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A kind of preparation method of Gansu dispersible tablet

A Gansu dispersible tablet and dispersible tablet technology, which is applied in the field of dispersible tablets, can solve the problems of insufficiently uniform material mixing, poor dispersion uniformity, and long disintegration time of dispersible tablets, and achieve short disintegration time, good dispersion uniformity, and high efficacy. strong effect

Active Publication Date: 2021-10-26
YUNNAN JINWUHEI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the deficiencies in the prior art, the present invention provides a preparation method of Gansu dispersible tablets, which solves the problem of long disintegration time, poor dispersion uniformity and insufficient material mixing of the dispersible tablets produced by the traditional preparation method of Gansu dispersible tablets. uniform problem

Method used

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  • A kind of preparation method of Gansu dispersible tablet
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  • A kind of preparation method of Gansu dispersible tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] The concrete preparation method step of Gansu dispersible tablet is set as:

[0021] Step S1: Mix soft materials, take the extract powder extracted from root vegetables and add it to the mixing drum, take a certain amount of filler and add it to the mixing drum, mix with the agitator for 3 minutes, take a certain amount of talcum powder and add it to the mixing drum Inside, mix with a mixer for 3 minutes, take a certain amount of primary disintegrant and add it into the mixing drum, mix it with the mixer for 3 minutes, take a certain amount of binder, add it into the mixing drum, and mix it with the mixer for 3 minutes to make a suitable The soft material, the filler is set to a mixture of manna microcrystalline cellulose, compressible starch and lactose, the ratio of manna microcrystalline cellulose, compressible starch and lactose is set to 1:2:1, and the primary disintegrant is set It is a mixture of cross-linked polyvinylpyrrolidone, sodium carboxymethyl starch and ...

Embodiment 2

[0031] The concrete preparation method step of Gansu dispersible tablet is set as:

[0032] Step S1: Mix soft materials, take the extract powder extracted from root vegetables and add it to the mixing drum, take a certain amount of filler and add it to the mixing drum, mix with the agitator for 3 minutes, take a certain amount of talcum powder and add it to the mixing drum Inside, mix with a mixer for 3 minutes, take a certain amount of primary disintegrant and add it into the mixing drum, mix it with the mixer for 3 minutes, take a certain amount of binder, add it into the mixing drum, and mix it with the mixer for 3 minutes to make a suitable The soft material, the filler is set to a mixture of manna microcrystalline cellulose, compressible starch and lactose, the ratio of manna microcrystalline cellulose, compressible starch and lactose is set to 1:2:1, and the primary disintegrant is set It is a mixture of cross-linked polyvinylpyrrolidone, sodium carboxymethyl starch and ...

Embodiment 3

[0042] The concrete preparation method step of Gansu dispersible tablet is set as:

[0043] Step S1: Mix soft materials, take the extract powder extracted from root vegetables and add it to the mixing drum, take a certain amount of filler and add it to the mixing drum, mix with the agitator for 3 minutes, take a certain amount of talcum powder and add it to the mixing drum Inside, mix with a mixer for 3 minutes, take a certain amount of binder and add it to the mixing drum, and mix with a mixer for 3 minutes to make a suitable soft material. The filler is set to manna microcrystalline cellulose, compressible starch and lactose The mixture of manna microcrystalline cellulose, compressible starch and lactose is set to 1:2:1, and the binder is set to polyvinylpyrrolidone solution, which is prepared by dissolving polyvinylpyrrolidone with 60% ethanol in an appropriate amount ;

[0044] Step S2: Granulating, granulating the above-mentioned soft material with a 40-mesh sieve, and s...

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Abstract

The invention discloses a preparation method of Gansu dispersible tablets, which includes mixing, making soft materials, granulating, drying, granulating, sieving, mixing, tableting, inner packaging, outer packaging and finished products. The steps of the specific preparation method of the dispersible tablet are as follows: step S1: mixing the soft material, taking the extract powder extracted from the root vegetable and adding it into the mixing drum, adding a certain amount of filler into the mixing drum, and mixing for 3 minutes by the agitator , take a certain amount of talcum powder and add it to the mixing drum, mix it through the mixer for 3 minutes, take a certain amount of primary disintegrant and add it to the mixing drum, mix it through the mixer for 3 minutes, take a certain amount of binder and add it to the mixing drum, Mix by mixer for 3 minutes to make a suitable soft material. The invention solves the problems of long disintegration time, poor dispersion uniformity and insufficient material mixing of the dispersible tablets produced by the traditional Gansu dispersible tablet preparation method by setting the primary disintegrating agent, secondary disintegrating agent, lubricant and talc powder Even problem.

Description

technical field [0001] The invention relates to the technical field of dispersible tablets, in particular to a preparation method of Gansu dispersible tablets. Background technique [0002] Dispersible tablet, also known as water dispersible tablet, refers to a tablet that disintegrates rapidly when exposed to water to form a uniform and viscous suspension solution. It has the characteristics of short time, rapid drug dissolution, fast absorption, high bioavailability, less adverse reactions, and convenient administration. Gansu Dispersible Tablets, the name of a Chinese patent medicine, has the effect of clearing away dampness and heat. Gansu Dispersible Tablets are brown oval tablets. Specific gas, bitter, astringent, used for acute viral hepatitis and chronic active hepatitis who belong to damp-heat syndrome, the dispersible tablets produced by the existing preparation method of Gansu dispersible tablets have long disintegration time, poor dispersion uniformity, and The ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/185A61P1/16A61P31/14A61P31/20A61K9/20A61K47/38A61K47/36A61K47/32A61K47/26A61K33/12
Inventor 欧阳淦杰周利琴赵明顺杨洪芳蒋彪赵庆梅龚凡
Owner YUNNAN JINWUHEI PHARMA
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