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Chinese herbal compound particle for treating radiation-induced lung injury and preparation method thereof

A technology of radiation-induced lung injury and traditional Chinese medicine, applied in the direction of medical formula, medical preparations containing active ingredients, drug combinations, etc., can solve the problems of drug-resistant bacterial infection, endocrine disorder, flora disorder, etc., and achieve the effect of convenient administration

Pending Publication Date: 2019-06-18
成都市第三人民医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, Western medicine has no effective treatment means and methods for radiation-induced pulmonary fibrosis. In the treatment of early lung injury, Western medicine is mostly limited to the use of large doses of antibiotics and hormones, which are prone to drug-resistant bacterial infections, flora disorder, abnormal immune function, Endocrine disorders and other side effects reduce the long-term quality of life of patients

Method used

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  • Chinese herbal compound particle for treating radiation-induced lung injury and preparation method thereof
  • Chinese herbal compound particle for treating radiation-induced lung injury and preparation method thereof
  • Chinese herbal compound particle for treating radiation-induced lung injury and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] The traditional Chinese medicine compound prescription for treating radiation-induced lung injury, which includes: 5 parts of mulberry leaves, 5 parts of almonds, 3 parts of honeysuckle, 3 parts of forsythia, 3 parts of bamboo leaves, 4 parts of coptis, 5 parts of Scrophulariaceae, 8 parts of buffalo horn, Beisha 5 parts of ginseng, 5 parts of Ophiopogon japonicus, 5 parts of Codonopsis pilosula, 5 parts of raw land, 4 parts of Morus alba, 5 parts of angelica, 4 parts of salvia miltiorrhiza, and 3 parts of licorice.

[0057] Each component of the Chinese medicine compound was soaked in 12 times the amount of water for 2 hours, decocted for 1.5 hours, added 10 times the amount of water again and decocted for 1.5 hours, filtered, combined the filtrates, and concentrated to a relative density of 1.15g / ml (measured at 60°C). ), add ethanol to make the alcohol content reach 50%, leave standstill for 24 hours, filter, and the filtrate reclaims ethanol under reduced pressure to...

Embodiment 2

[0059] A traditional Chinese medicine compound for treating radiation-induced lung injury, which includes:

[0060] 8 parts of mulberry leaves, 8 parts of almonds, 5 parts of honeysuckle, 5 parts of forsythia, 5 parts of bamboo leaves, 7 parts of coptis, 8 parts of Scrophulariaceae, 10 parts of buffalo horns, 8 parts of northern sand ginseng, 8 parts of Ophiopogon japonicus, 8 parts of Codonopsis ginseng 8 parts, 8 parts of raw land, 7 parts of Morus alba, 8 parts of angelica, 7 parts of salvia miltiorrhiza, and 5 parts of licorice.

[0061] Each component of the Chinese medicine compound was soaked in 12 times the amount of water for 2 hours, decocted for 1.5 hours, added 10 times the amount of water again and decocted for 1.5 hours, filtered, combined the filtrates, and concentrated to a relative density of 1.25g / ml (measured at 60°C). ), add ethanol to make the alcohol content reach 50%, leave standstill for 24 hours, filter, and the filtrate reclaims ethanol under reduced ...

Embodiment 3

[0063] A traditional Chinese medicine compound for treating radiation-induced lung injury, which includes:

[0064] 7 parts of mulberry leaves, 7 parts of almonds, 4 parts of honeysuckle, 4 parts of forsythia, 4 parts of bamboo leaves, 5 parts of Coptis chinensis, 7 parts of Scrophulariaceae, 9 parts of buffalo horns, 7 parts of northern sand ginseng, 7 parts of Ophiopogon japonicus, 7 parts of Codonopsis pilosula 7 parts, 7 parts of raw land, 6 parts of Morus alba, 7 parts of angelica, 6 parts of salvia miltiorrhiza, and 4 parts of licorice.

[0065] Each component of the Chinese medicine compound was soaked in 12 times the amount of water for 2 hours, decocted for 1.5 hours, added 10 times the amount of water again and decocted for 1.5 hours, filtered, combined the filtrates, and concentrated to a relative density of 1.20g / ml (measured at 60°C). ), add ethanol to make the alcohol content reach 50%, leave standstill for 24 hours, filter, and the filtrate reclaims ethanol unde...

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Abstract

The invention discloses a Chinese herbal compound particle for treating radiation-induced lung injury. The Chinese herbal compound particle is prepared from the raw materials in parts by weight: 'monarch' medicines, namely 5-8 parts of folium mori, and 5-8 parts of semen armeniacae amarae; 'minister' medicines, namely 3-5 parts of flos lonicerae, 3-5 parts of fructus forsythia, 3-5 parts of herbalophatheri, 4-7 parts of rhizoma coptidis, 8-10 parts of cornu bubali, 5-8 parts of radix dcrophulariae, 5-8 parts of dried radix rehmanniae, 5-8 parts of radix ophiopogonis, 5-8 parts of radix glehniae, and 5-8 parts of radix codonopsis; assistant medicines, namely 4-7 parts of radix salviae miltiorrhizae, 5-8 parts of radix angelicae sinensis, and 4-7 parts of cortex mori; and a guide medicine,namely 3-5 parts of radix glycyrrhizae. The Chinese herbal compound components are reasonable in compatibility, based on 'monarch', 'minister', assistant and guide principles, the multiple medicinal materials are mutually contained and coordinated, taking is convenient, and the Chinese herbal compound particle has a significant treating effect on treatment of radiation-induced lung injury.

Description

technical field [0001] The invention relates to a traditional Chinese medicine compound preparation. More specifically, the present invention relates to a traditional Chinese medicine compound granule for treating radiation-induced lung injury and a preparation method thereof. Background technique [0002] Radiation-induced lung injury (RILI) is a non-specific inflammation caused by damage to normal lung tissue in the radiation field area after radiation therapy for various thoracic tumors, such as lung cancer, esophageal cancer, breast cancer, and mediastinal tumors. reaction. It is divided into early acute radiation induced pneumonia (RIP) and late pulmonary fibrosis (idiopathic pulmonary fibrosis, IPF). Pulmonary fibrosis mostly occurs 6 months after the start of radiotherapy. At present, Western medicine has no effective treatment means and methods for radiation-induced pulmonary fibrosis. In the treatment of early lung injury, Western medicine is mostly limited to the...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61K9/16A61P11/00A61K35/32
Inventor 侯君郑德志呼永河由凤鸣肖雯婧
Owner 成都市第三人民医院
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