A kind of enteric coating of dirithromycin enteric-coated tablet, its preparation method and a kind of dirithromycin enteric-coated tablet
A technology of dirithromycin tablets and dirithromycin is applied in the directions of pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc. The level of enteric-coated preparations is uneven, the bioavailability and oral characteristics are reduced, etc., to achieve uniform release, improved stability, and safe preparation methods.
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Embodiment 1
[0050] 250mg dirithromycin enteric-coated tablet
[0051] Dirithromycin Tablets 745mg
[0052] Dirithromycin Isolation Coat 767.35mg
[0053] Enteric layer
[0054]
[0055]
[0056] The preparation method of dirithromycin enteric-coated tablet is as follows:
[0057] (a) take by weighing the barrier coat coating powder according to the formula, add the barrier coat coating powder to the 80% ethanol solution, stir and shear at a high speed to a dispersed state to obtain coating solution I;
[0058] (b) preheating the dirithromycin tablet in a coating machine, 2-4 rpm, preheating at 40°C, and uniformly coating the surface of the dirithromycin tablet with the coating solution I, The coating liquid is uniformly grown and dried on the surface of the tablet, and the final drying is sufficient to form dirithromycin isolation-coated tablets;
[0059] (c) placing the dirithromycin barrier coat tablet in a coating machine and continuing to dry, drying at 2-8 rev / min at 40° C....
Embodiment 2
[0061] 250mg dirithromycin enteric-coated tablet
[0062] Dirithromycin Tablets 745mg
[0063] Dirithromycin Isolation Coat 774.8mg
[0064] Enteric layer
[0065]
[0066] The steps are the same as in Example 1.
Embodiment 3
[0068] 250mg dirithromycin enteric-coated tablet
[0069] Dirithromycin Tablets 745mg
[0070] Dirithromycin Isolation Coat 767.35mg
[0071] Enteric layer
[0072]
[0073] The steps are the same as in Example 1.
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