Method for synthesizing 1, 8-diazabicycle

Abstract

The invention provides a synthesis method of 1, 8-diazabicycle. According to the technical scheme, a synthesis route of DBU is innovatively designed. Specifically, the method comprises the steps of firstly, reacting epsilon caprolactam, acrylonitrile and hydroquinone to generate N-(beta-cyanoethyl)-epsilon caprolactam, on the basis, reacting the N-(beta-cyanoethyl)-epsilon caprolactam with p-toluenesulfonic acid under a catalytic condition, then carrying out ice bath, reacting the N-(beta-cyanoethyl)-epsilon caprolactam with benzyl chloride under the protection of nitrogen, reacting the obtained product with sodium perborate by taking EDTA as a catalyst, and mixing a reaction product with 3-phenylpropionic acid and then reacting the mixture with 4-nitrochlorobenzyl to obtain the product; filtering the reaction product, extracting the filtrate with ethyl acetate after filtering, performing solid-liquid separation, merging solid phases, and drying the solid phases under reduced pressureto obtain the final product. According to the method, a brand-new synthetic route is adopted, the reaction condition is mild, the cost of raw materials is low, and the method has quite high popularization prospect.

Description

technical field [0001] The invention relates to the technical field of chemical synthesis, in particular to a synthesis method of 1,8-diazabicyclo. Background technique [0002] 1,8-Diazabicyclo(5,4,0)-7-undecene (DBU) is mainly used as a catalyst for the production of polyurethane and other chemicals, such as ammonia and dichloroethane in its In the presence of the reaction to generate piperazine, it is an excellent dehydrating agent, epoxy resin hardener, antirust agent, and can also be prepared as a high-grade corrosion inhibitor. Currently widely used in the production of cephalosporin semi-synthetic antibiotics. Also used in organic synthesis reactions and semi-synthetic antibiotics. Catalyst for the production of polyurethane and other chemical products, such as the reaction of ammonia and dichloroethane to generate piperazine in its presence, is an excellent dehydrating agent, epoxy resin hardener, rust inhibitor, can Formulated advanced corrosion inhibitors. Wide...

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Problems solved by technology

[0004] The present invention aims at the technical defects of the prior art, and provides a synthesis method of 1,8-diazabicyclo, so as to solve the technical problems of harsh reaction conditions and low yield in the conventional synthesis method of DBU in the prior art

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