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Applications of rhizoma polygoni cuspidati and rhizoma curcumae longae and active substance thereof in treatment of interstitial lung disease

A technology of knotweed and turmeric, applied in the field of application of knotweed and turmeric and their active substances in the treatment of interstitial lung disease

Pending Publication Date: 2019-06-04
孟凤仙 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In the prior art, for the inhibitory effect of polydatin on TGF-β1-induced EMT in human lung A549 cells cultured in vitro, see "Chinese Journal of Integrated Traditional Chinese and Western Medicine, Issue 4, Volume 36, April 2016", which only involves the in vitro Cultured human lung A549 cells for detection of fibrosis-related factors

Method used

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  • Applications of rhizoma polygoni cuspidati and rhizoma curcumae longae and active substance thereof in treatment of interstitial lung disease
  • Applications of rhizoma polygoni cuspidati and rhizoma curcumae longae and active substance thereof in treatment of interstitial lung disease
  • Applications of rhizoma polygoni cuspidati and rhizoma curcumae longae and active substance thereof in treatment of interstitial lung disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0038] Experimental materials and methods

[0039] 1. Test animals:

[0040] 150 SPF-grade male C57 / BL6 mice, 4 weeks old, weighing 20±2g, were purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd. (permit number: SCXK (Beijing) 2016-0006).

[0041] 2. Test drug:

[0042] The prescription is composed of knotweed and turmeric, provided by Dongfang Hospital of Beijing University of Traditional Chinese Medicine; polydatin and curcumin monomer (batch number: H-012) were purchased from Chengdu Ruifensi Biotechnology Co., Ltd.; prednisone acetate tablets 5mg / tablet (Lot number: 1709109), purchased from Tianjin Lisheng Pharmaceutical Co., Ltd.; bleomycin hydrochloride for injection, purchased from Nippon Kayaku Co., Ltd.

[0043] 3. Drug dosage:

[0044] For prednisone acetate tablets, the daily dosage for humans is 20-60mg / 60kg / d, which is calculated as 60mg / 60kg / d during the test. During the test, the dosage converted into mice was 10 mg / kg / d.

[0045...

Embodiment 1

[0052] Example 1: Results after 4 weeks of administration

[0053] The result of naked eye observation:

[0054] In the normal control group (normal saline 50μL), the lung tissue of the 6 mice submitted for inspection had no obvious color change, and the structure was normal;

[0055] In the model control group (normal saline 50 μL), most of the 6 mice submitted for examination had gray lesions of varying degrees on the surface of the lung tissue, which were more diffuse, and no exudation was seen on the surface;

[0056] Positive control drug group: 6 mice submitted for inspection had localized mild gray lesions on the lung surface;

[0057] Polydatin and curcumin composition group (ingredient composition group): high, medium and low three different dosage groups (high dosage group 200mg / kg / d; middle dosage group 100mg / kg / d; low dosage group 50mg / kg / d) There are different degrees of localized mild gray lesions on the lung surface of the mice, compared with the model contro...

Embodiment 2

[0093] Embodiment 2: the result after administration 8 weeks

[0094] The result of naked eye observation:

[0095] Normal control group (normal saline 50 μL): The lung tissue surface of the 6 mice submitted for inspection showed no hyperemia, stasis, tissue enlargement, edema, gray change, and normal structure;

[0096] Model control group (normal saline 50μL): The lung tissue of the 6 mice submitted for examination had different degrees of blood stasis and swelling, and there was a large area of ​​gray change on the upper surface, and no obvious lesions were found on the quilt;

[0097] Positive control drug group: the blood stasis, gray discoloration and swelling in the lung tissue of 6 mice were alleviated to varying degrees;

[0098]Polydatin and curcumin composition group (ingredient composition group): high, medium and low three different dosage groups (high dosage group 200mg / kg / d; middle dosage group 100mg / kg / d; low dosage group 50mg / kg / d) 6 mice in each group, a t...

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Abstract

The present invention relates to a rhizoma polygoni cuspidati and rhizoma curcumae longae formula, and an application thereof in preparing a drug for treating interstitial lung disease, and also relates to a composition of the rhizoma polygoni cuspidati and rhizoma curcumae longae, and an application thereof in preparing a drug for treating the interstitial lung disease.

Description

technical field [0001] The invention relates to the application of Polygonum cuspidatum and turmeric prescription in treating interstitial lung disease, and also relates to the application of polydatin and curcumin composition in treating interstitial lung disease. Background technique [0002] Interstitial lung disease (ILD) is based on diffuse lung parenchyma, alveolar inflammation and interstitial fibrosis as pathological basic lesions, and is characterized by active dyspnea, diffuse infiltrating shadows on chest X-ray, restrictive ventilatory disorder, diffuse (DLCO ) Reduced function and hypoxemia are the general term for clinical-pathological entities composed of different kinds of disease groups with clinical manifestations. The main manifestations of ILD are inflammatory changes involving membranous and respiratory bronchioles; brown pigmented macrophages are characteristic; the etiology is mostly unknown, and the pathogenic factors that initiate ILD are usually toxi...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61K31/7034A61K31/12A61P11/00
Inventor 孟风仙崔晓兰
Owner 孟凤仙
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