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Method for producing functional organic fertilizer by using cephalosporin C filter residues

A technology of cephalosporin and organic fertilizer, applied in application, fertilization device, fertilizer mixture, etc., can solve environmental safety hazards and other problems, and achieve the effect of eliminating safety hazards, obvious economic and social benefits, and reasonable ratio

Inactive Publication Date: 2019-05-21
HEZE RUIZHI TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Cephalosporin C filter residues contain antibiotic residues. If they cannot be effectively inactivated in the production of functional organic fertilizers, or structural analogues of cephalosporin C degradation remain in the product, they will bring safety hazards to the environment.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] (1) After the fermentation of cephalosporin C, acidify and ultrafilter, collect 1 kg of cephalosporin C filter residue after ultrafiltration; sampling test shows that the water content is 84.6%, the residual cephalosporin C is 684ug / ml, and the protein content is 41.7% ( Based on dry matter), the pH is 3.14;

[0027] (2) Add 222.3g of 36.5% concentrated hydrochloric acid to the filter residue, and hydrolyze it in a water bath at about 98°C for 22 hours;

[0028] (3) Sampling detection, potentiometric titration method to detect amino acid content of 4.0%, protein conversion rate = amino acid content of hydrolyzate / theoretical protein content of hydrolyzate × 100% = 76.4%; HPLC detection of cephalosporin C¸7-aminocephalosporin acid (7-ACA)¸ deacetyl-7-aminocephalosporanic acid (D-7-ACA), the detected amount was 0;

[0029] (4) Add ammonia water to the hydrolyzate to adjust the pH to 6.24, without further high-temperature inactivation of cephalosporin C, and directly redu...

Embodiment 2

[0032] (1) According to the operation method from step (1) to step (5) in Example 1, add 32.7% concentrated hydrochloric acid of cephalosporin C filter residue, hydrolyze at about 98°C for 45 hours, and neutralize with ammonia water until the pH is 6.75;

[0033] (2) Detection, protein conversion rate 96.4%, amino acid content 4.17%;

[0034] (3) HPLC detection of cephalosporin C, 7-aminocephalosporanic acid (7-ACA) and deacetyl-7-aminocephalosporanic acid (D-7-ACA), the detection amount was 0;

[0035] (4) Take 1200g of the above-mentioned functional organic fertilizer I and concentrate it with a rotary evaporator at a concentration temperature of about 65°C to obtain 426.8g of a concentrated solution with an amino acid content of 11.72%;

[0036] (5) Add 36.4g of anhydrous calcium chloride to the concentrated solution, filter it with a 120-mesh filter after dissolving, collect 413.3g of the filtrate, collect the filter residue and use it as a raw material for solid organic f...

Embodiment 3

[0039] (1) Take 1200g of the functional organic fertilizer I obtained in Example 1, and concentrate it in vacuum with a rotary evaporator at a concentration temperature of about 65°C, and concentrate it to about 40% of the original mass to obtain 468.4g of a concentrated solution;

[0040] (2) The concentrated solution is dried in a vacuum drying oven at a drying temperature of about 65°C and a vacuum degree of ≥0.095MPa to obtain 262.4g of a solid product, which is the functional organic fertilizer III of the present invention.

[0041] The product content was tested, and the water content was 9.84%, the total amino acid content was 16.0%, and the organic matter content was 51.0%.

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Abstract

The invention relates to the technical field of fertilizer production, and particularly discloses a method for producing a functional organic fertilizer by using cephalosporin C filter residues. Withthe cephalosporin C filter residues as a raw material, the method for producing the functional organic fertilizer by using the cephalosporin C filter residues is characterized by comprising the stepsof adding strong acid to the raw material for hydrolysis to obtain a hydrolyzate; adding alkali to the hydrolyzate for neutralization, and conducting heat preservation to obtain an organic fertilizermasterbatch; conducting vacuum concentration on the organic fertilizer masterbatch, adding medium and trace elements, and through fine filtration, obtaining a filtrate, namely the functional organic fertilizer product. By means of the method, the treatment problem of the cephalosporin C filter residues is thoroughly solved, the process is simple, the cost is low, the product functionality is high,the market prospect is good, and the method has good social and economic benefits and has industrial popularization prospects.

Description

(1) Technical field [0001] The invention relates to the technical field of fertilizer production, in particular to a method for producing functional organic fertilizer by using cephalosporin C filter residue. (2) Background technology [0002] Cephalosporins account for about 40% of the market share of anti-infective drugs. The two main raw material cores used in their production - 7-aminocephalosporanic acid (7-ACA) and deacetyl-7-aminocephalosporanic acid (D-7-ACA) is produced by chemical or enzymatic cleavage of cephalosporin C. Cephalosporin C is produced through biological fermentation of Cephalosporin acremonium. During the production process, a large amount of cephalosporin C filter residue is produced, and its components mainly include mycelium, culture medium residue, and organic metabolic waste. The output of cephalosporin C filter residue reached about 500,000 tons. [0003] Cephalosporin C filter residue contains cephalosporin C residue, which belongs to antibi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C05G3/04C05G3/80
Inventor 于海勤吴桂平乔久生孟中英李辉
Owner HEZE RUIZHI TECH DEV
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