 2) Add ammonia water to the hydrated ruthenium trichloride solution to adjust the pH of the solution to 9, and react for 30 minutes to obtain a solution with black precipitates;

[0035] 3) Centrifuge the solution in step 2) with a centrifuge at a speed of 10,000r / min for 10 minutes; the precipitate obtained by centrifugation is washed twice with water, and then centrifuged to obtain a black precipitate;

[0036] 4) Heating the precipitate obtained in step 3) in nitrogen gas at a heating temperature of 200°C for 2 hours to obtain nano-scale ruthenium dioxide;

[0037] 5) Take 0.01 g of the ruthenium dioxide obtained in step 4), and add 0.01 g of ovalbumin into 10 mL of water and sonicate for 30 minutes to obtain a ruthenium dioxide comp...

Embodiment 3

[0039] Preparation of ruthenium dioxide composite ovalbumin nanomaterials:

[0040] 1) Weigh 0.4g ruthenium trichloride hydrate, add 10mL distilled water, stir to dissolve completely, and obtain ruthenium trichloride hydrate solution;

[0041] 2) Add ammonia water to the hydrated ruthenium trichloride solution to adjust the pH of the solution to 9, and react for 30 minutes to obtain a solution with black precipitates;

[0042] 3) Centrifuge the solution in step 2) with a centrifuge at a speed of 10,000r / min for 10 minutes; the precipitate obtained by centrifugation is washed twice with water, and then centrifuged to obtain a black precipitate;

[0043] 4) Heating the precipitate obtained in step 3) in nitrogen gas at a heating temperature of 200°C for 2 hours to obtain nano-scale ruthenium dioxide;

[0044] 5) Take 0.05 g of the ruthenium dioxide obtained in step 4), and add 0.05 g of ovalbumin into 50 mL of water and sonicate for 30 minutes to obtain a ruthenium dioxide comp...

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Abstract

The invention discloses a preparation and application of a ruthenium dioxide composite ovalbumin nanomaterial. The nanomaterial uses ruthenium trichloride hydrate and ammonia water as raw materials to synthesize nano-level ruthenium dioxide, and then compound it to egg white prepared on protein. The preparation method of the invention is simple and convenient to operate, the raw materials are cheap and easy to obtain, and the prepared nanometer material has the characteristics of low cytotoxicity, good biocompatibility and the like. Moreover, ruthenium dioxide nanomaterials have absorption in the near-infrared region, and the nanomaterials compounded on ovalbumin have good water solubility and good ability to induce anti-tumor immunity; Under this condition, active oxygen can be generated; and it can catalyze the hydrogen peroxide in the tumor to generate oxygen, which can solve the hypoxia of the tumor and is beneficial to further photodynamic therapy. The ruthenium dioxide composite ovalbumin nanometer material prepared by the invention can be used for combined photothermal photodynamic immunotherapy for cancer, and has broad application prospects in the field of cancer treatment.

Description

technical field [0001] The invention relates to a composite nano material, in particular to the preparation and application of a ruthenium dioxide composite ovalbumin nano material. Background technique [0002] Immunotherapy is a treatment method to control and eliminate tumors by restarting and maintaining the tumor-immune cycle and restoring the body's normal anti-tumor immune response. Photothermal therapy for tumors (Photothermal therapy, PTT) is a therapy that converts light energy into heat energy through a photothermal conversion agent to bring tumor tissue to a certain temperature and kill cancer cells. Photodynamic therapy (PDT) is a new cancer treatment method in which photodynamic reagents generate reactive oxygen species under laser irradiation, thereby increasing the level of reactive oxygen species in tumor tissue, and then killing cancer cells. Environment, hydrogen peroxide exists in the tumor, if hydrogen peroxide can be catalyzed to generate oxygen, it ca...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K47/64A61P35/00A61P37/04
Inventor 蒋邦平黄荣涛沈星灿罗紫兰
Owner GUANGXI NORMAL UNIV
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