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Use of surface-reacted calcium carbonate for preparing supersaturated aqueous systems

A surface-reactive, water-based system technology, applied in the direction of applications, botany equipment and methods, medical preparations containing active ingredients, etc., can solve poor usability, active ingredients or corresponding formulation efficacy active ingredient bioavailability limitations, low Solubility etc.

Inactive Publication Date: 2019-06-04
OMYA INT AG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the efficacy of the active ingredient or the corresponding formulation is often limited by the bioavailability of the active ingredient itself
In many cases, the active ingredients have low solubility in water, so that under the conditions under which they are applied, for example under physiological conditions of the human or animal body or under open field conditions in the case of insecticides or plant nutrients, their Only poor usability in the target system

Method used

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  • Use of surface-reacted calcium carbonate for preparing supersaturated aqueous systems
  • Use of surface-reacted calcium carbonate for preparing supersaturated aqueous systems
  • Use of surface-reacted calcium carbonate for preparing supersaturated aqueous systems

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0240] Embodiment 1: preparation through surface reaction calcium carbonate

[0241]In a mixing vessel, 330 liters of an aqueous suspension of calcium carbonate-containing minerals were prepared by adjusting the solids content of ground limestone calcium carbonate from Omya SAS, Orgon having a median particle size on a weight basis of 1.3 μm as determined by sedimentation , such that a solids content of 10% by weight, based on the total weight of the aqueous suspension, is obtained.

[0242] While mixing the suspension at a mixer tip speed of 12.7 m / s, 10.6 kg of an aqueous solution containing 30% by weight of phosphoric acid, based on the total weight of the aqueous solution, were added to the suspension over a period of 12 minutes at a temperature of 70°C middle. After acid addition, the slurry was stirred for an additional 5 minutes before it was removed from the container and dried. During acid treatment, carbon dioxide is formed in situ in the aqueous suspension.

[...

Embodiment 2

[0244] Embodiment 2: the supersaturated solution of chloramphenicol

[0245] load:

[0246] 100 g of the surface-reacted calcium carbonate (d 50 (Volume) ≈7μm, d 98 (volume)≈16μm, SSA≈55m 2 / g) Shake at 300 rpm using a Heidolph Uni 2010 orbital shaker in a 11 Il Ischia flask. A 133 g / ml stock solution of chloramphenicol (dried, purchased from Merck, #1.02366.0050) in absolute ethanol was added dropwise at a rate of 1.5 drops / sec using a buret until the SRCC powder was loaded with 8.65% w / w of chloramphenicol. The samples were dried at room temperature. The percent loading and absence of ethanol was confirmed by TGA.

[0247] Calibration curve:

[0248] The following standard solutions of chloramphenicol in water were prepared and analyzed by UV-VIS: 0.013 mg / ml, 0.083 mg / ml, 0.113 mg / ml, 0.167 mg / ml and 0.333 mg / ml. The absorbance of each 3 μl standard was measured at 280nm in a Nanodrop 2000c device and used as a reference to determine a calibration curve of "mg / ml ...

Embodiment 3

[0255] Example 3: Supersaturated solution of 2-phenylphenol

[0256] load:

[0257] 50 g of surface-reacted calcium carbonate (d 50 (Volume) ≈7μm, d 98 (volume)≈16μm, SSA≈55m 2 / g) Shake at 300 rpm using a Heidolph Uni 2010 orbital shaker in a 11 Il Ischia flask. Using a burette, a stock solution of 75% w / w 2-phenylphenol (purchased from Lanxess, Preventol O Extra) in absolute ethanol was added dropwise at a rate of 1.5 drops / s until the SRCC powder was loaded with 17.2% w / w 2-Phenylphenol of w. The samples were dried at room temperature. The percent loading and absence of ethanol was confirmed by TGA.

[0258] Calibration curve:

[0259] Prepare the following standard solutions of 2-phenylphenol in water and analyze by UV-VIS: 0.025mg / ml, 0.05mg / ml, 0.1mg / ml, 0.2mg / ml, 0.4mg / ml, 0.6mg / ml and 0.8mg / ml. The absorbance of each 3 μl standard was measured at 283 nm in a Nanodrop 2000c device and used as a reference to determine a calibration curve of "mg / ml 2-phenylphenol...

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Abstract

The present invention relates to the use of a loaded particulate carrier comprising surface-reacted calcium carbonate loaded with an active ingredient, characterized in that the loaded particulate carrier is used for preparing an aqueous system comprising said active ingredient in dissolved form, wherein the mass concentration of dissolved active ingredient in said aqueous system corresponds to asupersaturated state. The surface-reacted calcium carbonate is a reaction product of calcium carbonate treated with CO2 and one or more H3O+ ion donors, wherein the CO2 is formed in situ by the H3O+ ion donors treatment and / or is supplied from an external source.

Description

technical field [0001] The present invention relates to the use of surface-reacted calcium carbonate as a particulate carrier for the preparation of supersaturated aqueous systems comprising active ingredients in dissolved state with low water solubility. Background technique [0002] Active ingredients are biologically active substances that are responsible for the efficacy of most human or veterinary medicines and pesticides. [0003] Significant efforts have been made to increase the efficacy of active ingredients or of the corresponding formulations. In addition to synthesizing new active ingredients, the provision of synergistic compositions represents another direction to enhance the efficacy of a given active ingredient, meaning that the combination of two or more such substances produces an effect greater than that produced by these substances. resulting in the sum of their respective effects. In addition to this, the combination of two or more active ingredients m...

Claims

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Application Information

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IPC IPC(8): A01N25/00A01N25/08A01N25/26A01N59/00A61K9/46A61K9/14A61K31/165
CPCA01N25/00A01N25/08A01N25/26A01N59/00A61K9/0007A61K9/14A61K9/143A61K31/165A01N31/08A01N37/20
Inventor C·迪亚斯基哈诺M·申克尔J·舍尔科普夫P·A·C·甘恩
Owner OMYA INT AG
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