Self-healing injectable hydrogel, preparation method and application thereof

A hydrogel, self-healing technology, used in applications, surgical adhesives, medical science, etc., can solve problems such as body fluid leakage, adhesive damage, wound infection, etc., to prevent leakage, low cost, and method. simple effect

Inactive Publication Date: 2019-05-31
佛山市华健科创科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Since the adhesive may be damaged under the force of the wound,

Method used

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  • Self-healing injectable hydrogel, preparation method and application thereof
  • Self-healing injectable hydrogel, preparation method and application thereof
  • Self-healing injectable hydrogel, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] (1) Preparation of aldylated chondroitin sulfate:

[0038] Weighing 5.00g chondroitin sulfate A sodium salt is dissolved in 80ml deionized water to obtain chondroitin sulfate solution; weigh 1.28g sodium periodate (NaIO 4 ) was dissolved in 20ml of deionized water to obtain a sodium periodate solution; the sodium periodate solution was slowly added dropwise to the chondroitin sulfate solution under the condition of avoiding light, the reaction temperature was 20°C, and the reaction time was 6h; after the reaction , add 3g of borax, dialyze with the dialysis bag of Mw=3500 for 2 days, change the water every 6h; then pour the product into a flat glass dish, freeze and freeze-dry at -80°C to obtain the chondroitin sulfate of aldehydization ( OCS);

[0039] (2) Preparation of aldylated chondroitin sulfate-gelatin hydrogel:

[0040] Prepare 15% w / v formylated chondroitin sulfate solution (100 mL of formylated chondroitin sulfate solution contains 15 g of formylated chondro...

Embodiment 2

[0052] (1) The preparation of formylated chondroitin sulfate is the same as step (1) in Example 1

[0053] (2) Preparation of aldylated chondroitin sulfate-gelatin hydrogel:

[0054] Use PBS buffer to prepare 15% w / v formylated chondroitin sulfate and 22.5% w / v gelatin solution (gelatin solution is prepared by dissolving at 50°C); mix the two solutions in equal volumes to generate a Schiff base Reaction, the mixing reaction temperature is 37°C, and the mixing time is 20s to obtain the Gel-OCS hydrogel pre-polymerization liquid;

[0055] (3) Formylated chondroitin sulfate-gelatin hydrogel / Fe 3+ The preparation of the hydrogel was the same as (3) in Example 1.

[0056] Gel-OCS / Fe in this embodiment 3+ The rheology and adhesion tests of the hydrogel were the same as in Example 1.

[0057] Gel-OCS / Fe 3+ The storage modulus of the hydrogel is 986Pa, and the adhesion force is 3.03N / cm 2 (Pigskin test adhesion).

Embodiment 3

[0059] (1) the preparation of aldylated chondroitin sulfate is the same as step (1) in Example 1;

[0060] (2) Preparation of aldylated chondroitin sulfate-gelatin hydrogel:

[0061] Use PBS buffer to prepare 10% w / v aldylated chondroitin sulfate solution and 20% w / v gelatin solution, and dissolve the gelatin solution at 50°C; mix the two solutions in equal volumes to generate a Schiff base Reaction, the mixing reaction temperature is 37°C, and the mixing time is 20s to obtain the Gel-OCS hydrogel pre-polymerization liquid;

[0062] (3) Formylated chondroitin sulfate-gelatin hydrogel / Fe 3+ The preparation of the hydrogel was the same as (3) in Example 1.

[0063] Gel-OCS / Fe in this embodiment 3+ The rheology and adhesion test of hydrogel are identical with embodiment 1

[0064] Gel-OCS / Fe 3+ The storage modulus of the hydrogel is 679Pa, and the adhesion force is 2.43N / cm 2 .

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Abstract

The invention belongs to the technical field of hydrogel adhesives, and discloses a self-healing injectable hydrogel, a preparation method and an application thereof. The method includes the followingsteps: (1) reacting chondroitin sulfate or chondroitin sulfate salt with an oxidant in water for subsequent treatment to obtain aldehyde chondroitin sulfate; (2) mixing the aldehyde chondroitin sulfate and gelatin in a solvent to obtain a hydrogel prepolymer solution; (3) mixing the hydrogel prepolymer solution with an Fe3+ solution to obtain the self-healing injectable hydrogel. According to themethod, through the combined use of chondroitin sulfate, gelatin and Fe3+, the prepared hydrogel has good biocompatibility, strong adhesiveness, rapid self-healing capability and injectability. The self-healing injectable hydrogel is applied in bio-adhesives, especially in medical bio-adhesives.

Description

technical field [0001] The invention belongs to the technical field of hydrogel adhesives, in particular to a self-healing and injectable hydrogel and its preparation method and application. The hydrogel is used in bioadhesives, especially medical hydrogel adhesives. Background technique [0002] With the continuous advancement of medicine, modern clinics have higher and higher requirements for surgical techniques and auxiliary materials. For a long time, the most widely used method for suturing wounds clinically is to suture wounds with materials such as sutures or rivets. Although this method can suture the wound well and has certain mechanical strength, it will increase the patient's pain and leave scars after recovery. The concept of modern medicine is to minimize the suffering of patients, recover the patient in the shortest time, restore the function to the greatest extent and restore the appearance perfectly. Therefore, this promotes the continuous development of m...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08L89/00C08L5/08C08B37/08A61L24/10A61L24/08A61L24/02A61L24/00
Inventor 宁成云代聪张珂嘉周正难
Owner 佛山市华健科创科技有限公司
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