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Skin external preparation containing flurbiprofen

A technology of flurbiprofen and external preparations, applied in the field of poultice containing flurbiprofen, can solve problems such as poor hydrogel adhesion, and achieve the effect of solving poor adhesion

Active Publication Date: 2019-05-28
BEIJING TIDE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, with the progress of research, the research on the transdermal permeability of hydrogel plaster drug stabilizer is getting more and more in-depth, and the stability and transdermal property of hydrogel plaster have also made some progress, but it is troubled by the majority of patients. The problem of poor adhesion of hydrogels has not been effectively solved

Method used

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  • Skin external preparation containing flurbiprofen
  • Skin external preparation containing flurbiprofen
  • Skin external preparation containing flurbiprofen

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1 Prescription Screening

[0025] Table 1. Sample formulation1

[0026]

[0027] Preparation:

[0028] Dissolve the prescribed amount of sodium carboxymethylcellulose in glycerin and partially purified water to obtain component A; dissolve the prescribed amount of gelatin in partially purified water, heat it after the expansion is complete, and stir until it becomes a transparent colloid to obtain the component A. Part B; dissolve the prescribed amount of polyacrylic acid-polyacrylic acid copolymer (NP700) and aluminum glycolate in glycerin, and stir evenly to obtain component C; mix the prescribed amount of flurbiprofen and crotamiton evenly , add L-menthol, isopropyl myristate (IPM), Tween 80, sorbitan sesquioleate, polyvinyl alcohol (PVA), polyacrylic acid and mix well to form component D; Disperse disodium acid and kaolin in purified water respectively, add components A, B, and C, fully knead, and disperse evenly, then add component D, use tartaric acid...

Embodiment 2

[0054] The research of embodiment 2 cross-linking agent

[0055] The present invention has carried out further research on the cross-linking agent in the prescription, and prescription is as table 3 below, and preparation method is as embodiment 1:

[0056] Table 3. Formulation Studies for Crosslinkers

[0057]

[0058] Determination of the above prescription and adhesion ( figure 2 ) results show that when aluminum hydroxide or aluminum glycolate is used as the crosslinking agent, the adhesion of babu plaster can achieve a satisfactory effect, especially when aluminum glycolate is used, the adhesion effect is the best. The consumption of joint agent is less than 0.2 part, and when greater than 4.0 part, all can not prepare the Babu ointment that meets the standard.

Embodiment 3

[0059] The research of embodiment 3 filler

[0060] The present invention has carried out further research on the filling agent in the prescription, and the prescription is as in Table 3, and the preparation method is as in Example 1:

[0061] Table 4. Formulation Studies for Fillers

[0062]

[0063] Composed of the above prescription and the results of the adhesion test ( image 3 ) shows that both titanium dioxide and kaolin as fillers can effectively improve the adhesion, but their dosage must be strictly controlled. When the dosage exceeds 50 parts, the paste will be too hard to achieve effective coating. At 2.5 parts, the paste is soft and there will be residue when used.

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PUM

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Abstract

The invention discloses a skin external preparation containing flurbiprofen. The preparation is formed by a back lining layer, a drug storage library matrix layer and a protecting film, wherein the preparation comprises 1-10 parts of the flurbiprofen, 30-100 parts of a gel skeleton component, 0.2-3.5 parts of a cross-linking agent, 1-4 parts of a cross-lining regulator, 1-15 parts of an accelerant, 5.0-52.5 parts of a filler, 1-10 parts of a bacteriostatic agent, 10-50 parts of a solubilizer and 40-60 parts of a thickener. The flurbiprofen skin external preparation provided by the invention issafe, effective, stimulation-free, good in adhesion, and not easy to fall off.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to an external skin preparation containing flurbiprofen, in particular to a poultice containing flurbiprofen. Background technique [0002] Acute and chronic orthopedic pain is the most common symptom of orthopedic diseases, with a high incidence and great harm. Oral non-steroidal anti-inflammatory drugs (NSAIDS) are mostly used for treatment. Due to the short duration of drug efficacy of oral preparations, repeated administration is prone to produce "peak and valley" phenomenon of blood drug concentration, resulting in poor curative effect or toxic side effects. And serious gastrointestinal side effects. Therefore, clinically, external application of NSAIDS has become the first choice of doctors. Babu ointment is a transdermal external preparation based on a hydrophilic polymer material. It has the advantages of large drug loading, water retention, moisturizing, good air ...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/192A61K47/32A61K47/38A61K47/18A61K47/36A61P29/00
CPCA61K9/7023A61K47/32A61K31/192A61K31/167A61P19/08A61P29/00A61K2300/00
Inventor 卢迪吴昀蒲晓蕾高莹
Owner BEIJING TIDE PHARMA
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