Traditional Chinese medicine composition for treating diabetic nephropathy and preparation method and application thereof

A technology of diabetic nephropathy and its composition, applied in the field of pharmacy, can solve the problems of progression to uremia, limited curative effect, deterioration of renal function, etc., and achieve the effects of reducing proteinuria, no adverse reactions, and reducing podocyte damage

Inactive Publication Date: 2019-05-31
NANJING DRUM TOWER HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In recent years, the results of large international evidence-based medical trials have shown that angiotensin-converting enzyme inhibitors and angiotensin II receptor antagonists can reduce proteinuria in patients with DN, but the efficacy is limited, especially for patients with stage III DN. Once proteinuria is not effectively controlled, the renal function will deteriorate rapidly and progress to uremia

Method used

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  • Traditional Chinese medicine composition for treating diabetic nephropathy and preparation method and application thereof
  • Traditional Chinese medicine composition for treating diabetic nephropathy and preparation method and application thereof
  • Traditional Chinese medicine composition for treating diabetic nephropathy and preparation method and application thereof

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Effect test

Embodiment 1

[0023] The preparation of embodiment 1 Chinese medicine composition pill of the present invention

[0024] Take 60g of golden cherry, 60g of gorgon, 60g of raspberry, 60g of dodder, 15g of tripterygium wilfordii, and 60g of motherwort.

[0025] Take each component and add 8 times the amount of water, take 15g of Tripterygium wilfordii and add water to boil for 15 minutes, then add 60g of golden cherry, 60g of gorgon, 60g of raspberry, 60g of dodder, 60g of motherwort, and boil for 2-3 times. For 1-3 hours each time, combine the decoction, concentrate, heat polyoxyethylene monostearate and glyceryl behenate in a water bath, add colloidal silicon dioxide while stirring, continue stirring, and slowly add Chinese medicine for extraction material, mixed evenly to obtain a melt. Drop the melt into the simethicone condensate, condense into pills, wash the pills with simethicone, and then wipe off the simethicone on the surface of the pills to prepare pills.

Embodiment 2

[0026] The preparation of embodiment 2 Chinese medicine composition tablet of the present invention

[0027] Take 40g of golden cherry, 40g of gorgon, 40g of raspberry, 40g of dodder, 10g of tripterygium wilfordii, and 40g of motherwort.

[0028]Take each component and add 12 times the amount of water, take 10g of Tripterygium wilfordii, add water and boil for 15 minutes, then add 40g of golden cherry, 40g of gorgon, 40g of raspberry, 40g of dodder, 40g of motherwort, add water and then boil (the time is the same as above) , combined decoction, concentrated to obtain extract, dried, crushed to obtain dry powder, added 1.4 times the amount of dextrin, mixed evenly, added an appropriate amount of 75% ethanol, stood still for 12-24 hours, filtered, recovered ethanol from the filtrate, and prepared Granules, dried, sieved, and then added with an appropriate amount of glidant, compressed into tablets to make tablets.

Embodiment 3

[0029] The preparation of embodiment 3 Chinese medicine composition granules of the present invention

[0030] Take 30g of golden cherry, 30g of gorgon, 30g of raspberry, 30g of dodder, 10g of tripterygium wilfordii, and 30g of motherwort.

[0031] Take each component and add 12 times the amount of water, take 10g of Tripterygium wilfordii, add water and boil for 15 minutes, then add 30g of golden cherry, 30g of gorgon, 30g of raspberry, 30g of dodder, 30g of motherwort, add water and then boil (the time is the same as above) , combined decoction, concentrated to obtain extract, dried, crushed to obtain dry powder, added 1.4 times the amount of dextrin, mixed, added 75% ethanol in an appropriate amount, granulated, dried, and made into granules.

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Abstract

The invention discloses a traditional Chinese medicine composition for treating diabetic nephropathy. The traditional Chinese medicine composition is prepared from, by weight, 15-60 parts of cherokeerose fruits, 15-60 parts of gorgon fruits, 15-60 parts of fructus rubi, 15-60 parts of the seeds of Chinese dodder, 5-15 parts of tripterygium glycosides and 15-60 parts of herba leonuri. The invention further provides a preparation method of the traditional Chinese medicine composition and application of the traditional Chinese medicine composition in treating proteinuria of patients who suffer from the diabetic nephropathy. The traditional Chinese medicine composition is based on experience of famous veteran doctors of traditional Chinese medicine in Jiangsu province, the traditional Chinesemedicine composition has the functions of tonifying the kidney to arrest spontaneous emission and clearing and dispersing blood stasis, and is used for treating the proteinuria of the patients who suffer from early and mid-term diabetic nephropathy. Through clinical pharmacodynamic experiments, it is shown that the traditional Chinese medicine composition can reduce the proteinuria of the patients who suffer from diabetic nephropathy III, and there are no adverse reactions in the experiment process; through in-vivo pharmacological experiments, it is shown that the traditional Chinese medicinecomposition can reduce podocyte injury associated with diabetic nephropathy inflammation, the structures and the functions of podocytes are improved, and the proteinuria is reduced.

Description

technical field [0001] The invention belongs to pharmaceutical technology, and in particular relates to a traditional Chinese medicine composition for treating diabetic nephropathy proteinuria, a preparation method and application thereof. Background technique [0002] At present, the high incidence of diabetes in my country has become a public health problem that affects national economic and social development and seriously endangers national health. Among them, diabetic nephropathy (diabetic nephropathy, DN), as the most common clinical complication, is an important cause of diabetes patients progressing to uremia. Studies have shown that proteinuria is not only the main clinical manifestation of most early and mid-stage DN patients, but also an independent risk factor for the deterioration of renal function. Therefore, clinically, controlling proteinuria is the basic treatment to delay the progression of DN. Studies at home and abroad have shown that stage III (Danish ...

Claims

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Application Information

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IPC IPC(8): A61K36/738A61P3/10A61P13/12
Inventor 万毅刚涂玥吴薇刘莹露曹东维
Owner NANJING DRUM TOWER HOSPITAL
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